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Discrete place fields of hippocampal formation interneurons.
J Neurophysiol. 2007 Jun; 97(6):4152-61.JN

Abstract

The spike discharge of hippocampal excitatory principal cells, also called "place cells," is highly location specific, but the discharge of local inhibitory interneurons is thought to display relatively low spatial specificity. Whereas in other brain regions, such as sensory neocortex, the activity of interneurons is often exquisitely stimulus selective and directly determines the responses of neighboring excitatory neurons, the activity of hippocampal interneurons typically lacks the requisite specificity needed to shape the defined structure of principal cell fields. Here we show that hippocampal formation interneurons have "on" fields (abrupt increases in activity) and "off" fields (abrupt decreases in activity) that are associated with the same location-specific informational content, spatial resolution, and dependency on context as the "place fields" of CA1 principal cells. This establishes that interneurons have well-defined place fields, thus having important implications for understanding how the hippocampus represents spatial information.

Authors+Show Affiliations

The Neurosciences Institute, 10640 John J. Hopkins Drive, San Diego, CA 92121-1120, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17392415

Citation

Wilent, W Bryan, and Douglas A. Nitz. "Discrete Place Fields of Hippocampal Formation Interneurons." Journal of Neurophysiology, vol. 97, no. 6, 2007, pp. 4152-61.
Wilent WB, Nitz DA. Discrete place fields of hippocampal formation interneurons. J Neurophysiol. 2007;97(6):4152-61.
Wilent, W. B., & Nitz, D. A. (2007). Discrete place fields of hippocampal formation interneurons. Journal of Neurophysiology, 97(6), 4152-61.
Wilent WB, Nitz DA. Discrete Place Fields of Hippocampal Formation Interneurons. J Neurophysiol. 2007;97(6):4152-61. PubMed PMID: 17392415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discrete place fields of hippocampal formation interneurons. AU - Wilent,W Bryan, AU - Nitz,Douglas A, Y1 - 2007/03/28/ PY - 2007/3/30/pubmed PY - 2007/8/19/medline PY - 2007/3/30/entrez SP - 4152 EP - 61 JF - Journal of neurophysiology JO - J Neurophysiol VL - 97 IS - 6 N2 - The spike discharge of hippocampal excitatory principal cells, also called "place cells," is highly location specific, but the discharge of local inhibitory interneurons is thought to display relatively low spatial specificity. Whereas in other brain regions, such as sensory neocortex, the activity of interneurons is often exquisitely stimulus selective and directly determines the responses of neighboring excitatory neurons, the activity of hippocampal interneurons typically lacks the requisite specificity needed to shape the defined structure of principal cell fields. Here we show that hippocampal formation interneurons have "on" fields (abrupt increases in activity) and "off" fields (abrupt decreases in activity) that are associated with the same location-specific informational content, spatial resolution, and dependency on context as the "place fields" of CA1 principal cells. This establishes that interneurons have well-defined place fields, thus having important implications for understanding how the hippocampus represents spatial information. SN - 0022-3077 UR - https://www.unboundmedicine.com/medline/citation/17392415/Discrete_place_fields_of_hippocampal_formation_interneurons_ L2 - https://journals.physiology.org/doi/10.1152/jn.01200.2006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -