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Necrobiotic xanthogranuloma.
Arch Dermatol. 1992 Jan; 128(1):94-100.AD

Abstract

We reviewed 32 cases of necrobiotic xanthogranuloma and 16 cases from the world literature. Necrobiotic xanthogranuloma is a destructive dermal and subcutaneous xanthogranuloma that most frequently involves the face (periorbital region) and trunk. Monoclonal gammopathy is common (IgG-kappa in 23 cases and IgG-lambda in nine cases), and cryoglobulins have also been found. Low complement levels, anemia, and leukopenia are frequently present. Bone marrow examination shows plasma cell proliferation and, rarely, true myeloma. We describe mucosal, muscle, and systemic lesions, including xanthogranulomatous myocardial lesions. The clinical course is chronic and often progressive. Low-dose chlorambucil treatment is safe and effective, but individual patients have responded to treatment with corticosteroids, melphalan, local radiation, and plasma exchange.

Authors+Show Affiliations

Department of Dermatology, Mayo Clinic, Rochester, Minn.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1739294

Citation

Mehregan, D A., and R K. Winkelmann. "Necrobiotic Xanthogranuloma." Archives of Dermatology, vol. 128, no. 1, 1992, pp. 94-100.
Mehregan DA, Winkelmann RK. Necrobiotic xanthogranuloma. Arch Dermatol. 1992;128(1):94-100.
Mehregan, D. A., & Winkelmann, R. K. (1992). Necrobiotic xanthogranuloma. Archives of Dermatology, 128(1), 94-100.
Mehregan DA, Winkelmann RK. Necrobiotic Xanthogranuloma. Arch Dermatol. 1992;128(1):94-100. PubMed PMID: 1739294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrobiotic xanthogranuloma. AU - Mehregan,D A, AU - Winkelmann,R K, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 94 EP - 100 JF - Archives of dermatology JO - Arch Dermatol VL - 128 IS - 1 N2 - We reviewed 32 cases of necrobiotic xanthogranuloma and 16 cases from the world literature. Necrobiotic xanthogranuloma is a destructive dermal and subcutaneous xanthogranuloma that most frequently involves the face (periorbital region) and trunk. Monoclonal gammopathy is common (IgG-kappa in 23 cases and IgG-lambda in nine cases), and cryoglobulins have also been found. Low complement levels, anemia, and leukopenia are frequently present. Bone marrow examination shows plasma cell proliferation and, rarely, true myeloma. We describe mucosal, muscle, and systemic lesions, including xanthogranulomatous myocardial lesions. The clinical course is chronic and often progressive. Low-dose chlorambucil treatment is safe and effective, but individual patients have responded to treatment with corticosteroids, melphalan, local radiation, and plasma exchange. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/1739294/Necrobiotic_xanthogranuloma_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/128/pg/94 DB - PRIME DP - Unbound Medicine ER -