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Role of aerobic fitness and aging on cerebral white matter integrity.

Abstract

Neuroimaging research suggests that cerebral white matter (WM) integrity, as reflected in fractional anisotropy (FA) via diffusion tensor imaging (DTI), is decreased in older adults, especially in the prefrontal regions of the brain. Behavioral investigations of cognitive functioning suggest that some aspects of cognition may be better preserved in older adults who possess higher levels of aerobic fitness. There are only a few studies, however, investigating potential mechanisms for the improvements in aerobic fitness. Our study suggests that greater aerobic fitness may be related to greater WM integrity in select brain regions.

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  • Authors+Show Affiliations

    ,

    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA. marks@email.unc.edu

    , , , , ,

    Source

    MeSH

    Adult
    Aerobiosis
    Aged
    Aging
    Anaerobic Threshold
    Anisotropy
    Body Mass Index
    Brain
    Diffusion Magnetic Resonance Imaging
    Female
    Humans
    Male
    Motor Activity
    Oxygen Consumption
    Physical Fitness
    Sex Characteristics

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17413020

    Citation

    Marks, Bonita L., et al. "Role of Aerobic Fitness and Aging On Cerebral White Matter Integrity." Annals of the New York Academy of Sciences, vol. 1097, 2007, pp. 171-4.
    Marks BL, Madden DJ, Bucur B, et al. Role of aerobic fitness and aging on cerebral white matter integrity. Ann N Y Acad Sci. 2007;1097:171-4.
    Marks, B. L., Madden, D. J., Bucur, B., Provenzale, J. M., White, L. E., Cabeza, R., & Huettel, S. A. (2007). Role of aerobic fitness and aging on cerebral white matter integrity. Annals of the New York Academy of Sciences, 1097, pp. 171-4.
    Marks BL, et al. Role of Aerobic Fitness and Aging On Cerebral White Matter Integrity. Ann N Y Acad Sci. 2007;1097:171-4. PubMed PMID: 17413020.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of aerobic fitness and aging on cerebral white matter integrity. AU - Marks,Bonita L, AU - Madden,David J, AU - Bucur,Barbara, AU - Provenzale,James M, AU - White,Leonard E, AU - Cabeza,Roberto, AU - Huettel,Scott A, PY - 2007/4/7/pubmed PY - 2007/4/26/medline PY - 2007/4/7/entrez SP - 171 EP - 4 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1097 N2 - Neuroimaging research suggests that cerebral white matter (WM) integrity, as reflected in fractional anisotropy (FA) via diffusion tensor imaging (DTI), is decreased in older adults, especially in the prefrontal regions of the brain. Behavioral investigations of cognitive functioning suggest that some aspects of cognition may be better preserved in older adults who possess higher levels of aerobic fitness. There are only a few studies, however, investigating potential mechanisms for the improvements in aerobic fitness. Our study suggests that greater aerobic fitness may be related to greater WM integrity in select brain regions. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/17413020/Role_of_aerobic_fitness_and_aging_on_cerebral_white_matter_integrity_ L2 - https://doi.org/10.1196/annals.1379.022 DB - PRIME DP - Unbound Medicine ER -