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Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials.
Eur J Clin Nutr. 2008 Feb; 62(2):155-61.EJ

Abstract

OBJECTIVE

To clarify the effects of isoflavone intake on bone resorption and bone formation.

METHODS

We identified randomized controlled trials related to urinary deoxypyridinoline (Dpyr, a bone resorption marker) and serum bone-specific alkaline phosphatase (BAP, a bone formation marker) listed on MEDLINE (January 1966-April 2006), the Cochrane Controlled Trials Register, EMBASE (1985-January 2006), Science Citation Index and PUBMED (updated till April 2006).

RESULTS

Nine studies with a total of 432 subjects were selected for meta-analysis. The urinary Dpyr concentration in subjects who consumed isoflavones decreased significantly by -2.08 nmol/mmol (95% confidence interval (CI): -3.82 to -0.34 nmol/mmol) in comparison with that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake significantly increased serum BAP by 1.48 microg/l (95% CI: 0.22-2.75 mug/l). Decreases in the urinary Dpyr concentration with isoflavone intake of <90 mg/day and with treatment lasting less than 12 weeks were -2.34 nmol/mmol (95% CI: -4.46 to -0.22 nmol/mmol) and -2.03 nmol/mmol (95% CI: -3.20 to -0.85 nmol/mmol), respectively.

CONCLUSIONS

Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation. These favorable effects occur even if <90 mg/day of isoflavones are consumed or the intervention lasts less than 12 weeks.

Authors+Show Affiliations

Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17392695

Citation

Ma, D-F, et al. "Soy Isoflavone Intake Inhibits Bone Resorption and Stimulates Bone Formation in Menopausal Women: Meta-analysis of Randomized Controlled Trials." European Journal of Clinical Nutrition, vol. 62, no. 2, 2008, pp. 155-61.
Ma DF, Qin LQ, Wang PY, et al. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2008;62(2):155-61.
Ma, D. F., Qin, L. Q., Wang, P. Y., & Katoh, R. (2008). Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. European Journal of Clinical Nutrition, 62(2), 155-61.
Ma DF, et al. Soy Isoflavone Intake Inhibits Bone Resorption and Stimulates Bone Formation in Menopausal Women: Meta-analysis of Randomized Controlled Trials. Eur J Clin Nutr. 2008;62(2):155-61. PubMed PMID: 17392695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. AU - Ma,D-F, AU - Qin,L-Q, AU - Wang,P-Y, AU - Katoh,R, Y1 - 2007/03/28/ PY - 2007/3/30/pubmed PY - 2008/5/13/medline PY - 2007/3/30/entrez SP - 155 EP - 61 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 2 N2 - OBJECTIVE: To clarify the effects of isoflavone intake on bone resorption and bone formation. METHODS: We identified randomized controlled trials related to urinary deoxypyridinoline (Dpyr, a bone resorption marker) and serum bone-specific alkaline phosphatase (BAP, a bone formation marker) listed on MEDLINE (January 1966-April 2006), the Cochrane Controlled Trials Register, EMBASE (1985-January 2006), Science Citation Index and PUBMED (updated till April 2006). RESULTS: Nine studies with a total of 432 subjects were selected for meta-analysis. The urinary Dpyr concentration in subjects who consumed isoflavones decreased significantly by -2.08 nmol/mmol (95% confidence interval (CI): -3.82 to -0.34 nmol/mmol) in comparison with that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake significantly increased serum BAP by 1.48 microg/l (95% CI: 0.22-2.75 mug/l). Decreases in the urinary Dpyr concentration with isoflavone intake of <90 mg/day and with treatment lasting less than 12 weeks were -2.34 nmol/mmol (95% CI: -4.46 to -0.22 nmol/mmol) and -2.03 nmol/mmol (95% CI: -3.20 to -0.85 nmol/mmol), respectively. CONCLUSIONS: Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation. These favorable effects occur even if <90 mg/day of isoflavones are consumed or the intervention lasts less than 12 weeks. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17392695/Soy_isoflavone_intake_inhibits_bone_resorption_and_stimulates_bone_formation_in_menopausal_women:_meta_analysis_of_randomized_controlled_trials_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602748 DB - PRIME DP - Unbound Medicine ER -