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Serum osteoprotegerin and its ligand in cirrhotic patients referred for orthotopic liver transplantation: relationship with metabolic bone disease.
Liver Int 2007; 27(4):492-7LI

Abstract

AIMS

A prospective study was carried out in 22 cirrhotic patients referred for orthotopic liver transplantation, in order to analyze serum osteoprotegerin (OPG) and RANKL levels and their relationship with metabolic bone disease.

METHODS

Serum levels of OPG and RANKL were measured in all patients as well as bone markers, serum parathyroid hormone and 25-hydroxyvitamin D levels. OPG and RANKL values were compared with those obtained in 29 healthy controls. Bone mineral density (BMD) of the lumbar spine and proximal femur was measured by dual X-ray absorptiometry and spinal X-rays were obtained to assess vertebral fractures.

RESULTS

Serum OPG levels were higher in cirrhotic patients than in controls (6.4+/-2 vs 2.7+/-0.7 pmol/l; P=0.001) and RANKL serum levels were lower in cirrhotic patients (0.215+/-0.6 vs 1.012+/-1.2 pmol/l; P=0.002), with an increased OPG:RANKL ratio when compared with the control group (280.3+/-334.5 vs 113+/-137.6; P=0.04). Ten patients had osteoporosis (45%) and up to 45% skeletal fractures. No differences were found in OPG levels between patients with and without osteoporosis by densitometric criteria or fractures. Negative correlations were found between OPG levels and femoral neck (R-0.46; P=0.03) and total hip BMD (R-0.48; P=0.025). By contrast, OPG values were not related to markers of bone turnover.

CONCLUSIONS

OPG values are elevated in cirrhotic patients before liver transplantation, particularly in those with low bone mass at the proximal femur.

Authors+Show Affiliations

Service of Rheumatology Unit, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain. 21607amb@comb.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17403189

Citation

Monegal, Ana, et al. "Serum Osteoprotegerin and Its Ligand in Cirrhotic Patients Referred for Orthotopic Liver Transplantation: Relationship With Metabolic Bone Disease." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 27, no. 4, 2007, pp. 492-7.
Monegal A, Navasa M, Peris P, et al. Serum osteoprotegerin and its ligand in cirrhotic patients referred for orthotopic liver transplantation: relationship with metabolic bone disease. Liver Int. 2007;27(4):492-7.
Monegal, A., Navasa, M., Peris, P., Alvarez, L., Pons, F., Rodés, J., & Guañabens, N. (2007). Serum osteoprotegerin and its ligand in cirrhotic patients referred for orthotopic liver transplantation: relationship with metabolic bone disease. Liver International : Official Journal of the International Association for the Study of the Liver, 27(4), pp. 492-7.
Monegal A, et al. Serum Osteoprotegerin and Its Ligand in Cirrhotic Patients Referred for Orthotopic Liver Transplantation: Relationship With Metabolic Bone Disease. Liver Int. 2007;27(4):492-7. PubMed PMID: 17403189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum osteoprotegerin and its ligand in cirrhotic patients referred for orthotopic liver transplantation: relationship with metabolic bone disease. AU - Monegal,Ana, AU - Navasa,Miquel, AU - Peris,Pilar, AU - Alvarez,Luisa, AU - Pons,Francesca, AU - Rodés,Joan, AU - Guañabens,Nuria, PY - 2007/4/4/pubmed PY - 2007/6/15/medline PY - 2007/4/4/entrez SP - 492 EP - 7 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int. VL - 27 IS - 4 N2 - AIMS: A prospective study was carried out in 22 cirrhotic patients referred for orthotopic liver transplantation, in order to analyze serum osteoprotegerin (OPG) and RANKL levels and their relationship with metabolic bone disease. METHODS: Serum levels of OPG and RANKL were measured in all patients as well as bone markers, serum parathyroid hormone and 25-hydroxyvitamin D levels. OPG and RANKL values were compared with those obtained in 29 healthy controls. Bone mineral density (BMD) of the lumbar spine and proximal femur was measured by dual X-ray absorptiometry and spinal X-rays were obtained to assess vertebral fractures. RESULTS: Serum OPG levels were higher in cirrhotic patients than in controls (6.4+/-2 vs 2.7+/-0.7 pmol/l; P=0.001) and RANKL serum levels were lower in cirrhotic patients (0.215+/-0.6 vs 1.012+/-1.2 pmol/l; P=0.002), with an increased OPG:RANKL ratio when compared with the control group (280.3+/-334.5 vs 113+/-137.6; P=0.04). Ten patients had osteoporosis (45%) and up to 45% skeletal fractures. No differences were found in OPG levels between patients with and without osteoporosis by densitometric criteria or fractures. Negative correlations were found between OPG levels and femoral neck (R-0.46; P=0.03) and total hip BMD (R-0.48; P=0.025). By contrast, OPG values were not related to markers of bone turnover. CONCLUSIONS: OPG values are elevated in cirrhotic patients before liver transplantation, particularly in those with low bone mass at the proximal femur. SN - 1478-3223 UR - https://www.unboundmedicine.com/medline/citation/17403189/Serum_osteoprotegerin_and_its_ligand_in_cirrhotic_patients_referred_for_orthotopic_liver_transplantation:_relationship_with_metabolic_bone_disease_ L2 - https://doi.org/10.1111/j.1478-3231.2007.01448.x DB - PRIME DP - Unbound Medicine ER -