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Effect of memantine and CNQX in the acquisition, expression and reinstatement of cocaine-induced conditioned place preference.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 09; 31(4):932-9.PN

Abstract

The present study evaluates the effect of memantine, a non-competitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist and CNQX, an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist on the rewarding effects of cocaine in mice, using the conditioned place preference (CPP) paradigm. Cocaine-induced CPP was studied pairing this drug with different memantine or CNQX doses during either the acquisition or the expression phase of the procedure. Once CPP was established, and the preference extinguished, reinstatement was induced by a priming dose of cocaine. Both antagonists, which in themselves do not present motivational actions on the preference shown by the animals, abolished the acquisition and expression of the cocaine-induced CPP. Neither of the antagonists precipitated reinstatement of the preference induced by cocaine but memantine blocked the cocaine-primed reinstatement. Our results suggest that cocaine-induced CPP and reinstatement is largely dependent on glutamate neurotransmission, and confer a putative role for memantine among the tools useful for cocaine management and treatment.

Authors+Show Affiliations

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez 21, 46010 Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17395352

Citation

Maldonado, C, et al. "Effect of Memantine and CNQX in the Acquisition, Expression and Reinstatement of Cocaine-induced Conditioned Place Preference." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 31, no. 4, 2007, pp. 932-9.
Maldonado C, Rodríguez-Arias M, Castillo A, et al. Effect of memantine and CNQX in the acquisition, expression and reinstatement of cocaine-induced conditioned place preference. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(4):932-9.
Maldonado, C., Rodríguez-Arias, M., Castillo, A., Aguilar, M. A., & Miñarro, J. (2007). Effect of memantine and CNQX in the acquisition, expression and reinstatement of cocaine-induced conditioned place preference. Progress in Neuro-psychopharmacology & Biological Psychiatry, 31(4), 932-9.
Maldonado C, et al. Effect of Memantine and CNQX in the Acquisition, Expression and Reinstatement of Cocaine-induced Conditioned Place Preference. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):932-9. PubMed PMID: 17395352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of memantine and CNQX in the acquisition, expression and reinstatement of cocaine-induced conditioned place preference. AU - Maldonado,C, AU - Rodríguez-Arias,M, AU - Castillo,A, AU - Aguilar,M A, AU - Miñarro,J, Y1 - 2007/02/28/ PY - 2006/10/27/received PY - 2007/02/05/revised PY - 2007/02/22/accepted PY - 2007/3/31/pubmed PY - 2007/8/4/medline PY - 2007/3/31/entrez SP - 932 EP - 9 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 31 IS - 4 N2 - The present study evaluates the effect of memantine, a non-competitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist and CNQX, an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist on the rewarding effects of cocaine in mice, using the conditioned place preference (CPP) paradigm. Cocaine-induced CPP was studied pairing this drug with different memantine or CNQX doses during either the acquisition or the expression phase of the procedure. Once CPP was established, and the preference extinguished, reinstatement was induced by a priming dose of cocaine. Both antagonists, which in themselves do not present motivational actions on the preference shown by the animals, abolished the acquisition and expression of the cocaine-induced CPP. Neither of the antagonists precipitated reinstatement of the preference induced by cocaine but memantine blocked the cocaine-primed reinstatement. Our results suggest that cocaine-induced CPP and reinstatement is largely dependent on glutamate neurotransmission, and confer a putative role for memantine among the tools useful for cocaine management and treatment. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17395352/Effect_of_memantine_and_CNQX_in_the_acquisition_expression_and_reinstatement_of_cocaine_induced_conditioned_place_preference_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00071-1 DB - PRIME DP - Unbound Medicine ER -