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Biomarkers of contaminant exposure in Northern Pike (Esox lucius) from the Yukon River Basin, Alaska.
Arch Environ Contam Toxicol. 2007 May; 52(4):549-62.AE

Abstract

As part of a larger investigation, northern pike (n = 158; Esox lucius) were collected from ten sites in the Yukon River Basin (YRB), Alaska, to document biomarkers and their correlations with organochlorine pesticide (total p,p'-DDT, total chlordane, dieldrin, and toxaphene), total polychlorinated biphenyls (PCBs), and elemental contaminant (arsenic, cadmium, copper, lead, total mercury, selenium, and zinc) concentrations. A suite of biomarkers including somatic indices, hepatic 7-ethoxyresorufin O-deethylase (EROD) activity, vitellogenin concentrations, steroid hormone (17B- ustradiol and 16-kebtestosteront) concentrations, splenic macrophage aggregates (MAs), oocyte atresia, and other microscopic anomalies in various tissues were documented in YRB pike. Mean condition factor (0.50 to 0.68), hepatosomatic index (1.00% to 3.56%), and splenosomatic index (0.09% to 0.18%) were not anomalous at any site nor correlated with any contaminant concentration. Mean EROD activity (0.71 to 17.51 pmol/min/mg protein) was similar to basal activity levels previously measured in pike and was positively correlated with selenium concentrations (r = 0.88, P < 0.01). Vitellogenin concentrations in female (0.09 to 5.32 mg/mL) and male (<0.0005 to 0.097 mg/mL) pike were not correlated with any contaminant, but vitellogenin concentrations >0.01 mg/mL in male pike from multiple sites indicated exposure to estrogenic compounds. Mean steroid hormone concentrations and percent oocyte atresia were not anomalous in pike from any YRB site. Few site differences were significant for mean MA density (1.86 to 6.42 MA/mm(2)), size (812 to 1481 microm(2)), and tissue occupied (MA-%; 0.24% to 0.75%). A linear regression between MA-% and total PCBs was significant, although PCB concentrations were generally low in YRB pike (< or =63 ng/g), and MA-% values in female pike (0.24% to 0.54%) were lower than in male pike (0.32% to 0.75%) at similar PCB concentrations. Greater numbers of MAs were found as zinc concentrations increased in YRB female pike, but it is unlikely that this is a causative relationship. Histological abnormalities observed in gill, liver, spleen, and kidney tissues were not likely a result of contaminant exposure but provide information on the general health of YRB pike. The most common histologic anomalies were parasitic infestations in various organs and developing nephrons and nephrocalcinosis in posterior kidney tissues. Overall, few biomarker responses in YRB pike were correlated with chemical contaminant concentrations, and YRB pike generally appeared to be healthy with no site having multiple anomalous biomarker responses.

Authors+Show Affiliations

Columbia Environmental Research Center, United States Geological Survey, Columbia, MO 65201, USA. jhinck@usgs.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17396212

Citation

Hinck, J E., et al. "Biomarkers of Contaminant Exposure in Northern Pike (Esox Lucius) From the Yukon River Basin, Alaska." Archives of Environmental Contamination and Toxicology, vol. 52, no. 4, 2007, pp. 549-62.
Hinck JE, Blazer VS, Denslow ND, et al. Biomarkers of contaminant exposure in Northern Pike (Esox lucius) from the Yukon River Basin, Alaska. Arch Environ Contam Toxicol. 2007;52(4):549-62.
Hinck, J. E., Blazer, V. S., Denslow, N. D., Myers, M. S., Gross, T. S., & Tillitt, D. E. (2007). Biomarkers of contaminant exposure in Northern Pike (Esox lucius) from the Yukon River Basin, Alaska. Archives of Environmental Contamination and Toxicology, 52(4), 549-62.
Hinck JE, et al. Biomarkers of Contaminant Exposure in Northern Pike (Esox Lucius) From the Yukon River Basin, Alaska. Arch Environ Contam Toxicol. 2007;52(4):549-62. PubMed PMID: 17396212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomarkers of contaminant exposure in Northern Pike (Esox lucius) from the Yukon River Basin, Alaska. AU - Hinck,J E, AU - Blazer,V S, AU - Denslow,N D, AU - Myers,M S, AU - Gross,T S, AU - Tillitt,D E, Y1 - 2007/03/29/ PY - 2006/06/29/received PY - 2006/10/09/accepted PY - 2007/3/31/pubmed PY - 2007/9/19/medline PY - 2007/3/31/entrez SP - 549 EP - 62 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 52 IS - 4 N2 - As part of a larger investigation, northern pike (n = 158; Esox lucius) were collected from ten sites in the Yukon River Basin (YRB), Alaska, to document biomarkers and their correlations with organochlorine pesticide (total p,p'-DDT, total chlordane, dieldrin, and toxaphene), total polychlorinated biphenyls (PCBs), and elemental contaminant (arsenic, cadmium, copper, lead, total mercury, selenium, and zinc) concentrations. A suite of biomarkers including somatic indices, hepatic 7-ethoxyresorufin O-deethylase (EROD) activity, vitellogenin concentrations, steroid hormone (17B- ustradiol and 16-kebtestosteront) concentrations, splenic macrophage aggregates (MAs), oocyte atresia, and other microscopic anomalies in various tissues were documented in YRB pike. Mean condition factor (0.50 to 0.68), hepatosomatic index (1.00% to 3.56%), and splenosomatic index (0.09% to 0.18%) were not anomalous at any site nor correlated with any contaminant concentration. Mean EROD activity (0.71 to 17.51 pmol/min/mg protein) was similar to basal activity levels previously measured in pike and was positively correlated with selenium concentrations (r = 0.88, P < 0.01). Vitellogenin concentrations in female (0.09 to 5.32 mg/mL) and male (<0.0005 to 0.097 mg/mL) pike were not correlated with any contaminant, but vitellogenin concentrations >0.01 mg/mL in male pike from multiple sites indicated exposure to estrogenic compounds. Mean steroid hormone concentrations and percent oocyte atresia were not anomalous in pike from any YRB site. Few site differences were significant for mean MA density (1.86 to 6.42 MA/mm(2)), size (812 to 1481 microm(2)), and tissue occupied (MA-%; 0.24% to 0.75%). A linear regression between MA-% and total PCBs was significant, although PCB concentrations were generally low in YRB pike (< or =63 ng/g), and MA-% values in female pike (0.24% to 0.54%) were lower than in male pike (0.32% to 0.75%) at similar PCB concentrations. Greater numbers of MAs were found as zinc concentrations increased in YRB female pike, but it is unlikely that this is a causative relationship. Histological abnormalities observed in gill, liver, spleen, and kidney tissues were not likely a result of contaminant exposure but provide information on the general health of YRB pike. The most common histologic anomalies were parasitic infestations in various organs and developing nephrons and nephrocalcinosis in posterior kidney tissues. Overall, few biomarker responses in YRB pike were correlated with chemical contaminant concentrations, and YRB pike generally appeared to be healthy with no site having multiple anomalous biomarker responses. SN - 0090-4341 UR - https://www.unboundmedicine.com/medline/citation/17396212/Biomarkers_of_contaminant_exposure_in_Northern_Pike__Esox_lucius__from_the_Yukon_River_Basin_Alaska_ L2 - https://dx.doi.org/10.1007/s00244-006-0134-z DB - PRIME DP - Unbound Medicine ER -