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Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia.
Trends Neurosci. 2007 May; 30(5):236-43.TN

Abstract

The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by L-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that the motor complications of L-DOPA pharmacotherapy are triggered by transient and large changes in extracellular DA levels. The disruption of presynaptic DA homeostasis sets in motion a cascade of postsynaptic alterations, which prime the brain for a complicated motor response to dopaminomimetic treatment. L-DOPA-induced dyskinesia provides a paradigm to study how the dysregulation of DA release and clearance results in maladaptive neuroplasticity sustaining abnormal patterns of movement.

Authors+Show Affiliations

Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, BMC F11, S.221 84 Lund, Sweden. Angela.Cenci_Nilsson@med.lu.se

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17400300

Citation

Cenci, M Angela. "Dopamine Dysregulation of Movement Control in L-DOPA-induced Dyskinesia." Trends in Neurosciences, vol. 30, no. 5, 2007, pp. 236-43.
Cenci MA. Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia. Trends Neurosci. 2007;30(5):236-43.
Cenci, M. A. (2007). Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia. Trends in Neurosciences, 30(5), 236-43.
Cenci MA. Dopamine Dysregulation of Movement Control in L-DOPA-induced Dyskinesia. Trends Neurosci. 2007;30(5):236-43. PubMed PMID: 17400300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia. A1 - Cenci,M Angela, Y1 - 2007/04/02/ PY - 2006/12/01/received PY - 2007/02/07/revised PY - 2007/03/19/accepted PY - 2007/4/3/pubmed PY - 2007/7/13/medline PY - 2007/4/3/entrez SP - 236 EP - 43 JF - Trends in neurosciences JO - Trends Neurosci VL - 30 IS - 5 N2 - The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by L-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that the motor complications of L-DOPA pharmacotherapy are triggered by transient and large changes in extracellular DA levels. The disruption of presynaptic DA homeostasis sets in motion a cascade of postsynaptic alterations, which prime the brain for a complicated motor response to dopaminomimetic treatment. L-DOPA-induced dyskinesia provides a paradigm to study how the dysregulation of DA release and clearance results in maladaptive neuroplasticity sustaining abnormal patterns of movement. SN - 0166-2236 UR - https://www.unboundmedicine.com/medline/citation/17400300/Dopamine_dysregulation_of_movement_control_in_L_DOPA_induced_dyskinesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-2236(07)00066-5 DB - PRIME DP - Unbound Medicine ER -