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Microalbuminuria and clinical correlates in black African patients with type 2 diabetes.
West Afr J Med 2006 Oct-Dec; 25(4):279-83WA

Abstract

BACKGROUND

Diabetes mellitus is a major cause of morbidity and mortality as a result of its complications. Long-term complications of diabetes mellitus have been linked to poor glycemic control. Diabetic nephropathy is the leading cause of end stage renal disease in the developed world and third leading cause in Nigeria. Various independent risk factors have been identified as predictors of diabetic nephropathy. One of such factors is urinary albumin excretion.

OBJECTIVE

This study set out to determine the prevalence of microalbuminuria (MA), glycemic control and the relationship between urinary albumin excretion (UAE) and other known predictors of diabetic nephropathy in type 2 diabetic patients with disease duration greater than 5 years.

STUDY DESIGN

Fifty non-proteinuric patients were selected consecutively for this cross-sectional study. Urinary albumin concentration was determined in a timed overnight urine sample by immunoturbidimetry and glycated haemoglobin was determined using boronate affinity method. Comparison was made between the patients with microalbuminuria and those with normal albumin excretion and the most likely predictors of urinary albumin excretion were determined.

RESULTS

Fifty-two percent of the patients studied had good glycaemic control (HbA1c < 7%) while 83% had microalbuminuria (UAE 20-200 mg/min). There was no significant correlation between the UAE and the HbA1c. UAE however correlated significantly with the age and diastolic blood pressure (DBP) of the patients.

CONCLUSION

Almost half of the patient population had suboptimal glycemic control. There was a high prevalence of microalbuminuria amongst the patients studied. Significant predictors of UAE in this study were the age of the patients and DBP but not HbA1c.

Authors+Show Affiliations

Department of Medicine, University College Hospital, Ibadan, P. M. B. 5116, Dugbe, Ibadan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17402516

Citation

Adetunji, O R., et al. "Microalbuminuria and Clinical Correlates in Black African Patients With Type 2 Diabetes." West African Journal of Medicine, vol. 25, no. 4, 2006, pp. 279-83.
Adetunji OR, Adeleye JO, Agada NO, et al. Microalbuminuria and clinical correlates in black African patients with type 2 diabetes. West Afr J Med. 2006;25(4):279-83.
Adetunji, O. R., Adeleye, J. O., Agada, N. O., & Salako, B. L. (2006). Microalbuminuria and clinical correlates in black African patients with type 2 diabetes. West African Journal of Medicine, 25(4), pp. 279-83.
Adetunji OR, et al. Microalbuminuria and Clinical Correlates in Black African Patients With Type 2 Diabetes. West Afr J Med. 2006;25(4):279-83. PubMed PMID: 17402516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microalbuminuria and clinical correlates in black African patients with type 2 diabetes. AU - Adetunji,O R, AU - Adeleye,J O, AU - Agada,N O, AU - Salako,B L, PY - 2007/4/4/pubmed PY - 2007/5/4/medline PY - 2007/4/4/entrez SP - 279 EP - 83 JF - West African journal of medicine JO - West Afr J Med VL - 25 IS - 4 N2 - BACKGROUND: Diabetes mellitus is a major cause of morbidity and mortality as a result of its complications. Long-term complications of diabetes mellitus have been linked to poor glycemic control. Diabetic nephropathy is the leading cause of end stage renal disease in the developed world and third leading cause in Nigeria. Various independent risk factors have been identified as predictors of diabetic nephropathy. One of such factors is urinary albumin excretion. OBJECTIVE: This study set out to determine the prevalence of microalbuminuria (MA), glycemic control and the relationship between urinary albumin excretion (UAE) and other known predictors of diabetic nephropathy in type 2 diabetic patients with disease duration greater than 5 years. STUDY DESIGN: Fifty non-proteinuric patients were selected consecutively for this cross-sectional study. Urinary albumin concentration was determined in a timed overnight urine sample by immunoturbidimetry and glycated haemoglobin was determined using boronate affinity method. Comparison was made between the patients with microalbuminuria and those with normal albumin excretion and the most likely predictors of urinary albumin excretion were determined. RESULTS: Fifty-two percent of the patients studied had good glycaemic control (HbA1c < 7%) while 83% had microalbuminuria (UAE 20-200 mg/min). There was no significant correlation between the UAE and the HbA1c. UAE however correlated significantly with the age and diastolic blood pressure (DBP) of the patients. CONCLUSION: Almost half of the patient population had suboptimal glycemic control. There was a high prevalence of microalbuminuria amongst the patients studied. Significant predictors of UAE in this study were the age of the patients and DBP but not HbA1c. SN - 0189-160X UR - https://www.unboundmedicine.com/medline/citation/17402516/Microalbuminuria_and_clinical_correlates_in_black_African_patients_with_type_2_diabetes_ L2 - http://www.diseaseinfosearch.org/result/2243 DB - PRIME DP - Unbound Medicine ER -