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Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma.
Respir Med. 2007 Aug; 101(8):1770-8.RM

Abstract

BACKGROUND

Previous research has shown that diet can modify the bronchoconstrictor response to exercise in asthmatic subjects.

OBJECTIVE

Determine the effect of ascorbic acid supplementation on pulmonary function and several urinary markers of airway inflammation in asthmatic subjects with exercise-induced bronchoconstriction (EIB).

METHODS

Eight asthmatic subjects with documented EIB participated in a randomized, placebo controlled double-blind crossover trial. Subjects entered the study on their usual diet and were placed on either 2 weeks of ascorbic acid supplementation (1500 mg/day) or placebo, followed by a 1-week washout period, before crossing over to the alternative diet. Pre- and post-exercise pulmonary function, asthma symptom scores, fraction of exhaled nitric oxide (FENO), and urinary leukotriene (LT) C4-E4 and 9alpha, 11beta-prostagladin (PG) F2] were assessed at the beginning of the trial (usual diet) and at the end of each treatment period.

RESULTS

The ascorbic acid diet significantly reduced (p < 0.05) the maximum fall in post-exercise FEV1 (-6.4 +/- 2.4%) compared to usual (-14.3 +/- 1.6%) and placebo diet (-12.9 +/- 2.4%). Asthma symptoms scores significantly improved (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Post-exercise FENO, LTC4-E4 and 9alpha, 11beta-PGF2 concentration was significantly lower (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet.

CONCLUSION

Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects.

Authors+Show Affiliations

Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, 1025 E. 7th St, HPER 112, Bloomington, IN 47401, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17412579

Citation

Tecklenburg, Sandra L., et al. "Ascorbic Acid Supplementation Attenuates Exercise-induced Bronchoconstriction in Patients With Asthma." Respiratory Medicine, vol. 101, no. 8, 2007, pp. 1770-8.
Tecklenburg SL, Mickleborough TD, Fly AD, et al. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med. 2007;101(8):1770-8.
Tecklenburg, S. L., Mickleborough, T. D., Fly, A. D., Bai, Y., & Stager, J. M. (2007). Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respiratory Medicine, 101(8), 1770-8.
Tecklenburg SL, et al. Ascorbic Acid Supplementation Attenuates Exercise-induced Bronchoconstriction in Patients With Asthma. Respir Med. 2007;101(8):1770-8. PubMed PMID: 17412579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. AU - Tecklenburg,Sandra L, AU - Mickleborough,Timothy D, AU - Fly,Alyce D, AU - Bai,Yeon, AU - Stager,Joel M, Y1 - 2007/04/05/ PY - 2006/12/08/received PY - 2007/02/08/revised PY - 2007/02/20/accepted PY - 2007/4/7/pubmed PY - 2007/12/6/medline PY - 2007/4/7/entrez SP - 1770 EP - 8 JF - Respiratory medicine JO - Respir Med VL - 101 IS - 8 N2 - BACKGROUND: Previous research has shown that diet can modify the bronchoconstrictor response to exercise in asthmatic subjects. OBJECTIVE: Determine the effect of ascorbic acid supplementation on pulmonary function and several urinary markers of airway inflammation in asthmatic subjects with exercise-induced bronchoconstriction (EIB). METHODS: Eight asthmatic subjects with documented EIB participated in a randomized, placebo controlled double-blind crossover trial. Subjects entered the study on their usual diet and were placed on either 2 weeks of ascorbic acid supplementation (1500 mg/day) or placebo, followed by a 1-week washout period, before crossing over to the alternative diet. Pre- and post-exercise pulmonary function, asthma symptom scores, fraction of exhaled nitric oxide (FENO), and urinary leukotriene (LT) C4-E4 and 9alpha, 11beta-prostagladin (PG) F2] were assessed at the beginning of the trial (usual diet) and at the end of each treatment period. RESULTS: The ascorbic acid diet significantly reduced (p < 0.05) the maximum fall in post-exercise FEV1 (-6.4 +/- 2.4%) compared to usual (-14.3 +/- 1.6%) and placebo diet (-12.9 +/- 2.4%). Asthma symptoms scores significantly improved (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Post-exercise FENO, LTC4-E4 and 9alpha, 11beta-PGF2 concentration was significantly lower (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. CONCLUSION: Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/17412579/Ascorbic_acid_supplementation_attenuates_exercise_induced_bronchoconstriction_in_patients_with_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(07)00088-1 DB - PRIME DP - Unbound Medicine ER -