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Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases.
Nat Rev Drug Discov. 2007 Apr; 6(4):313-25.NR

Abstract

Immunological activation of mast cells is an important trigger in the cascade of inflammatory events leading to the manifestation of allergic diseases. Pharmacological studies using the recently discovered DP(1) and CRTH2 antagonists combined with genetic analysis support the view that these receptors have a pivotal role in mediating aspects of allergic diseases that are resistant to current therapy. This Review focuses on the emerging roles that DP(1) and CRTH2 (also known as DP(2)) have in acute and chronic aspects of allergic diseases and proposes that, rather than having opposing actions, these receptors have complementary roles in the initiation and maintenance of the allergy state. We also discuss recent progress in the discovery and development of selective antagonists of these receptors.

Authors+Show Affiliations

Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK. r.pettipher@oxagen.co.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17396136

Citation

Pettipher, Roy, et al. "Antagonism of the Prostaglandin D2 Receptors DP1 and CRTH2 as an Approach to Treat Allergic Diseases." Nature Reviews. Drug Discovery, vol. 6, no. 4, 2007, pp. 313-25.
Pettipher R, Hansel TT, Armer R. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov. 2007;6(4):313-25.
Pettipher, R., Hansel, T. T., & Armer, R. (2007). Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nature Reviews. Drug Discovery, 6(4), 313-25.
Pettipher R, Hansel TT, Armer R. Antagonism of the Prostaglandin D2 Receptors DP1 and CRTH2 as an Approach to Treat Allergic Diseases. Nat Rev Drug Discov. 2007;6(4):313-25. PubMed PMID: 17396136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. AU - Pettipher,Roy, AU - Hansel,Trevor T, AU - Armer,Richard, PY - 2007/3/31/pubmed PY - 2007/5/9/medline PY - 2007/3/31/entrez SP - 313 EP - 25 JF - Nature reviews. Drug discovery JO - Nat Rev Drug Discov VL - 6 IS - 4 N2 - Immunological activation of mast cells is an important trigger in the cascade of inflammatory events leading to the manifestation of allergic diseases. Pharmacological studies using the recently discovered DP(1) and CRTH2 antagonists combined with genetic analysis support the view that these receptors have a pivotal role in mediating aspects of allergic diseases that are resistant to current therapy. This Review focuses on the emerging roles that DP(1) and CRTH2 (also known as DP(2)) have in acute and chronic aspects of allergic diseases and proposes that, rather than having opposing actions, these receptors have complementary roles in the initiation and maintenance of the allergy state. We also discuss recent progress in the discovery and development of selective antagonists of these receptors. SN - 1474-1776 UR - https://www.unboundmedicine.com/medline/citation/17396136/Antagonism_of_the_prostaglandin_D2_receptors_DP1_and_CRTH2_as_an_approach_to_treat_allergic_diseases_ L2 - http://dx.doi.org/10.1038/nrd2266 DB - PRIME DP - Unbound Medicine ER -