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[Failure to thrive and psychomotor regression revealing vitamin B12 deficiency in 3 infants].
Arch Pediatr. 2007 May; 14(5):467-71.AP

Abstract

The newborn's vitamin B12 storage exclusively comes from placenta transfer, later from animal food. We relate 3 observations of infants (3-11-13 months) with failure to thrive, anorexia, vomiting and for the two olders refusal of weaning, associated with psychomotricity regression and hypotony. Blood cell count showed a macrocytosis without anemia (case 2-3) and a severe microcytic anemia for the first case caused by a mild alpha-thalassemia, with megaloblastic bone marrow. Vitamin B12 levels were very low associated with increased methylmalonic acid and homocysteine serum levels which confirm the diagnostic . Cerebral imaging showed diffuse cortical atrophy. Cobalamin deficiency was caused by strict vegetarian diets mothers of breastfed infants (cases 2-3) and for younger by mother's unrecognized pernicious anemia. 3 mothers had no anemia and normal B12 's levels at diagnosis. Vitamin B12 supply lead to a rapid clinical and hematologic improvement. In two cases, neurologic recovery was incomplete. About one hundred case of B12 deficiency 's infant are reported, 2/3 are breast-fed by vegetarian mothers, and 1/4 have mothers with pernicious anemia. The failure to thrive is due to anorexia, refusal of weaning and partial villous atrophy. Neurologic manifestations are secondary to cerebral disorders, sometimes revealed by an exposure to anesthetic nitrous oxyd. The macrocytic anemia is inconstant. The etiologic research of developmental delay in an infant may include vitamin B12's deficiency, even if there is no haematologic signs, especially if breast-fedding 's mothers is vegetarian.

Authors+Show Affiliations

Service de Pédiatrie,Centre Hospitalier du Pays d'Aix, avenue des Tamaris, 13616 Aix-en-Provence, France. cmathey@ch-aix.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

17412572

Citation

Mathey, C, et al. "[Failure to Thrive and Psychomotor Regression Revealing Vitamin B12 Deficiency in 3 Infants]." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 14, no. 5, 2007, pp. 467-71.
Mathey C, Di Marco JN, Poujol A, et al. [Failure to thrive and psychomotor regression revealing vitamin B12 deficiency in 3 infants]. Arch Pediatr. 2007;14(5):467-71.
Mathey, C., Di Marco, J. N., Poujol, A., Cournelle, M. A., Brevaut, V., Livet, M. O., Chabrol, B., & Michel, G. (2007). [Failure to thrive and psychomotor regression revealing vitamin B12 deficiency in 3 infants]. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 14(5), 467-71.
Mathey C, et al. [Failure to Thrive and Psychomotor Regression Revealing Vitamin B12 Deficiency in 3 Infants]. Arch Pediatr. 2007;14(5):467-71. PubMed PMID: 17412572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Failure to thrive and psychomotor regression revealing vitamin B12 deficiency in 3 infants]. AU - Mathey,C, AU - Di Marco,J-N, AU - Poujol,A, AU - Cournelle,M-A, AU - Brevaut,V, AU - Livet,M-O, AU - Chabrol,B, AU - Michel,G, Y1 - 2007/04/06/ PY - 2006/01/20/received PY - 2007/01/22/accepted PY - 2007/4/7/pubmed PY - 2007/8/1/medline PY - 2007/4/7/entrez SP - 467 EP - 71 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 14 IS - 5 N2 - The newborn's vitamin B12 storage exclusively comes from placenta transfer, later from animal food. We relate 3 observations of infants (3-11-13 months) with failure to thrive, anorexia, vomiting and for the two olders refusal of weaning, associated with psychomotricity regression and hypotony. Blood cell count showed a macrocytosis without anemia (case 2-3) and a severe microcytic anemia for the first case caused by a mild alpha-thalassemia, with megaloblastic bone marrow. Vitamin B12 levels were very low associated with increased methylmalonic acid and homocysteine serum levels which confirm the diagnostic . Cerebral imaging showed diffuse cortical atrophy. Cobalamin deficiency was caused by strict vegetarian diets mothers of breastfed infants (cases 2-3) and for younger by mother's unrecognized pernicious anemia. 3 mothers had no anemia and normal B12 's levels at diagnosis. Vitamin B12 supply lead to a rapid clinical and hematologic improvement. In two cases, neurologic recovery was incomplete. About one hundred case of B12 deficiency 's infant are reported, 2/3 are breast-fed by vegetarian mothers, and 1/4 have mothers with pernicious anemia. The failure to thrive is due to anorexia, refusal of weaning and partial villous atrophy. Neurologic manifestations are secondary to cerebral disorders, sometimes revealed by an exposure to anesthetic nitrous oxyd. The macrocytic anemia is inconstant. The etiologic research of developmental delay in an infant may include vitamin B12's deficiency, even if there is no haematologic signs, especially if breast-fedding 's mothers is vegetarian. SN - 0929-693X UR - https://www.unboundmedicine.com/medline/citation/17412572/[Failure_to_thrive_and_psychomotor_regression_revealing_vitamin_B12_deficiency_in_3_infants]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-693X(07)00066-8 DB - PRIME DP - Unbound Medicine ER -