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[Steatosis and non-alcoholic steatohepatitis in patients with chronic hepatitis due to hepatitis C virus infection].
Arq Gastroenterol 2006 Oct-Dec; 43(4):265-8AG

Abstract

BACKGROUND

[corrected] Hepatic steatosis is a common finding in patients with hepatitis C, mainly virus C genotype 3. Steatosis in these cases might be associated with antiviral treatment response and with prognosis of chronic hepatitis.

AIMS

To determine the presence of steatosis and non-alcoholic steatohepatitis in chronic hepatitis C and its correlation with genotype and hepatic fibrosis.

PATIENTS AND METHODS

One hundred and twenty patients with chronic hepatitis C were retrospectively evaluated; genotype was done in 102 patients. All specimens were stained with hematoxylin-eosin, picrosirius and perls. Staging of hepatitis C was scored by Brazilian Classification and the diagnosis of non-alcoholic steatohepatitis by the American Association for the Study of Liver Diseases criteria

RESULTS

Steatosis was found in 65 of 120 cases (54.2%); it was mild in 37/65 (56.9%), moderate in 12/65 (18.5%) and severe in 10/65 (15.4%). In relation to fibrosis, 80 of 120 patients had mild fibrosis F0-F2 (66.6%) and 40 (33.3%) had more advanced fibrosis (F3 or F4). Steatosis was associated with genotype 3 (76.7%) in comparison with other genotypes (49,0%). There were no relationship between steatosis and advanced fibrosis F3/F4 (52,5%) or mild fibrosis (54,4%). Non-alcoholic steatohepatitis was diagnosed in 8/120 cases (6.7%) and was significantly associated with hepatitis C virus genotype 3 and with advanced fibrosis (F3 and F4)

CONCLUSIONS

The presence of steatosis and non-alcoholic steatohepatitis in chronic hepatitis C are associated to genotype 3; moreover non-alcoholic steatohepatitis was correlated with more advanced fibrosis.

Authors+Show Affiliations

Serviço de Gastroenterologia Clinica e Cirúrgica, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS. g.coral@terra.com.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

por

PubMed ID

17406752

Citation

Coral, Gabriela, et al. "[Steatosis and Non-alcoholic Steatohepatitis in Patients With Chronic Hepatitis Due to Hepatitis C Virus Infection]." Arquivos De Gastroenterologia, vol. 43, no. 4, 2006, pp. 265-8.
Coral G, de Mattos AA, de Mattos AZ, et al. [Steatosis and non-alcoholic steatohepatitis in patients with chronic hepatitis due to hepatitis C virus infection]. Arq Gastroenterol. 2006;43(4):265-8.
Coral, G., de Mattos, A. A., de Mattos, A. Z., & dos Santos, D. E. (2006). [Steatosis and non-alcoholic steatohepatitis in patients with chronic hepatitis due to hepatitis C virus infection]. Arquivos De Gastroenterologia, 43(4), pp. 265-8.
Coral G, et al. [Steatosis and Non-alcoholic Steatohepatitis in Patients With Chronic Hepatitis Due to Hepatitis C Virus Infection]. Arq Gastroenterol. 2006;43(4):265-8. PubMed PMID: 17406752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Steatosis and non-alcoholic steatohepatitis in patients with chronic hepatitis due to hepatitis C virus infection]. AU - Coral,Gabriela, AU - de Mattos,Angelo Alves, AU - de Mattos,Angelo Zambam, AU - dos Santos,Diogo Edele, PY - 2005/11/29/received PY - 2006/06/05/accepted PY - 2007/4/5/pubmed PY - 2007/12/12/medline PY - 2007/4/5/entrez SP - 265 EP - 8 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 43 IS - 4 N2 - BACKGROUND: [corrected] Hepatic steatosis is a common finding in patients with hepatitis C, mainly virus C genotype 3. Steatosis in these cases might be associated with antiviral treatment response and with prognosis of chronic hepatitis. AIMS: To determine the presence of steatosis and non-alcoholic steatohepatitis in chronic hepatitis C and its correlation with genotype and hepatic fibrosis. PATIENTS AND METHODS: One hundred and twenty patients with chronic hepatitis C were retrospectively evaluated; genotype was done in 102 patients. All specimens were stained with hematoxylin-eosin, picrosirius and perls. Staging of hepatitis C was scored by Brazilian Classification and the diagnosis of non-alcoholic steatohepatitis by the American Association for the Study of Liver Diseases criteria RESULTS: Steatosis was found in 65 of 120 cases (54.2%); it was mild in 37/65 (56.9%), moderate in 12/65 (18.5%) and severe in 10/65 (15.4%). In relation to fibrosis, 80 of 120 patients had mild fibrosis F0-F2 (66.6%) and 40 (33.3%) had more advanced fibrosis (F3 or F4). Steatosis was associated with genotype 3 (76.7%) in comparison with other genotypes (49,0%). There were no relationship between steatosis and advanced fibrosis F3/F4 (52,5%) or mild fibrosis (54,4%). Non-alcoholic steatohepatitis was diagnosed in 8/120 cases (6.7%) and was significantly associated with hepatitis C virus genotype 3 and with advanced fibrosis (F3 and F4) CONCLUSIONS: The presence of steatosis and non-alcoholic steatohepatitis in chronic hepatitis C are associated to genotype 3; moreover non-alcoholic steatohepatitis was correlated with more advanced fibrosis. SN - 0004-2803 UR - https://www.unboundmedicine.com/medline/citation/17406752/[Steatosis_and_non_alcoholic_steatohepatitis_in_patients_with_chronic_hepatitis_due_to_hepatitis_C_virus_infection]_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000400004&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -