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Prevalence of peripheral arterial disease and risk factors in persons aged 60 and older: data from the National Health and Nutrition Examination Survey 1999-2004.
J Am Geriatr Soc. 2007 Apr; 55(4):583-9.JA

Abstract

OBJECTIVES

Peripheral arterial disease (PAD) is associated with significant cardiovascular morbidity and mortality. The study objectives were to examine the prevalence of PAD and associated risk factors.

DESIGN

A cross-sectional nationally representative health examination survey.

SETTING

The National Health and Nutrition Examination Survey 1999-2004.

PARTICIPANTS

Data from 3,947 men and women aged 60 and older who received a lower extremity examination.

MEASUREMENTS

The main outcome was PAD, defined as an ankle-brachial blood pressure index of less than 0.9 in either leg.

RESULTS

In older U.S. adults, PAD prevalence was 12.2% (95% confidence interval (CI) = 10.9-13.5%). PAD prevalence increased with age. PAD prevalence was 7.0% (95% CI = 5.6-8.4%) for those aged 60 to 69, 12.5% (95% CI = 10.4-14.6%), and 23.2% (95% CI = 19.8-26.7%) for those aged 70 to 79 and 80 and older. Age-adjusted estimates show that non-Hispanic black men and women and Mexican-American women had a higher prevalence of PAD than non-Hispanic white men and women (19.2%, 95% CI = 13.7-24.6%; 19.3%, 95% CI = 13.3-25.2%; and 15.6%, 95% CI = 12.7-18.6%, respectively). The results of the fully adjusted model show that current smoking (OR = 5.48, 95% CI = 3.60-8.35), previous smoking (OR = 1.94, 95% CI = 1.39-2.69), diabetes mellitus (OR = 1.81, 95% CI = 1.12-2.91), low kidney function (OR = 2.69, 95% CI = 1.58-4.56), mildly decreased kidney function (OR = 1.71, 95% CI = 1.22-2.38), high-sensitivity C-reactive protein greater than 3.0 mg/L (OR = 2.69, 95% CI = 1.24-5.85), treated but not controlled hypertension (OR = 1.95, 95% CI = 1.40-2.72), and untreated hypertension (OR = 1.68, 95% CI = 1.13-2.50) were all significantly associated with prevalent PAD.

CONCLUSION

PAD prevalence increases with age and is associated with treatable risk factors for cardiovascular disease.

Authors+Show Affiliations

Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA. yxo1@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17397438

Citation

Ostchega, Yechiam, et al. "Prevalence of Peripheral Arterial Disease and Risk Factors in Persons Aged 60 and Older: Data From the National Health and Nutrition Examination Survey 1999-2004." Journal of the American Geriatrics Society, vol. 55, no. 4, 2007, pp. 583-9.
Ostchega Y, Paulose-Ram R, Dillon CF, et al. Prevalence of peripheral arterial disease and risk factors in persons aged 60 and older: data from the National Health and Nutrition Examination Survey 1999-2004. J Am Geriatr Soc. 2007;55(4):583-9.
Ostchega, Y., Paulose-Ram, R., Dillon, C. F., Gu, Q., & Hughes, J. P. (2007). Prevalence of peripheral arterial disease and risk factors in persons aged 60 and older: data from the National Health and Nutrition Examination Survey 1999-2004. Journal of the American Geriatrics Society, 55(4), 583-9.
Ostchega Y, et al. Prevalence of Peripheral Arterial Disease and Risk Factors in Persons Aged 60 and Older: Data From the National Health and Nutrition Examination Survey 1999-2004. J Am Geriatr Soc. 2007;55(4):583-9. PubMed PMID: 17397438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of peripheral arterial disease and risk factors in persons aged 60 and older: data from the National Health and Nutrition Examination Survey 1999-2004. AU - Ostchega,Yechiam, AU - Paulose-Ram,Ryne, AU - Dillon,Charles F, AU - Gu,Qiuping, AU - Hughes,Jeffery P, PY - 2007/4/3/pubmed PY - 2007/5/18/medline PY - 2007/4/3/entrez SP - 583 EP - 9 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 55 IS - 4 N2 - OBJECTIVES: Peripheral arterial disease (PAD) is associated with significant cardiovascular morbidity and mortality. The study objectives were to examine the prevalence of PAD and associated risk factors. DESIGN: A cross-sectional nationally representative health examination survey. SETTING: The National Health and Nutrition Examination Survey 1999-2004. PARTICIPANTS: Data from 3,947 men and women aged 60 and older who received a lower extremity examination. MEASUREMENTS: The main outcome was PAD, defined as an ankle-brachial blood pressure index of less than 0.9 in either leg. RESULTS: In older U.S. adults, PAD prevalence was 12.2% (95% confidence interval (CI) = 10.9-13.5%). PAD prevalence increased with age. PAD prevalence was 7.0% (95% CI = 5.6-8.4%) for those aged 60 to 69, 12.5% (95% CI = 10.4-14.6%), and 23.2% (95% CI = 19.8-26.7%) for those aged 70 to 79 and 80 and older. Age-adjusted estimates show that non-Hispanic black men and women and Mexican-American women had a higher prevalence of PAD than non-Hispanic white men and women (19.2%, 95% CI = 13.7-24.6%; 19.3%, 95% CI = 13.3-25.2%; and 15.6%, 95% CI = 12.7-18.6%, respectively). The results of the fully adjusted model show that current smoking (OR = 5.48, 95% CI = 3.60-8.35), previous smoking (OR = 1.94, 95% CI = 1.39-2.69), diabetes mellitus (OR = 1.81, 95% CI = 1.12-2.91), low kidney function (OR = 2.69, 95% CI = 1.58-4.56), mildly decreased kidney function (OR = 1.71, 95% CI = 1.22-2.38), high-sensitivity C-reactive protein greater than 3.0 mg/L (OR = 2.69, 95% CI = 1.24-5.85), treated but not controlled hypertension (OR = 1.95, 95% CI = 1.40-2.72), and untreated hypertension (OR = 1.68, 95% CI = 1.13-2.50) were all significantly associated with prevalent PAD. CONCLUSION: PAD prevalence increases with age and is associated with treatable risk factors for cardiovascular disease. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/17397438/Prevalence_of_peripheral_arterial_disease_and_risk_factors_in_persons_aged_60_and_older:_data_from_the_National_Health_and_Nutrition_Examination_Survey_1999_2004_ L2 - https://doi.org/10.1111/j.1532-5415.2007.01123.x DB - PRIME DP - Unbound Medicine ER -