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Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
Diabetes Care. 2007 Apr; 30(4):854-60.DC

Abstract

OBJECTIVE

Although sex differences have been reported for associations between obesity and inflammation, the question of whether there is an effect modification by sex in the association between inflammation and type 2 diabetes has not been investigated in detail. Therefore, the aim of this study was to compare associations of markers of inflammation with type 2 diabetes risk between men and women.

RESEARCH DESIGN AND METHODS

Following a case-cohort design, cases of incident type 2 diabetes were identified from 7,936 subjects aged 35-74 years at baseline who participated in the population-based Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Research in the Region of Augsburg (KORA) studies conducted between 1984 and 2002. Concentrations of C-reactive protein (CRP) and interleukin (IL)-6 were measured in 527 cases of incident type 2 diabetes (305 men and 222 women) and 1,698 noncases (889 men and 809 women).

RESULTS

After adjustment for age and survey and lifestyle factors including smoking, alcohol intake, and physical activity, elevated concentrations of CRP showed a considerably stronger association with risk of type 2 diabetes in women (hazard ratio comparing tertile extremes 7.60 [95% CI 4.43-13.04]) than in men (1.84 [1.27-2.67]). The P value for the sex interaction was <0.001. Further adjustment for metabolic risk factors considerably attenuated these associations, and they became nonsignificant in men but remained significant in women. IL-6 was also more strongly associated with type 2 diabetes in women, but there was no significant sex interaction.

CONCLUSIONS

Our data suggest that inflammatory processes may be of particular importance in the pathogenesis of type 2 diabetes in women.

Authors+Show Affiliations

Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17392546

Citation

Thorand, Barbara, et al. "Sex Differences in the Prediction of Type 2 Diabetes By Inflammatory Markers: Results From the MONICA/KORA Augsburg Case-cohort Study, 1984-2002." Diabetes Care, vol. 30, no. 4, 2007, pp. 854-60.
Thorand B, Baumert J, Kolb H, et al. Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Diabetes Care. 2007;30(4):854-60.
Thorand, B., Baumert, J., Kolb, H., Meisinger, C., Chambless, L., Koenig, W., & Herder, C. (2007). Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Diabetes Care, 30(4), 854-60.
Thorand B, et al. Sex Differences in the Prediction of Type 2 Diabetes By Inflammatory Markers: Results From the MONICA/KORA Augsburg Case-cohort Study, 1984-2002. Diabetes Care. 2007;30(4):854-60. PubMed PMID: 17392546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. AU - Thorand,Barbara, AU - Baumert,Jens, AU - Kolb,Hubert, AU - Meisinger,Christa, AU - Chambless,Lloyd, AU - Koenig,Wolfgang, AU - Herder,Christian, PY - 2007/3/30/pubmed PY - 2007/6/15/medline PY - 2007/3/30/entrez SP - 854 EP - 60 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 4 N2 - OBJECTIVE: Although sex differences have been reported for associations between obesity and inflammation, the question of whether there is an effect modification by sex in the association between inflammation and type 2 diabetes has not been investigated in detail. Therefore, the aim of this study was to compare associations of markers of inflammation with type 2 diabetes risk between men and women. RESEARCH DESIGN AND METHODS: Following a case-cohort design, cases of incident type 2 diabetes were identified from 7,936 subjects aged 35-74 years at baseline who participated in the population-based Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Research in the Region of Augsburg (KORA) studies conducted between 1984 and 2002. Concentrations of C-reactive protein (CRP) and interleukin (IL)-6 were measured in 527 cases of incident type 2 diabetes (305 men and 222 women) and 1,698 noncases (889 men and 809 women). RESULTS: After adjustment for age and survey and lifestyle factors including smoking, alcohol intake, and physical activity, elevated concentrations of CRP showed a considerably stronger association with risk of type 2 diabetes in women (hazard ratio comparing tertile extremes 7.60 [95% CI 4.43-13.04]) than in men (1.84 [1.27-2.67]). The P value for the sex interaction was <0.001. Further adjustment for metabolic risk factors considerably attenuated these associations, and they became nonsignificant in men but remained significant in women. IL-6 was also more strongly associated with type 2 diabetes in women, but there was no significant sex interaction. CONCLUSIONS: Our data suggest that inflammatory processes may be of particular importance in the pathogenesis of type 2 diabetes in women. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17392546/Sex_differences_in_the_prediction_of_type_2_diabetes_by_inflammatory_markers:_results_from_the_MONICA/KORA_Augsburg_case_cohort_study_1984_2002_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=17392546 DB - PRIME DP - Unbound Medicine ER -