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Omega 3 fatty acids and the brain: review of studies in depression.
Asia Pac J Clin Nutr. 2007; 16 Suppl 1:391-7.AP

Abstract

The brain is a lipid-rich organ containing mostly complex polar phospholipids, sphingolipids, gangliosides and cholesterol. These lipids are involved in the structure and function of cell membranes in the brain. The glycerophospholipids in the brain contain a high proportion of polyunsaturated fatty acids (PUFA) derived from the essential fatty acids, linoleic acid and alpha-linolenic acid. The main PUFA in the brain are docosahexaenoic acid (DHA, all cis 4,7,10,13,16,19-22:6) derived from the omega 3 fatty acid, alpha-linolenic acid, and arachidonic acid (AA, all cis 5,8,11,14-20:4) and docosatetraenoic acid (all cis 7,10,13,16-22:4), both derived from the omega 6 fatty acid, linoleic acid. Experimental studies in animals have shown that diets lacking omega 3 PUFA lead to substantial disturbances in neural function, which in most circumstances can be restored by the inclusion of omega 3 PUFA in the diet. In the past 10 years there has been an emerging interest in treating neuropsychological disorders (depression and schizophrenia) with omega 3 PUFA. This paper discusses the clinical studies conducted in the area of depression and omega 3 PUFA and the possible mechanisms of action of these PUFA. It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties.

Authors+Show Affiliations

School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia. andrew.sinclair@deakin.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17392137

Citation

Sinclair, Andrew J., et al. "Omega 3 Fatty Acids and the Brain: Review of Studies in Depression." Asia Pacific Journal of Clinical Nutrition, vol. 16 Suppl 1, 2007, pp. 391-7.
Sinclair AJ, Begg D, Mathai M, et al. Omega 3 fatty acids and the brain: review of studies in depression. Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7.
Sinclair, A. J., Begg, D., Mathai, M., & Weisinger, R. S. (2007). Omega 3 fatty acids and the brain: review of studies in depression. Asia Pacific Journal of Clinical Nutrition, 16 Suppl 1, 391-7.
Sinclair AJ, et al. Omega 3 Fatty Acids and the Brain: Review of Studies in Depression. Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7. PubMed PMID: 17392137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega 3 fatty acids and the brain: review of studies in depression. AU - Sinclair,Andrew J, AU - Begg,Denovan, AU - Mathai,Michael, AU - Weisinger,Richard S, PY - 2007/3/30/pubmed PY - 2007/6/15/medline PY - 2007/3/30/entrez SP - 391 EP - 7 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 16 Suppl 1 N2 - The brain is a lipid-rich organ containing mostly complex polar phospholipids, sphingolipids, gangliosides and cholesterol. These lipids are involved in the structure and function of cell membranes in the brain. The glycerophospholipids in the brain contain a high proportion of polyunsaturated fatty acids (PUFA) derived from the essential fatty acids, linoleic acid and alpha-linolenic acid. The main PUFA in the brain are docosahexaenoic acid (DHA, all cis 4,7,10,13,16,19-22:6) derived from the omega 3 fatty acid, alpha-linolenic acid, and arachidonic acid (AA, all cis 5,8,11,14-20:4) and docosatetraenoic acid (all cis 7,10,13,16-22:4), both derived from the omega 6 fatty acid, linoleic acid. Experimental studies in animals have shown that diets lacking omega 3 PUFA lead to substantial disturbances in neural function, which in most circumstances can be restored by the inclusion of omega 3 PUFA in the diet. In the past 10 years there has been an emerging interest in treating neuropsychological disorders (depression and schizophrenia) with omega 3 PUFA. This paper discusses the clinical studies conducted in the area of depression and omega 3 PUFA and the possible mechanisms of action of these PUFA. It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/17392137/Omega_3_fatty_acids_and_the_brain:_review_of_studies_in_depression_ L2 - http://apjcn.nhri.org.tw/server/APJCN/16 Suppl 1//391.pdf DB - PRIME DP - Unbound Medicine ER -