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Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese.
Carcinogenesis. 2007 Sep; 28(9):2036-40.C

Abstract

BACKGROUNDS AND AIMS

The renin-angiotensin (RA) system including angiotensinogen (AGT), angiotensin I and angiotensin II influences the regulation of cell proliferation, angiogenesis and inflammation. AGT-20 A/C polymorphism is associated with the plasma AGT and angiotensin II levels. The aim of this study was to clarify the association of AGT-20 A/C polymorphism with susceptibility to gastric cancer and peptic ulcer in Japanese.

METHODS

We assessed the AGT-20 A/C polymorphism in Helicobacter pylori-positive patients with gastric cancer (n = 135), gastric ulcer (n = 148) and duodenal ulcer (n = 113) and controls (n = 292) consisting of H.pylori-positive gastritis alone (n = 160) and H.pylori-negative subjects (n = 132).

RESULTS

The age- and sex-adjusted odds ratios (ORs) of AGT-20 A/C and C/C genotypes relative to A/A genotype for gastric cancer risk were 1.695 [95% confidence interval (CI): 1.035-2.777] and 2.259 (95% CI: 0.351-14.533), respectively. The AGT-20 C allele increased the gastric cancer risk (OR: 1.685, 95% CI: 1.037-2.736), especially the intestinal type of gastric cancer (OR: 1.792, 95% CI: 1.040-3.089). However, there was no association between the AGT-20 polymorphism and susceptibility to peptic ulcer.

CONCLUSIONS

The carriage of AGT-20 C allele was associated with an increased risk for H.pylori-related gastric cancer development in Japanese, indicating that the RA system plays an important role in the pathogenesis of gastric cancer.

Authors+Show Affiliations

First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan. mitsu@hama-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17389608

Citation

Sugimoto, Mitsushige, et al. "Role of Angiotensinogen Gene Polymorphism On Helicobacter Pylori Infection-related Gastric Cancer Risk in Japanese." Carcinogenesis, vol. 28, no. 9, 2007, pp. 2036-40.
Sugimoto M, Furuta T, Shirai N, et al. Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese. Carcinogenesis. 2007;28(9):2036-40.
Sugimoto, M., Furuta, T., Shirai, N., Kodaira, C., Nishino, M., Ikuma, M., Sugimura, H., & Hishida, A. (2007). Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese. Carcinogenesis, 28(9), 2036-40.
Sugimoto M, et al. Role of Angiotensinogen Gene Polymorphism On Helicobacter Pylori Infection-related Gastric Cancer Risk in Japanese. Carcinogenesis. 2007;28(9):2036-40. PubMed PMID: 17389608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese. AU - Sugimoto,Mitsushige, AU - Furuta,Takahisa, AU - Shirai,Naohito, AU - Kodaira,Chise, AU - Nishino,Masafumi, AU - Ikuma,Mutsuhiro, AU - Sugimura,Haruhiko, AU - Hishida,Akira, Y1 - 2007/03/26/ PY - 2007/3/29/pubmed PY - 2008/3/15/medline PY - 2007/3/29/entrez SP - 2036 EP - 40 JF - Carcinogenesis JO - Carcinogenesis VL - 28 IS - 9 N2 - BACKGROUNDS AND AIMS: The renin-angiotensin (RA) system including angiotensinogen (AGT), angiotensin I and angiotensin II influences the regulation of cell proliferation, angiogenesis and inflammation. AGT-20 A/C polymorphism is associated with the plasma AGT and angiotensin II levels. The aim of this study was to clarify the association of AGT-20 A/C polymorphism with susceptibility to gastric cancer and peptic ulcer in Japanese. METHODS: We assessed the AGT-20 A/C polymorphism in Helicobacter pylori-positive patients with gastric cancer (n = 135), gastric ulcer (n = 148) and duodenal ulcer (n = 113) and controls (n = 292) consisting of H.pylori-positive gastritis alone (n = 160) and H.pylori-negative subjects (n = 132). RESULTS: The age- and sex-adjusted odds ratios (ORs) of AGT-20 A/C and C/C genotypes relative to A/A genotype for gastric cancer risk were 1.695 [95% confidence interval (CI): 1.035-2.777] and 2.259 (95% CI: 0.351-14.533), respectively. The AGT-20 C allele increased the gastric cancer risk (OR: 1.685, 95% CI: 1.037-2.736), especially the intestinal type of gastric cancer (OR: 1.792, 95% CI: 1.040-3.089). However, there was no association between the AGT-20 polymorphism and susceptibility to peptic ulcer. CONCLUSIONS: The carriage of AGT-20 C allele was associated with an increased risk for H.pylori-related gastric cancer development in Japanese, indicating that the RA system plays an important role in the pathogenesis of gastric cancer. SN - 0143-3334 UR - https://www.unboundmedicine.com/medline/citation/17389608/Role_of_angiotensinogen_gene_polymorphism_on_Helicobacter_pylori_infection_related_gastric_cancer_risk_in_Japanese_ L2 - https://academic.oup.com/carcin/article-lookup/doi/10.1093/carcin/bgm074 DB - PRIME DP - Unbound Medicine ER -