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Glycated haemoglobin levels are related to chronic subclinical inflammation in renal transplant recipients without pre-existing or new onset diabetes.
Nephrol Dial Transplant. 2007 Jul; 22(7):1994-9.ND

Abstract

BACKGROUND

C-reactive protein (CRP), a marker of chronic subclinical inflammation (CSI), is related to cardiovascular mortality in the general and renal transplant populations. In the general population, high CRP levels are associated with pre-diabetic glucose homeostasis alterations which may contribute to the proatherogenic effect of CSI.

METHODS

We studied 134 consecutive renal transplant recipients without pre-existing or new onset diabetes. CRP, oral glucose tolerance test, insulin sensitivity and HbA1c were measured.

RESULTS

Among CRP tertiles, fasting glucose and glucose after 120 min were not different. However, HbA1c was higher (4.9+/-0.6; 5.2+/-0.5; 5.4+/-0.5; P=0.005] and insulin sensitivity lower (McAuley index: 7.2+/-2; 6.8+/-2; 6.2+/-1.3; P=0.042) in the third CRP tertile. In addition, HDL-cholesterol was lower and triglycerides and body mass index (BMI) higher in the third tertile. Consequently, metabolic syndrome was more prevalent in the upper CRP tertiles [11 (25%); 19 (43%); 22 (50%); P=0.01). In multivariate analyses, HbA1c was related to higher CRP levels (standardized beta coefficient=0.21, P=0.013), independently of BMI (standardized beta coefficient=0.24, P=0.005) and triglycerides (standardized beta coefficient=0.18; P=0.03).

CONCLUSIONS

Subclinical glucose homeostasis alterations are related to chronic inflammation in renal transplant recipients without pre-existing or new onset diabetes and may contribute to their high cardiovascular mortality.

Authors+Show Affiliations

Research Unit, Hospital Universitario de Canarias, Ofra S/N, 38320, La Laguna, Tenerife, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17395658

Citation

Porrini, Esteban, et al. "Glycated Haemoglobin Levels Are Related to Chronic Subclinical Inflammation in Renal Transplant Recipients Without Pre-existing or New Onset Diabetes." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 22, no. 7, 2007, pp. 1994-9.
Porrini E, Gomez MD, Alvarez A, et al. Glycated haemoglobin levels are related to chronic subclinical inflammation in renal transplant recipients without pre-existing or new onset diabetes. Nephrol Dial Transplant. 2007;22(7):1994-9.
Porrini, E., Gomez, M. D., Alvarez, A., Cobo, M., Gonzalez-Posada, J. M., Perez, L., Hortal, L., García, J. J., Dolores Checa, M., Morales, A., Hernández, D., & Torres, A. (2007). Glycated haemoglobin levels are related to chronic subclinical inflammation in renal transplant recipients without pre-existing or new onset diabetes. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 22(7), 1994-9.
Porrini E, et al. Glycated Haemoglobin Levels Are Related to Chronic Subclinical Inflammation in Renal Transplant Recipients Without Pre-existing or New Onset Diabetes. Nephrol Dial Transplant. 2007;22(7):1994-9. PubMed PMID: 17395658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycated haemoglobin levels are related to chronic subclinical inflammation in renal transplant recipients without pre-existing or new onset diabetes. AU - Porrini,Esteban, AU - Gomez,Maribel Diaz, AU - Alvarez,Alejandra, AU - Cobo,Marian, AU - Gonzalez-Posada,Jose Manuel, AU - Perez,Lourdes, AU - Hortal,Luis, AU - García,José J, AU - Dolores Checa,María, AU - Morales,Adelaida, AU - Hernández,Domingo, AU - Torres,Armando, Y1 - 2007/03/29/ PY - 2007/3/31/pubmed PY - 2007/10/17/medline PY - 2007/3/31/entrez SP - 1994 EP - 9 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 22 IS - 7 N2 - BACKGROUND: C-reactive protein (CRP), a marker of chronic subclinical inflammation (CSI), is related to cardiovascular mortality in the general and renal transplant populations. In the general population, high CRP levels are associated with pre-diabetic glucose homeostasis alterations which may contribute to the proatherogenic effect of CSI. METHODS: We studied 134 consecutive renal transplant recipients without pre-existing or new onset diabetes. CRP, oral glucose tolerance test, insulin sensitivity and HbA1c were measured. RESULTS: Among CRP tertiles, fasting glucose and glucose after 120 min were not different. However, HbA1c was higher (4.9+/-0.6; 5.2+/-0.5; 5.4+/-0.5; P=0.005] and insulin sensitivity lower (McAuley index: 7.2+/-2; 6.8+/-2; 6.2+/-1.3; P=0.042) in the third CRP tertile. In addition, HDL-cholesterol was lower and triglycerides and body mass index (BMI) higher in the third tertile. Consequently, metabolic syndrome was more prevalent in the upper CRP tertiles [11 (25%); 19 (43%); 22 (50%); P=0.01). In multivariate analyses, HbA1c was related to higher CRP levels (standardized beta coefficient=0.21, P=0.013), independently of BMI (standardized beta coefficient=0.24, P=0.005) and triglycerides (standardized beta coefficient=0.18; P=0.03). CONCLUSIONS: Subclinical glucose homeostasis alterations are related to chronic inflammation in renal transplant recipients without pre-existing or new onset diabetes and may contribute to their high cardiovascular mortality. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/17395658/Glycated_haemoglobin_levels_are_related_to_chronic_subclinical_inflammation_in_renal_transplant_recipients_without_pre_existing_or_new_onset_diabetes_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfm067 DB - PRIME DP - Unbound Medicine ER -