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Influence of aqueous extract of Hibiscus sabdariffa L. petal on cadmium toxicity in rats.
Biol Trace Elem Res. 2007 Jan; 115(1):47-57.BT

Abstract

The effects of chronic exposure to cadmium (Cd) on some selected biochemical parameters, as well as the possible protective role of aqueous extracts of Hibiscus sabdariffa L petal were studied in 12-wk-old male Wistar albino rats. Exposure to Cd caused a significant increase in plasma Lalanine aminotransferases (ALT) only but with a corresponding decrease in liver L-alanine and L-aspartate aminotransferases (L-ALT, L-AST) when compared to the Cd-free control. Total superoxide dismutase activity was decreased in the liver, testis, and prostate of Cd-exposed rats, whereas malondialdehyde (MDA) concentrations were increased relative to the Cd-free control. The metal significantly increased prostatic acid phosphatase activity in the prostate, but decreased the body weight gain of the rats and organ/body weight ratio for prostate and testis compared to the Cd-free control. Pretreatment of rats with aqueous extract of H. sabdariffa resulted in significantly less hepatotoxicity than with Cd alone as measured by plasma ALT and liver ALT and AST activities. The extract also protected the rats against Cd-induced liver, prostate, and testis lipoperoxidation as evidenced by significantly reduced MDA values in these organs, as well as reduced prostatic acid phosphatase activity in the prostate, when compared to the Cd-only exposed rats. Also, when compared to the organ/body weight ratios obtained from rats exposed to Cd alone the prostate and testis were protected by the extract as shown by enhanced prostate/body weight and testis/body weight ratios of Cd- and extract-treated rats. These data suggest that H. sabdarrifa L might be protective in Cd toxicity.

Authors+Show Affiliations

Department of Biochemistry, Delta State University, P.M.B. 1, Abraka, Delta State, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17406073

Citation

Asagba, S O., et al. "Influence of Aqueous Extract of Hibiscus Sabdariffa L. Petal On Cadmium Toxicity in Rats." Biological Trace Element Research, vol. 115, no. 1, 2007, pp. 47-57.
Asagba SO, Adaikpoh MA, Kadiri H, et al. Influence of aqueous extract of Hibiscus sabdariffa L. petal on cadmium toxicity in rats. Biol Trace Elem Res. 2007;115(1):47-57.
Asagba, S. O., Adaikpoh, M. A., Kadiri, H., & Obi, F. O. (2007). Influence of aqueous extract of Hibiscus sabdariffa L. petal on cadmium toxicity in rats. Biological Trace Element Research, 115(1), 47-57.
Asagba SO, et al. Influence of Aqueous Extract of Hibiscus Sabdariffa L. Petal On Cadmium Toxicity in Rats. Biol Trace Elem Res. 2007;115(1):47-57. PubMed PMID: 17406073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of aqueous extract of Hibiscus sabdariffa L. petal on cadmium toxicity in rats. AU - Asagba,S O, AU - Adaikpoh,M A, AU - Kadiri,H, AU - Obi,F O, PY - 1999/11/30/received PY - 1999/11/30/revised PY - 1999/11/30/accepted PY - 2007/4/5/pubmed PY - 2007/9/22/medline PY - 2007/4/5/entrez SP - 47 EP - 57 JF - Biological trace element research JO - Biol Trace Elem Res VL - 115 IS - 1 N2 - The effects of chronic exposure to cadmium (Cd) on some selected biochemical parameters, as well as the possible protective role of aqueous extracts of Hibiscus sabdariffa L petal were studied in 12-wk-old male Wistar albino rats. Exposure to Cd caused a significant increase in plasma Lalanine aminotransferases (ALT) only but with a corresponding decrease in liver L-alanine and L-aspartate aminotransferases (L-ALT, L-AST) when compared to the Cd-free control. Total superoxide dismutase activity was decreased in the liver, testis, and prostate of Cd-exposed rats, whereas malondialdehyde (MDA) concentrations were increased relative to the Cd-free control. The metal significantly increased prostatic acid phosphatase activity in the prostate, but decreased the body weight gain of the rats and organ/body weight ratio for prostate and testis compared to the Cd-free control. Pretreatment of rats with aqueous extract of H. sabdariffa resulted in significantly less hepatotoxicity than with Cd alone as measured by plasma ALT and liver ALT and AST activities. The extract also protected the rats against Cd-induced liver, prostate, and testis lipoperoxidation as evidenced by significantly reduced MDA values in these organs, as well as reduced prostatic acid phosphatase activity in the prostate, when compared to the Cd-only exposed rats. Also, when compared to the organ/body weight ratios obtained from rats exposed to Cd alone the prostate and testis were protected by the extract as shown by enhanced prostate/body weight and testis/body weight ratios of Cd- and extract-treated rats. These data suggest that H. sabdarrifa L might be protective in Cd toxicity. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/17406073/Influence_of_aqueous_extract_of_Hibiscus_sabdariffa_L__petal_on_cadmium_toxicity_in_rats_ L2 - https://dx.doi.org/10.1385/BTER:115:1:47 DB - PRIME DP - Unbound Medicine ER -