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Estrogen metabolism modulates bone density in men.
Calcif Tissue Int. 2007 Apr; 80(4):227-32.CT

Abstract

Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 +/- 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16alpha-hydroxyestrone (16alphaOHE(1)) and estriol (E(3)), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16alphaOHE(1)had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2-hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16alphaOHE(1), FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16alphaOHE(1) and E(3) levels are associated with high BMD at the proximal femur, and 16alphaOHE(1) appears to be a major determinant of BMD among the metabolites evaluated.

Authors+Show Affiliations

Division of Bone and Mineral Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. nnapoli@im.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17406768

Citation

Napoli, N, et al. "Estrogen Metabolism Modulates Bone Density in Men." Calcified Tissue International, vol. 80, no. 4, 2007, pp. 227-32.
Napoli N, Faccio R, Shrestha V, et al. Estrogen metabolism modulates bone density in men. Calcif Tissue Int. 2007;80(4):227-32.
Napoli, N., Faccio, R., Shrestha, V., Bucchieri, S., Rini, G. B., & Armamento-Villareal, R. (2007). Estrogen metabolism modulates bone density in men. Calcified Tissue International, 80(4), 227-32.
Napoli N, et al. Estrogen Metabolism Modulates Bone Density in Men. Calcif Tissue Int. 2007;80(4):227-32. PubMed PMID: 17406768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen metabolism modulates bone density in men. AU - Napoli,N, AU - Faccio,R, AU - Shrestha,V, AU - Bucchieri,S, AU - Rini,G Battista, AU - Armamento-Villareal,R, Y1 - 2007/04/04/ PY - 2006/06/26/received PY - 2007/01/09/accepted PY - 2007/4/5/pubmed PY - 2007/9/27/medline PY - 2007/4/5/entrez SP - 227 EP - 32 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 80 IS - 4 N2 - Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 +/- 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16alpha-hydroxyestrone (16alphaOHE(1)) and estriol (E(3)), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16alphaOHE(1)had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2-hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16alphaOHE(1), FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16alphaOHE(1) and E(3) levels are associated with high BMD at the proximal femur, and 16alphaOHE(1) appears to be a major determinant of BMD among the metabolites evaluated. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/17406768/Estrogen_metabolism_modulates_bone_density_in_men_ L2 - https://dx.doi.org/10.1007/s00223-007-9014-4 DB - PRIME DP - Unbound Medicine ER -