Tags

Type your tag names separated by a space and hit enter

Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy.
Med Sci Monit. 2007 Apr; 13(4):CR191-4.MS

Abstract

BACKGROUND

Magnesium sulfate is used for seizure therapy and prophylaxis in women with eclampsia and preeclampsia worldwide. Magnesium may act by opposing calcium-dependent arterial constriction and may also antagonize the increase in intracellular calcium concentration. The objectives were to study the alterations in serum ionized magnesium and calcium and their relationship in patients with severe pre-eclampsia/eclampsia receiving magnesium sulfate therapy.

MATERIAL/METHODS

Fifty patients in singleton pregnancy with severe pre-eclampsia or eclampsia who were candidates for intravenous magnesium sulfate infusion were studied. Serum ionized magnesium and calcium concentration were determined in blood samples taken before magnesium sulfate infusion, 30 and 240 minutes after the initiation of the infusion, and 4 hours after discontinuation of the therapy. Repeated-measure ANOVA, paired t-test, and Pearson's correlation coefficient were used to analyze the data.

RESULTS

Mean baseline levels of ionized magnesium and ionized calcium were 1.3+/-0.5 mEq/l and 3.8+/-0.5 mg/dl, respectively. The mean concentration of ionized magnesium changed significantly at the stated intervals, while mean ionized calcium values did not. Significant correlation was found between ionized calcium and magnesium four hours after the initiation of magnesium sulfate infusion and after discontinuation of the therapy.

CONCLUSIONS

Magnesium ion does not appear to exert its therapeutic effect in pre-eclampsia/eclampsia by substantially modulating serum ionized calcium. However, the effect of exogenous Mg on intracellular calcium cannot be ruled out.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Kerman University of Medical Sciences, Kerman, Iran. shahnaz_aali@excite.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17392650

Citation

Aali, Shahnaz, et al. "Serum Magnesium and Calcium Ions in Patients With Severe Pre-eclampsia/eclampsia Undergoing Magnesium Sulfate Therapy." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 13, no. 4, 2007, pp. CR191-4.
Aali S, Khazaeli P, Ghasemi F, et al. Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy. Med Sci Monit. 2007;13(4):CR191-4.
Aali, S., Khazaeli, P., Ghasemi, F., & Mehdizadeh, A. (2007). Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 13(4), CR191-4.
Aali S, et al. Serum Magnesium and Calcium Ions in Patients With Severe Pre-eclampsia/eclampsia Undergoing Magnesium Sulfate Therapy. Med Sci Monit. 2007;13(4):CR191-4. PubMed PMID: 17392650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy. AU - Aali,Shahnaz, AU - Khazaeli,Payam, AU - Ghasemi,Fatemeh, AU - Mehdizadeh,Anahita, PY - 2006/05/04/received PY - 2006/10/12/accepted PY - 2007/3/30/pubmed PY - 2008/3/7/medline PY - 2007/3/30/entrez SP - CR191 EP - 4 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 13 IS - 4 N2 - BACKGROUND: Magnesium sulfate is used for seizure therapy and prophylaxis in women with eclampsia and preeclampsia worldwide. Magnesium may act by opposing calcium-dependent arterial constriction and may also antagonize the increase in intracellular calcium concentration. The objectives were to study the alterations in serum ionized magnesium and calcium and their relationship in patients with severe pre-eclampsia/eclampsia receiving magnesium sulfate therapy. MATERIAL/METHODS: Fifty patients in singleton pregnancy with severe pre-eclampsia or eclampsia who were candidates for intravenous magnesium sulfate infusion were studied. Serum ionized magnesium and calcium concentration were determined in blood samples taken before magnesium sulfate infusion, 30 and 240 minutes after the initiation of the infusion, and 4 hours after discontinuation of the therapy. Repeated-measure ANOVA, paired t-test, and Pearson's correlation coefficient were used to analyze the data. RESULTS: Mean baseline levels of ionized magnesium and ionized calcium were 1.3+/-0.5 mEq/l and 3.8+/-0.5 mg/dl, respectively. The mean concentration of ionized magnesium changed significantly at the stated intervals, while mean ionized calcium values did not. Significant correlation was found between ionized calcium and magnesium four hours after the initiation of magnesium sulfate infusion and after discontinuation of the therapy. CONCLUSIONS: Magnesium ion does not appear to exert its therapeutic effect in pre-eclampsia/eclampsia by substantially modulating serum ionized calcium. However, the effect of exogenous Mg on intracellular calcium cannot be ruled out. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/17392650/Serum_magnesium_and_calcium_ions_in_patients_with_severe_pre_eclampsia/eclampsia_undergoing_magnesium_sulfate_therapy_ L2 - https://www.medscimonit.com/download/index/idArt/481104 DB - PRIME DP - Unbound Medicine ER -