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Model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor and its correlation with portal pressure in patients with liver cirrhosis.
Liver Int. 2007 May; 27(4):498-506.LI

Abstract

BACKGROUND

The models for end-stage liver disease (MELD) and serum sodium (SNa) are important prognostic markers in cirrhosis. A novel index, MELD to SNa ratio (MESO), was developed to amplify the opposing effect of MELD and SNa on outcome prediction.

METHODS

A total of 213 cirrhotic patients undergoing hepatic venous pressure gradient (HVPG) measurement were retrospectively analyzed.

RESULTS

The MESO index correlated with HVPG (r=0.258, P<0.001) and Child-Pugh score (rho=0.749, P<0.001). Using mortality as the end point, the area under receiver operating characteristic curve (AUC) was 0.860 for SNa, 0.795 for the MESO index and 0.789 for MELD (P values all >0.3) at 3 months. Among patients with Child-Pugh class A or B, the MESO index had a significantly higher AUC compared with MELD (0.80 vs. 0.766, P<0.001). A MESO index <1.6 identified 97% of patients who survived at 3 months and the predicted survival rate was 96.5%. In survival analysis, MESO index >1.6 independently predicted a higher mortality rate (relative risk: 3.32, P<0001) using the Cox model.

CONCLUSIONS

The MESO index, which takes into account the predictive power of both MELD and SNa, is a useful prognostic predictor for both short- and long-term survival in cirrhotic patients.

Authors+Show Affiliations

Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17403190

Citation

Huo, Teh-Ia, et al. "Model for End-stage Liver Disease Score to Serum Sodium Ratio Index as a Prognostic Predictor and Its Correlation With Portal Pressure in Patients With Liver Cirrhosis." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 27, no. 4, 2007, pp. 498-506.
Huo TI, Wang YW, Yang YY, et al. Model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor and its correlation with portal pressure in patients with liver cirrhosis. Liver Int. 2007;27(4):498-506.
Huo, T. I., Wang, Y. W., Yang, Y. Y., Lin, H. C., Lee, P. C., Hou, M. C., Lee, F. Y., & Lee, S. D. (2007). Model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor and its correlation with portal pressure in patients with liver cirrhosis. Liver International : Official Journal of the International Association for the Study of the Liver, 27(4), 498-506.
Huo TI, et al. Model for End-stage Liver Disease Score to Serum Sodium Ratio Index as a Prognostic Predictor and Its Correlation With Portal Pressure in Patients With Liver Cirrhosis. Liver Int. 2007;27(4):498-506. PubMed PMID: 17403190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor and its correlation with portal pressure in patients with liver cirrhosis. AU - Huo,Teh-Ia, AU - Wang,Ying-Wen, AU - Yang,Ying-Ying, AU - Lin,Han-Chieh, AU - Lee,Pui-Ching, AU - Hou,Ming-Chih, AU - Lee,Fa-Yauh, AU - Lee,Shou-Dong, PY - 2007/4/4/pubmed PY - 2007/6/15/medline PY - 2007/4/4/entrez SP - 498 EP - 506 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 27 IS - 4 N2 - BACKGROUND: The models for end-stage liver disease (MELD) and serum sodium (SNa) are important prognostic markers in cirrhosis. A novel index, MELD to SNa ratio (MESO), was developed to amplify the opposing effect of MELD and SNa on outcome prediction. METHODS: A total of 213 cirrhotic patients undergoing hepatic venous pressure gradient (HVPG) measurement were retrospectively analyzed. RESULTS: The MESO index correlated with HVPG (r=0.258, P<0.001) and Child-Pugh score (rho=0.749, P<0.001). Using mortality as the end point, the area under receiver operating characteristic curve (AUC) was 0.860 for SNa, 0.795 for the MESO index and 0.789 for MELD (P values all >0.3) at 3 months. Among patients with Child-Pugh class A or B, the MESO index had a significantly higher AUC compared with MELD (0.80 vs. 0.766, P<0.001). A MESO index <1.6 identified 97% of patients who survived at 3 months and the predicted survival rate was 96.5%. In survival analysis, MESO index >1.6 independently predicted a higher mortality rate (relative risk: 3.32, P<0001) using the Cox model. CONCLUSIONS: The MESO index, which takes into account the predictive power of both MELD and SNa, is a useful prognostic predictor for both short- and long-term survival in cirrhotic patients. SN - 1478-3223 UR - https://www.unboundmedicine.com/medline/citation/17403190/Model_for_end_stage_liver_disease_score_to_serum_sodium_ratio_index_as_a_prognostic_predictor_and_its_correlation_with_portal_pressure_in_patients_with_liver_cirrhosis_ L2 - https://doi.org/10.1111/j.1478-3231.2007.01445.x DB - PRIME DP - Unbound Medicine ER -