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Depressive symptoms, major depressive episode and cognition in the elderly: the three-city study.
Neuroepidemiology. 2007; 28(2):101-8.N

Abstract

OBJECTIVES

The relationship between depression and dementia in the elderly has been extensively studied but the tools used to define depressed subjects are heterogeneous between studies. The objective of this study was to examine the relationship between depression and cognitive performances by using multiple measures of depressive state.

METHODS

A sample of 7,869 nondemented community-dwelling persons aged >or=65 years participated in the study. Depressive symptoms were evaluated by the Center for Epidemiological Study Depression Scale and the Mini-International Neuropsychiatric Interview was used to assess history of major depressive episodes (MDE). Cognitive function was evaluated by several tests including the Mini-Mental State Examination (MMSE), Trail Making Test, Isaacs Set Test and Benton Visual Retention Test.

RESULTS

When studied in separate models, depressive symptoms were significantly related to lower cognitive performances for all neuropsychological tests after adjusting for potential confounders (p<0.0001), whereas subjects with current MDE had significantly lower performances in MMSE and Isaacs Set Test. When studied concomitantly, only high levels of depressive symptoms were related to lower cognitive performance, whereas existence of MDE (past or current) was no longer associated with cognitive performances.

CONCLUSIONS

These data suggest that once current depressive symptoms are taken into account, major depression (past or current) is not associated with lower cognitive performances in a community-based sample of elderly people aged >or=65 years.

Authors+Show Affiliations

INSERM U708, Université Pierre et Marie Curie-Paris 6, Paris, France. ophelia.godin@chups.jussieu.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17409771

Citation

Godin, Ophélia, et al. "Depressive Symptoms, Major Depressive Episode and Cognition in the Elderly: the Three-city Study." Neuroepidemiology, vol. 28, no. 2, 2007, pp. 101-8.
Godin O, Dufouil C, Ritchie K, et al. Depressive symptoms, major depressive episode and cognition in the elderly: the three-city study. Neuroepidemiology. 2007;28(2):101-8.
Godin, O., Dufouil, C., Ritchie, K., Dartigues, J. F., Tzourio, C., Pérès, K., Artero, S., & Alpérovitch, A. (2007). Depressive symptoms, major depressive episode and cognition in the elderly: the three-city study. Neuroepidemiology, 28(2), 101-8.
Godin O, et al. Depressive Symptoms, Major Depressive Episode and Cognition in the Elderly: the Three-city Study. Neuroepidemiology. 2007;28(2):101-8. PubMed PMID: 17409771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms, major depressive episode and cognition in the elderly: the three-city study. AU - Godin,Ophélia, AU - Dufouil,Carole, AU - Ritchie,Karen, AU - Dartigues,Jean-François, AU - Tzourio,Christophe, AU - Pérès,Karine, AU - Artero,Sylvaine, AU - Alpérovitch,Annick, Y1 - 2007/04/04/ PY - 2007/4/6/pubmed PY - 2007/5/23/medline PY - 2007/4/6/entrez SP - 101 EP - 8 JF - Neuroepidemiology JO - Neuroepidemiology VL - 28 IS - 2 N2 - OBJECTIVES: The relationship between depression and dementia in the elderly has been extensively studied but the tools used to define depressed subjects are heterogeneous between studies. The objective of this study was to examine the relationship between depression and cognitive performances by using multiple measures of depressive state. METHODS: A sample of 7,869 nondemented community-dwelling persons aged >or=65 years participated in the study. Depressive symptoms were evaluated by the Center for Epidemiological Study Depression Scale and the Mini-International Neuropsychiatric Interview was used to assess history of major depressive episodes (MDE). Cognitive function was evaluated by several tests including the Mini-Mental State Examination (MMSE), Trail Making Test, Isaacs Set Test and Benton Visual Retention Test. RESULTS: When studied in separate models, depressive symptoms were significantly related to lower cognitive performances for all neuropsychological tests after adjusting for potential confounders (p<0.0001), whereas subjects with current MDE had significantly lower performances in MMSE and Isaacs Set Test. When studied concomitantly, only high levels of depressive symptoms were related to lower cognitive performance, whereas existence of MDE (past or current) was no longer associated with cognitive performances. CONCLUSIONS: These data suggest that once current depressive symptoms are taken into account, major depression (past or current) is not associated with lower cognitive performances in a community-based sample of elderly people aged >or=65 years. SN - 0251-5350 UR - https://www.unboundmedicine.com/medline/citation/17409771/Depressive_symptoms_major_depressive_episode_and_cognition_in_the_elderly:_the_three_city_study_ L2 - https://www.karger.com?DOI=10.1159/000101508 DB - PRIME DP - Unbound Medicine ER -