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Ability of Stratus OCT to identify localized retinal nerve fiber layer defects in patients with normal standard automated perimetry results.
Invest Ophthalmol Vis Sci 2007; 48(4):1635-41IO

Abstract

PURPOSE

To evaluate the ability of Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) with its internal normative database to discriminate between healthy eyes and eyes with a localized retinal nerve fiber layer (RNFL) defect not accompanied by a perimetric defect according to standard automated perimetry (SAP) (i.e., a preperimetric localized RNFL defect).

METHODS

Data were retrospectively reviewed from 49 eyes of 49 subjects with preperimetric localized RNFL defects, and 49 healthy control eyes of 49 age-matched subjects, with classification into each group based primarily on red-free fundus photography

RESULTS

The sensitivity and specificity of various OCT RNFL thickness parameters for identifying subjects with preperimetric localized RNFL defects was determined. In addition, the topographic relationship between the OCT-measured RNFL thickness and the localized RNFL defect location according to red-free fundus photography (i.e., the red-free RNFL defect) was examined. results. The sensitivity of the Stratus OCT RNFL thickness parameters ranged from 2.0% to 40.8%. The highest sensitivity was yielded using a criterion of > or =1 clock hour that were abnormal at the 5% level, which had a specificity of 85.7%. The OCT-measured RNFL thickness showed excellent topographic agreement with the red-free RNFL defect location.

CONCLUSIONS

Although the sensitivity of current Stratus OCT RNFL thickness parameters is low for preperimetric localized RNFL defects, it appears that OCT has the potential to recognize such defects. Further study is needed to develop new analytical methods that will increase OCT sensitivity for identifying preperimetric localized RNFL damage.

Authors+Show Affiliations

Department of Ophthalmology, Seoul National University College of Medicine, Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Gyunggi-do 463-707, Korea. twkim7@snu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17389494

Citation

Kim, Tae-Woo, et al. "Ability of Stratus OCT to Identify Localized Retinal Nerve Fiber Layer Defects in Patients With Normal Standard Automated Perimetry Results." Investigative Ophthalmology & Visual Science, vol. 48, no. 4, 2007, pp. 1635-41.
Kim TW, Park UC, Park KH, et al. Ability of Stratus OCT to identify localized retinal nerve fiber layer defects in patients with normal standard automated perimetry results. Invest Ophthalmol Vis Sci. 2007;48(4):1635-41.
Kim, T. W., Park, U. C., Park, K. H., & Kim, D. M. (2007). Ability of Stratus OCT to identify localized retinal nerve fiber layer defects in patients with normal standard automated perimetry results. Investigative Ophthalmology & Visual Science, 48(4), pp. 1635-41.
Kim TW, et al. Ability of Stratus OCT to Identify Localized Retinal Nerve Fiber Layer Defects in Patients With Normal Standard Automated Perimetry Results. Invest Ophthalmol Vis Sci. 2007;48(4):1635-41. PubMed PMID: 17389494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ability of Stratus OCT to identify localized retinal nerve fiber layer defects in patients with normal standard automated perimetry results. AU - Kim,Tae-Woo, AU - Park,Un-Chul, AU - Park,Ki Ho, AU - Kim,Dong Myung, PY - 2007/3/29/pubmed PY - 2007/5/15/medline PY - 2007/3/29/entrez SP - 1635 EP - 41 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 48 IS - 4 N2 - PURPOSE: To evaluate the ability of Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) with its internal normative database to discriminate between healthy eyes and eyes with a localized retinal nerve fiber layer (RNFL) defect not accompanied by a perimetric defect according to standard automated perimetry (SAP) (i.e., a preperimetric localized RNFL defect). METHODS: Data were retrospectively reviewed from 49 eyes of 49 subjects with preperimetric localized RNFL defects, and 49 healthy control eyes of 49 age-matched subjects, with classification into each group based primarily on red-free fundus photography RESULTS: The sensitivity and specificity of various OCT RNFL thickness parameters for identifying subjects with preperimetric localized RNFL defects was determined. In addition, the topographic relationship between the OCT-measured RNFL thickness and the localized RNFL defect location according to red-free fundus photography (i.e., the red-free RNFL defect) was examined. results. The sensitivity of the Stratus OCT RNFL thickness parameters ranged from 2.0% to 40.8%. The highest sensitivity was yielded using a criterion of > or =1 clock hour that were abnormal at the 5% level, which had a specificity of 85.7%. The OCT-measured RNFL thickness showed excellent topographic agreement with the red-free RNFL defect location. CONCLUSIONS: Although the sensitivity of current Stratus OCT RNFL thickness parameters is low for preperimetric localized RNFL defects, it appears that OCT has the potential to recognize such defects. Further study is needed to develop new analytical methods that will increase OCT sensitivity for identifying preperimetric localized RNFL damage. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/17389494/Ability_of_Stratus_OCT_to_identify_localized_retinal_nerve_fiber_layer_defects_in_patients_with_normal_standard_automated_perimetry_results_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.06-0800 DB - PRIME DP - Unbound Medicine ER -