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The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease.
J Mol Neurosci 2006; 30(3):267-71JM

Abstract

Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi2 = 6.61, df = 2, p = 0.037 by genotype; chi2 = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi2 = 6.59, df = 1, p =0.01, OR = 2.91, 95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi2 = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39, 95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.

Authors+Show Affiliations

Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17401152

Citation

Wang, Binbin, et al. "The Insertion Polymorphism in Angiotensin-converting Enzyme Gene Associated With the APOE Epsilon 4 Allele Increases the Risk of Late-onset Alzheimer Disease." Journal of Molecular Neuroscience : MN, vol. 30, no. 3, 2006, pp. 267-71.
Wang B, Jin F, Yang Z, et al. The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. J Mol Neurosci. 2006;30(3):267-71.
Wang, B., Jin, F., Yang, Z., Lu, Z., Kan, R., Li, S., ... Wang, L. (2006). The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. Journal of Molecular Neuroscience : MN, 30(3), pp. 267-71.
Wang B, et al. The Insertion Polymorphism in Angiotensin-converting Enzyme Gene Associated With the APOE Epsilon 4 Allele Increases the Risk of Late-onset Alzheimer Disease. J Mol Neurosci. 2006;30(3):267-71. PubMed PMID: 17401152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. AU - Wang,Binbin, AU - Jin,Feng, AU - Yang,Ze, AU - Lu,Zeping, AU - Kan,Rui, AU - Li,Shu, AU - Zheng,Chenguang, AU - Wang,Li, PY - 1999/11/30/received PY - 1999/11/30/revised PY - 1999/11/30/accepted PY - 2007/4/3/pubmed PY - 2007/5/26/medline PY - 2007/4/3/entrez SP - 267 EP - 71 JF - Journal of molecular neuroscience : MN JO - J. Mol. Neurosci. VL - 30 IS - 3 N2 - Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi2 = 6.61, df = 2, p = 0.037 by genotype; chi2 = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi2 = 6.59, df = 1, p =0.01, OR = 2.91, 95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi2 = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39, 95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD. SN - 0895-8696 UR - https://www.unboundmedicine.com/medline/citation/17401152/The_insertion_polymorphism_in_angiotensin_converting_enzyme_gene_associated_with_the_APOE_epsilon_4_allele_increases_the_risk_of_late_onset_Alzheimer_disease_ L2 - https://dx.doi.org/10.1385/JMN:30:3:267 DB - PRIME DP - Unbound Medicine ER -