Tags

Type your tag names separated by a space and hit enter

Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats.
J Ethnopharmacol. 2007 May 30; 112(1):145-51.JE

Abstract

The hepatoprotective effect of ethanolic extract and its four different fractions (CHCl(3), EtOAc, n-BuOH, and remaining water fraction) of Vitis vinifera L. leaves was investigated against carbon tetrachloride (CCl(4))-induced acute hepatotoxicity in rats. The ethanolic extract was found active at 125mg/kg dose (per os). The ethanolic extract was fractionated through successive solvent-solvent extractions and the n-BuOH fraction in 83mg/kg dose possessed remarkable antioxidant and hepatoprotective activities. Liver damage was assessed by using biochemical parameters (plasma and liver tissue MDA [malondialdehyde], transaminase enzyme levels in plasma [AST-aspartate transaminase, ALT-alanine transferase] and liver GSH [glutathione] levels). Additionally, the pathological changes in liver were evaluated by histopathological studies. Legalon 70 Protect was used as standard natural originated drug.

Authors+Show Affiliations

Orhan DD
Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Hipodrom 06330, Ankara, Turkey. didem@gazi.edu.tr
Orhan N
No affiliation info available
Ergun E
No affiliation info available
Ergun F
No affiliation info available

MeSH

AnimalsAntioxidantsCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryFlavonoidsLipid PeroxidationLiver Function TestsMalePhenolsPhytotherapyPlant ExtractsPlant LeavesRatsRats, WistarVitis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17391882

Citation

Orhan, Didem Deliorman, et al. "Hepatoprotective Effect of Vitis Vinifera L. Leaves On Carbon Tetrachloride-induced Acute Liver Damage in Rats." Journal of Ethnopharmacology, vol. 112, no. 1, 2007, pp. 145-51.
Orhan DD, Orhan N, Ergun E, et al. Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats. J Ethnopharmacol. 2007;112(1):145-51.
Orhan, D. D., Orhan, N., Ergun, E., & Ergun, F. (2007). Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats. Journal of Ethnopharmacology, 112(1), 145-51.
Orhan DD, et al. Hepatoprotective Effect of Vitis Vinifera L. Leaves On Carbon Tetrachloride-induced Acute Liver Damage in Rats. J Ethnopharmacol. 2007 May 30;112(1):145-51. PubMed PMID: 17391882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats. AU - Orhan,Didem Deliorman, AU - Orhan,Nilüfer, AU - Ergun,Ender, AU - Ergun,Fatma, Y1 - 2007/02/20/ PY - 2006/08/14/received PY - 2007/02/09/revised PY - 2007/02/10/accepted PY - 2007/3/30/pubmed PY - 2007/9/15/medline PY - 2007/3/30/entrez SP - 145 EP - 51 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 112 IS - 1 N2 - The hepatoprotective effect of ethanolic extract and its four different fractions (CHCl(3), EtOAc, n-BuOH, and remaining water fraction) of Vitis vinifera L. leaves was investigated against carbon tetrachloride (CCl(4))-induced acute hepatotoxicity in rats. The ethanolic extract was found active at 125mg/kg dose (per os). The ethanolic extract was fractionated through successive solvent-solvent extractions and the n-BuOH fraction in 83mg/kg dose possessed remarkable antioxidant and hepatoprotective activities. Liver damage was assessed by using biochemical parameters (plasma and liver tissue MDA [malondialdehyde], transaminase enzyme levels in plasma [AST-aspartate transaminase, ALT-alanine transferase] and liver GSH [glutathione] levels). Additionally, the pathological changes in liver were evaluated by histopathological studies. Legalon 70 Protect was used as standard natural originated drug. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17391882/Hepatoprotective_effect_of_Vitis_vinifera_L__leaves_on_carbon_tetrachloride_induced_acute_liver_damage_in_rats_ DB - PRIME DP - Unbound Medicine ER -