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Dissolution test for citalopram in tablets and comparison of in vitro dissolution profiles.
Eur J Pharm Biopharm. 2007 Sep; 67(2):524-30.EJ

Abstract

A dissolution test for tablets containing 20 mg of citalopram was developed and validated using a reverse-phase liquid chromatographic method and this dissolution test was applied to compare dissolution profiles. The sink conditions, filters, stability of the drug and specificity on different dissolution media were tested to choose a discriminatory dissolution method which uses USP apparatus 1 with baskets rotating at 50 rpm, 900 ml of deaerated 0.1 M hydrochloric acid (HCl) as the dissolution medium. The quantitation method was also adapted and validated. The parameters of difference factor, similar factor, according to current FDA guidelines, and dissolution efficiency were employed to compare dissolution profiles. The dissolution test developed and validated was adequate for its purposes and could be applied for quality control of citalopram tablets, since there is no monograph to citalopram in tablets, this work can be used to help pharmocopoeias.

Authors+Show Affiliations

Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. juliamenegola@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17398084

Citation

Menegola, Júlia, et al. "Dissolution Test for Citalopram in Tablets and Comparison of in Vitro Dissolution Profiles." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 67, no. 2, 2007, pp. 524-30.
Menegola J, Steppe M, Schapoval EE. Dissolution test for citalopram in tablets and comparison of in vitro dissolution profiles. Eur J Pharm Biopharm. 2007;67(2):524-30.
Menegola, J., Steppe, M., & Schapoval, E. E. (2007). Dissolution test for citalopram in tablets and comparison of in vitro dissolution profiles. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 67(2), 524-30.
Menegola J, Steppe M, Schapoval EE. Dissolution Test for Citalopram in Tablets and Comparison of in Vitro Dissolution Profiles. Eur J Pharm Biopharm. 2007;67(2):524-30. PubMed PMID: 17398084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissolution test for citalopram in tablets and comparison of in vitro dissolution profiles. AU - Menegola,Júlia, AU - Steppe,Martin, AU - Schapoval,Elfrides E S, Y1 - 2007/02/20/ PY - 2007/01/12/received PY - 2007/02/12/revised PY - 2007/02/14/accepted PY - 2007/4/3/pubmed PY - 2007/12/13/medline PY - 2007/4/3/entrez SP - 524 EP - 30 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 67 IS - 2 N2 - A dissolution test for tablets containing 20 mg of citalopram was developed and validated using a reverse-phase liquid chromatographic method and this dissolution test was applied to compare dissolution profiles. The sink conditions, filters, stability of the drug and specificity on different dissolution media were tested to choose a discriminatory dissolution method which uses USP apparatus 1 with baskets rotating at 50 rpm, 900 ml of deaerated 0.1 M hydrochloric acid (HCl) as the dissolution medium. The quantitation method was also adapted and validated. The parameters of difference factor, similar factor, according to current FDA guidelines, and dissolution efficiency were employed to compare dissolution profiles. The dissolution test developed and validated was adequate for its purposes and could be applied for quality control of citalopram tablets, since there is no monograph to citalopram in tablets, this work can be used to help pharmocopoeias. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/17398084/Dissolution_test_for_citalopram_in_tablets_and_comparison_of_in_vitro_dissolution_profiles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(07)00068-9 DB - PRIME DP - Unbound Medicine ER -