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Progressive exercise for anabolism in kidney disease (PEAK): a randomized, controlled trial of resistance training during hemodialysis.
J Am Soc Nephrol. 2007 May; 18(5):1594-601.JA

Abstract

Skeletal muscle wasting is common and insidious in patients who receive maintenance hemodialysis treatment for the management of ESRD. The objective of this study was to determine whether 12 wk of high-intensity, progressive resistance training (PRT) administered during routine hemodialysis treatment could improve skeletal muscle quantity and quality versus usual care. Forty-nine patients (62.6 +/- 14.2 yr; 0.3 to 16.7 yr on dialysis) were recruited from the outpatient hemodialysis unit of the St. George Public Hospital (Sydney, Australia). Patients were randomized to PRT + usual care (n = 24) or usual care control only (n = 25). The PRT group performed two sets of 10 exercises at a high intensity (15 to 17/20 on the Borg Scale) using free weights, three times per week for 12 wk during routine hemodialysis treatment. Primary outcomes included thigh muscle quantity (cross-sectional area [CSA]) and quality (intramuscular lipid content via attenuation) evaluated by computed tomography scan. Secondary outcomes included muscle strength, exercise capacity, body circumference measures, proinflammatory cytokine C-reactive protein, and quality of life. There was no statistically significant difference in muscle CSA change between groups. However, there were statistically significant improvements in muscle attenuation, muscle strength, mid-thigh and mid-arm circumference, body weight, and C-reactive protein in the PRT group relative to the nonexercising control group. These findings suggest that patients with ESRD can improve skeletal muscle quality and derive other health-related adaptations solely by engaging in a 12-wk high-intensity PRT regimen during routine hemodialysis treatment sessions. Longer training durations or more sensitive analysis techniques may be required to document alterations in muscle CSA.

Authors+Show Affiliations

School of Exercise and Sport Science and Faculty of Medicine, University of Sydney, Australia. b.cheema@massey.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17409306

Citation

Cheema, Bobby, et al. "Progressive Exercise for Anabolism in Kidney Disease (PEAK): a Randomized, Controlled Trial of Resistance Training During Hemodialysis." Journal of the American Society of Nephrology : JASN, vol. 18, no. 5, 2007, pp. 1594-601.
Cheema B, Abas H, Smith B, et al. Progressive exercise for anabolism in kidney disease (PEAK): a randomized, controlled trial of resistance training during hemodialysis. J Am Soc Nephrol. 2007;18(5):1594-601.
Cheema, B., Abas, H., Smith, B., O'Sullivan, A., Chan, M., Patwardhan, A., Kelly, J., Gillin, A., Pang, G., Lloyd, B., & Singh, M. F. (2007). Progressive exercise for anabolism in kidney disease (PEAK): a randomized, controlled trial of resistance training during hemodialysis. Journal of the American Society of Nephrology : JASN, 18(5), 1594-601.
Cheema B, et al. Progressive Exercise for Anabolism in Kidney Disease (PEAK): a Randomized, Controlled Trial of Resistance Training During Hemodialysis. J Am Soc Nephrol. 2007;18(5):1594-601. PubMed PMID: 17409306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive exercise for anabolism in kidney disease (PEAK): a randomized, controlled trial of resistance training during hemodialysis. AU - Cheema,Bobby, AU - Abas,Haifa, AU - Smith,Benjamin, AU - O'Sullivan,Anthony, AU - Chan,Maria, AU - Patwardhan,Aditi, AU - Kelly,John, AU - Gillin,Adrian, AU - Pang,Glen, AU - Lloyd,Brad, AU - Singh,Maria Fiatarone, Y1 - 2007/04/04/ PY - 2007/4/6/pubmed PY - 2007/8/8/medline PY - 2007/4/6/entrez SP - 1594 EP - 601 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 18 IS - 5 N2 - Skeletal muscle wasting is common and insidious in patients who receive maintenance hemodialysis treatment for the management of ESRD. The objective of this study was to determine whether 12 wk of high-intensity, progressive resistance training (PRT) administered during routine hemodialysis treatment could improve skeletal muscle quantity and quality versus usual care. Forty-nine patients (62.6 +/- 14.2 yr; 0.3 to 16.7 yr on dialysis) were recruited from the outpatient hemodialysis unit of the St. George Public Hospital (Sydney, Australia). Patients were randomized to PRT + usual care (n = 24) or usual care control only (n = 25). The PRT group performed two sets of 10 exercises at a high intensity (15 to 17/20 on the Borg Scale) using free weights, three times per week for 12 wk during routine hemodialysis treatment. Primary outcomes included thigh muscle quantity (cross-sectional area [CSA]) and quality (intramuscular lipid content via attenuation) evaluated by computed tomography scan. Secondary outcomes included muscle strength, exercise capacity, body circumference measures, proinflammatory cytokine C-reactive protein, and quality of life. There was no statistically significant difference in muscle CSA change between groups. However, there were statistically significant improvements in muscle attenuation, muscle strength, mid-thigh and mid-arm circumference, body weight, and C-reactive protein in the PRT group relative to the nonexercising control group. These findings suggest that patients with ESRD can improve skeletal muscle quality and derive other health-related adaptations solely by engaging in a 12-wk high-intensity PRT regimen during routine hemodialysis treatment sessions. Longer training durations or more sensitive analysis techniques may be required to document alterations in muscle CSA. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/17409306/Progressive_exercise_for_anabolism_in_kidney_disease__PEAK_:_a_randomized_controlled_trial_of_resistance_training_during_hemodialysis_ L2 - https://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=17409306 DB - PRIME DP - Unbound Medicine ER -