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Dietary carotenoids and risk of breast cancer in Chinese women.
Asia Pac J Clin Nutr 2007; 16 Suppl 1:437-42AP

Abstract

There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, the protective effect of carotenoids on breast cancer has been inconclusive. To investigate whether intake of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin is inversely associated with breast cancer risk, a case-control study was conducted in China during 2004-2005. The cases were 122 female patients aged 24-87 years with histopathologically confirmed breast cancer. 632 healthy women age-matched were randomly recruited from outpatient clinics. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable food frequency questionnaire. The USDA nutrient composition database was used to calculate intake of the specific carotenoids. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), accounting for age, locality, education, body mass index, smoking, passive smoking, physical activity, number of children breastfed, menopausal status, oral contraceptive use, biopsy-confirmed benign breast diseases, family history of breast cancer, and total energy intake. Compared with the highest versus lowest quartile of intake, the adjusted ORs were 0.26 (95% CI 0.14-0.46) for lycopene, 0.38 (95% CI 0.21-0.71) for beta-carotene, 0.43 (95% CI 0.23-0.82) for beta-cryptoxanthin, and 0.37 (95% CI 0.20-0.68) for total carotenoids, with statistically significant tests for trend. There was no association with breast cancer for alpha-carotene and lutein/zeaxanthin. It is concluded that higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women. More research to examine the relationship between carotenoids and breast cancer risk is warranted.

Authors+Show Affiliations

Women's Hospital, School of Medicine, Zhejiang University, P.R. China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17392146

Citation

Huang, Jiang-ping, et al. "Dietary Carotenoids and Risk of Breast Cancer in Chinese Women." Asia Pacific Journal of Clinical Nutrition, vol. 16 Suppl 1, 2007, pp. 437-42.
Huang JP, Zhang M, Holman CD, et al. Dietary carotenoids and risk of breast cancer in Chinese women. Asia Pac J Clin Nutr. 2007;16 Suppl 1:437-42.
Huang, J. P., Zhang, M., Holman, C. D., & Xie, X. (2007). Dietary carotenoids and risk of breast cancer in Chinese women. Asia Pacific Journal of Clinical Nutrition, 16 Suppl 1, pp. 437-42.
Huang JP, et al. Dietary Carotenoids and Risk of Breast Cancer in Chinese Women. Asia Pac J Clin Nutr. 2007;16 Suppl 1:437-42. PubMed PMID: 17392146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary carotenoids and risk of breast cancer in Chinese women. AU - Huang,Jiang-ping, AU - Zhang,Min, AU - Holman,C D'Arcy J, AU - Xie,Xing, PY - 2007/3/30/pubmed PY - 2007/6/15/medline PY - 2007/3/30/entrez SP - 437 EP - 42 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 16 Suppl 1 N2 - There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, the protective effect of carotenoids on breast cancer has been inconclusive. To investigate whether intake of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin is inversely associated with breast cancer risk, a case-control study was conducted in China during 2004-2005. The cases were 122 female patients aged 24-87 years with histopathologically confirmed breast cancer. 632 healthy women age-matched were randomly recruited from outpatient clinics. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable food frequency questionnaire. The USDA nutrient composition database was used to calculate intake of the specific carotenoids. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), accounting for age, locality, education, body mass index, smoking, passive smoking, physical activity, number of children breastfed, menopausal status, oral contraceptive use, biopsy-confirmed benign breast diseases, family history of breast cancer, and total energy intake. Compared with the highest versus lowest quartile of intake, the adjusted ORs were 0.26 (95% CI 0.14-0.46) for lycopene, 0.38 (95% CI 0.21-0.71) for beta-carotene, 0.43 (95% CI 0.23-0.82) for beta-cryptoxanthin, and 0.37 (95% CI 0.20-0.68) for total carotenoids, with statistically significant tests for trend. There was no association with breast cancer for alpha-carotene and lutein/zeaxanthin. It is concluded that higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women. More research to examine the relationship between carotenoids and breast cancer risk is warranted. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/17392146/Dietary_carotenoids_and_risk_of_breast_cancer_in_Chinese_women_ L2 - http://apjcn.nhri.org.tw/server/APJCN/16 Suppl 1//437.pdf DB - PRIME DP - Unbound Medicine ER -