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Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake.
Am J Clin Nutr. 2007 Apr; 85(4):972-80.AJ

Abstract

BACKGROUND

Weight loss is associated with bone loss, but this has not been examined in overweight premenopausal women.

OBJECTIVE

The aim of this study was to assess whether overweight premenopausal women lose bone with moderate weight loss at recommended or higher than recommended calcium intakes.

DESIGN

Overweight premenopausal women [n = 44; x (+/-SD) age: 38 +/- 6.4 y; body mass index (BMI): 27.7 +/- 2.1 kg/m(2)] were randomly assigned to either a normal (1 g/d) or high (1.8 g/d) calcium intake during 6 mo of energy restriction [weight loss (WL) groups] or were recruited for weight maintenance at 1 g Ca/d intake. Regional bone mineral density and content were measured by dual-energy X-ray absorptiometry, and markers of bone turnover were measured before and after weight loss. True fractional calcium absorption (TFCA) was measured at baseline and during caloric restriction by using a dual-stable calcium isotope method.

RESULTS

The WL groups lost 7.2 +/- 3.3% of initial body weight. No significant decrease in BMD or rise in bone turnover was observed with weight loss at normal or high calcium intake. The group that consumed high calcium showed a strong relation (r = 0.71) between increased femoral neck bone mineral density and increased serum 25-hydroxyvitamin D. No significant effect of weight loss on TFCA was observed, and the total calcium absorbed was adequate at 238 +/- 81 and 310 +/- 91 mg/d for the normal- and high-calcium WL groups, respectively.

CONCLUSION

Overweight premenopausal women do not lose bone during weight loss at the recommended calcium intake, which may be explained by sufficient amounts of absorbed calcium.

Authors+Show Affiliations

Rutgers University, New Brunswick, NJ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17413095

Citation

Riedt, Claudia S., et al. "Premenopausal Overweight Women Do Not Lose Bone During Moderate Weight Loss With Adequate or Higher Calcium Intake." The American Journal of Clinical Nutrition, vol. 85, no. 4, 2007, pp. 972-80.
Riedt CS, Schlussel Y, von Thun N, et al. Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake. Am J Clin Nutr. 2007;85(4):972-80.
Riedt, C. S., Schlussel, Y., von Thun, N., Ambia-Sobhan, H., Stahl, T., Field, M. P., Sherrell, R. M., & Shapses, S. A. (2007). Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake. The American Journal of Clinical Nutrition, 85(4), 972-80.
Riedt CS, et al. Premenopausal Overweight Women Do Not Lose Bone During Moderate Weight Loss With Adequate or Higher Calcium Intake. Am J Clin Nutr. 2007;85(4):972-80. PubMed PMID: 17413095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake. AU - Riedt,Claudia S, AU - Schlussel,Yvette, AU - von Thun,Nancy, AU - Ambia-Sobhan,Hasina, AU - Stahl,Theodore, AU - Field,M Paul, AU - Sherrell,Robert M, AU - Shapses,Sue A, PY - 2007/4/7/pubmed PY - 2007/5/16/medline PY - 2007/4/7/entrez SP - 972 EP - 80 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 85 IS - 4 N2 - BACKGROUND: Weight loss is associated with bone loss, but this has not been examined in overweight premenopausal women. OBJECTIVE: The aim of this study was to assess whether overweight premenopausal women lose bone with moderate weight loss at recommended or higher than recommended calcium intakes. DESIGN: Overweight premenopausal women [n = 44; x (+/-SD) age: 38 +/- 6.4 y; body mass index (BMI): 27.7 +/- 2.1 kg/m(2)] were randomly assigned to either a normal (1 g/d) or high (1.8 g/d) calcium intake during 6 mo of energy restriction [weight loss (WL) groups] or were recruited for weight maintenance at 1 g Ca/d intake. Regional bone mineral density and content were measured by dual-energy X-ray absorptiometry, and markers of bone turnover were measured before and after weight loss. True fractional calcium absorption (TFCA) was measured at baseline and during caloric restriction by using a dual-stable calcium isotope method. RESULTS: The WL groups lost 7.2 +/- 3.3% of initial body weight. No significant decrease in BMD or rise in bone turnover was observed with weight loss at normal or high calcium intake. The group that consumed high calcium showed a strong relation (r = 0.71) between increased femoral neck bone mineral density and increased serum 25-hydroxyvitamin D. No significant effect of weight loss on TFCA was observed, and the total calcium absorbed was adequate at 238 +/- 81 and 310 +/- 91 mg/d for the normal- and high-calcium WL groups, respectively. CONCLUSION: Overweight premenopausal women do not lose bone during weight loss at the recommended calcium intake, which may be explained by sufficient amounts of absorbed calcium. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17413095/Premenopausal_overweight_women_do_not_lose_bone_during_moderate_weight_loss_with_adequate_or_higher_calcium_intake_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/85.4.972 DB - PRIME DP - Unbound Medicine ER -