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Frequency doubling perimetry and short-wavelength automated perimetry to detect early glaucoma.
Ophthalmology. 2007 May; 114(5):931-7.O

Abstract

PURPOSE

To compare the ability of short-wavelength automated perimetry (SWAP) and frequency doubling perimetry (FDP) to detect early glaucoma damage.

DESIGN

Prospective case-control study using a comparative case series.

PARTICIPANTS

Forty-two patients with preperimetric glaucomatous optic nerve damage and a normal standard achromatic perimetry (SAP) in 1 eye, but with contralateral SAP abnormalities, and 35 normals.

METHODS

Forty-two patients and 35 normals underwent SWAP and FDP (Humphrey 24-2; Carl Zeiss Meditec, Inc., Dublin, CA). Correlations of mean deviation (MD) and pattern standard deviation (PSD) of the 2 groups were calculated. The number of defects at P<0.05 and P<0.01 on total deviation (TD) and pattern deviation (PD) plots were compared. Diagnostic precision and agreement on location of abnormalities were determined.

MAIN OUTCOME MEASURES

Correlations and comparisons of global indices between SWAP and FDP: MD, PSD, TD, and PD abnormal number of points.

RESULTS

Significant correlations in the glaucoma group were found between SWAP and FDP for MD (r = 0.54; P<0.008) and PSD (r = 0.49; P<0.001). Defects on the TD and PD plots were detected more frequently by FDP in the glaucoma group, although they were significant only for PD at P<0.01 (P = 0.024). Areas under receiver operator characteristic curves for MD of SWAP and PSD of FDP were 0.74 and 0.67, respectively (P = 0.37). Using defined defect criteria, FDP had a significantly higher sensitivity (72% vs. 54%; P = 0.02) and similar specificity (53% vs. 44%; P = 0.12) compared with SWAP. Agreement on defect location was moderate (kappa, 0.46). Testing time for SWAP was longer than for FDP in both glaucomatous and normal eyes (P<0.001).

CONCLUSIONS

Short-wavelength automated perimetry and FDP showed similar ability to detect visual dysfunction in patients with preperimetric glaucoma. Long-term follow-up is required to define their role in predicting subsequent SAP defects.

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Authors+Show Affiliations

Leeprechanon N
Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.
Giaconi JA
No affiliation info available
Manassakorn A
No affiliation info available
Hoffman D
No affiliation info available
Caprioli J
No affiliation info available

MeSH

AdultAgedCase-Control StudiesFemaleGlaucomaHumansIntraocular PressureMaleMiddle AgedOptic Nerve DiseasesProspective StudiesROC CurveVision DisordersVisual AcuityVisual Field TestsVisual Fields

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17397926

Citation

Leeprechanon, Narakorn, et al. "Frequency Doubling Perimetry and Short-wavelength Automated Perimetry to Detect Early Glaucoma." Ophthalmology, vol. 114, no. 5, 2007, pp. 931-7.
Leeprechanon N, Giaconi JA, Manassakorn A, et al. Frequency doubling perimetry and short-wavelength automated perimetry to detect early glaucoma. Ophthalmology. 2007;114(5):931-7.
Leeprechanon, N., Giaconi, J. A., Manassakorn, A., Hoffman, D., & Caprioli, J. (2007). Frequency doubling perimetry and short-wavelength automated perimetry to detect early glaucoma. Ophthalmology, 114(5), 931-7.
Leeprechanon N, et al. Frequency Doubling Perimetry and Short-wavelength Automated Perimetry to Detect Early Glaucoma. Ophthalmology. 2007;114(5):931-7. PubMed PMID: 17397926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency doubling perimetry and short-wavelength automated perimetry to detect early glaucoma. AU - Leeprechanon,Narakorn, AU - Giaconi,Joann A, AU - Manassakorn,Anita, AU - Hoffman,Douglas, AU - Caprioli,Joseph, Y1 - 2007/03/30/ PY - 2006/09/19/received PY - 2007/01/09/revised PY - 2007/01/09/accepted PY - 2007/4/3/pubmed PY - 2007/5/11/medline PY - 2007/4/3/entrez SP - 931 EP - 7 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 5 N2 - PURPOSE: To compare the ability of short-wavelength automated perimetry (SWAP) and frequency doubling perimetry (FDP) to detect early glaucoma damage. DESIGN: Prospective case-control study using a comparative case series. PARTICIPANTS: Forty-two patients with preperimetric glaucomatous optic nerve damage and a normal standard achromatic perimetry (SAP) in 1 eye, but with contralateral SAP abnormalities, and 35 normals. METHODS: Forty-two patients and 35 normals underwent SWAP and FDP (Humphrey 24-2; Carl Zeiss Meditec, Inc., Dublin, CA). Correlations of mean deviation (MD) and pattern standard deviation (PSD) of the 2 groups were calculated. The number of defects at P<0.05 and P<0.01 on total deviation (TD) and pattern deviation (PD) plots were compared. Diagnostic precision and agreement on location of abnormalities were determined. MAIN OUTCOME MEASURES: Correlations and comparisons of global indices between SWAP and FDP: MD, PSD, TD, and PD abnormal number of points. RESULTS: Significant correlations in the glaucoma group were found between SWAP and FDP for MD (r = 0.54; P<0.008) and PSD (r = 0.49; P<0.001). Defects on the TD and PD plots were detected more frequently by FDP in the glaucoma group, although they were significant only for PD at P<0.01 (P = 0.024). Areas under receiver operator characteristic curves for MD of SWAP and PSD of FDP were 0.74 and 0.67, respectively (P = 0.37). Using defined defect criteria, FDP had a significantly higher sensitivity (72% vs. 54%; P = 0.02) and similar specificity (53% vs. 44%; P = 0.12) compared with SWAP. Agreement on defect location was moderate (kappa, 0.46). Testing time for SWAP was longer than for FDP in both glaucomatous and normal eyes (P<0.001). CONCLUSIONS: Short-wavelength automated perimetry and FDP showed similar ability to detect visual dysfunction in patients with preperimetric glaucoma. Long-term follow-up is required to define their role in predicting subsequent SAP defects. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17397926/Frequency_doubling_perimetry_and_short_wavelength_automated_perimetry_to_detect_early_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00040-1 DB - PRIME DP - Unbound Medicine ER -