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Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide.
J Neurosci Res 2007; 85(9):1834-50JN

Abstract

The neural membranes contain phospholipids, sphingolipids, cholesterol, and proteins. Glycerophospholipids and sphingolipids are precursors for lipid mediators involved in signal transduction processes. Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA). Arachidonic acid is metabolized to eicosanoids and DHA is metabolized to docosanoids. The catabolism of glycosphingolipids generates ceramide, ceramide 1-phosphate, sphingosine, and sphingosine 1-phosphate. These metabolites modulate PLA(2) activity. Arachidonic acid, a product derived from glycerophospholipid catabolism by PLA(2), modulates sphingomyelinase (SMase), the enzyme that generates ceramide and phosphocholine. Furthermore, sphingosine 1-phosphate modulates cyclooxygenase, an enzyme responsible for eicosanoid production in brain. This suggests that an interplay and cross talk occurs between lipid mediators of glycerophospholipid and glycosphingolipid metabolism in brain tissue. This interplay between metabolites of glycerophospholipid and sphingolipid metabolism may play an important role in initiation and maintenance of oxidative stress associated with neurologic disorders as well as in neural cell proliferation, differentiation, and apoptosis. Recent studies indicate that PLA(2) and SMase inhibitors can be used as neuroprotective and anti-apoptotic agents. Development of novel inhibitors of PLA(2) and SMase may be useful for the treatment of oxidative stress, and apoptosis associated with neurologic disorders such as stroke, Alzheimer disease, Parkinson disease, and head and spinal cord injuries.

Authors+Show Affiliations

Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio 43210, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17393491

Citation

Farooqui, Akhlaq A., et al. "Interactions Between Neural Membrane Glycerophospholipid and Sphingolipid Mediators: a Recipe for Neural Cell Survival or Suicide." Journal of Neuroscience Research, vol. 85, no. 9, 2007, pp. 1834-50.
Farooqui AA, Horrocks LA, Farooqui T. Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide. J Neurosci Res. 2007;85(9):1834-50.
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007). Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide. Journal of Neuroscience Research, 85(9), pp. 1834-50.
Farooqui AA, Horrocks LA, Farooqui T. Interactions Between Neural Membrane Glycerophospholipid and Sphingolipid Mediators: a Recipe for Neural Cell Survival or Suicide. J Neurosci Res. 2007;85(9):1834-50. PubMed PMID: 17393491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide. AU - Farooqui,Akhlaq A, AU - Horrocks,Lloyd A, AU - Farooqui,Tahira, PY - 2007/3/30/pubmed PY - 2007/9/22/medline PY - 2007/3/30/entrez SP - 1834 EP - 50 JF - Journal of neuroscience research JO - J. Neurosci. Res. VL - 85 IS - 9 N2 - The neural membranes contain phospholipids, sphingolipids, cholesterol, and proteins. Glycerophospholipids and sphingolipids are precursors for lipid mediators involved in signal transduction processes. Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA). Arachidonic acid is metabolized to eicosanoids and DHA is metabolized to docosanoids. The catabolism of glycosphingolipids generates ceramide, ceramide 1-phosphate, sphingosine, and sphingosine 1-phosphate. These metabolites modulate PLA(2) activity. Arachidonic acid, a product derived from glycerophospholipid catabolism by PLA(2), modulates sphingomyelinase (SMase), the enzyme that generates ceramide and phosphocholine. Furthermore, sphingosine 1-phosphate modulates cyclooxygenase, an enzyme responsible for eicosanoid production in brain. This suggests that an interplay and cross talk occurs between lipid mediators of glycerophospholipid and glycosphingolipid metabolism in brain tissue. This interplay between metabolites of glycerophospholipid and sphingolipid metabolism may play an important role in initiation and maintenance of oxidative stress associated with neurologic disorders as well as in neural cell proliferation, differentiation, and apoptosis. Recent studies indicate that PLA(2) and SMase inhibitors can be used as neuroprotective and anti-apoptotic agents. Development of novel inhibitors of PLA(2) and SMase may be useful for the treatment of oxidative stress, and apoptosis associated with neurologic disorders such as stroke, Alzheimer disease, Parkinson disease, and head and spinal cord injuries. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/17393491/Interactions_between_neural_membrane_glycerophospholipid_and_sphingolipid_mediators:_a_recipe_for_neural_cell_survival_or_suicide_ L2 - https://doi.org/10.1002/jnr.21268 DB - PRIME DP - Unbound Medicine ER -