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Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial.

Abstract

OBJECTIVE

Long-term effects of soy-derived isoflavones on lipids remain uncertain, and few data are available on their effects on glycemic control. We examined the effects of isolated soy germ isoflavones on the changes in fasting glucose (FG) and lipids.

DESIGN

A double-blind, randomized, placebo-controlled trial was conducted in 203 postmenopausal Chinese women aged 48 to 62 years. They were randomly assigned to receive daily doses of 500 mg calcium, and 0 mg isoflavones (placebo, n=67), 40 mg isoflavones (n=68), and 80 mg isoflavones (n=68). Serum FG, triglycerides, high-density lipoprotein, low-density lipoprotein, total cholesterol, and lipoprotein cholesterol were measured at baseline and 1 year after treatment. The primary data analysis was performed on the 203 randomized women according to the intent-to-treat principle. The last value carried forward was used for any missing data at follow-up.

RESULTS

We observed moderate but significant favorable effects of soy isoflavones on the changes (P=0.012) and percentage of changes (P=0.031) in FG (analysis of variance). The 1-year mean (SD) differences of FG changes were -5.2 (-9.4 to -1.0) mg/dL (P=0.010) and -3.3 (-7.5 to 0.9) mg/dL (P=0.18) in the 40- and 80-mg isoflavone groups compared with the placebo group. We also noted a significant interaction between the treatment and baseline FG on the changes in FG (P=0.004). The isoflavone effects were much more significant in women with baseline FG 100 mg/dL or more than in those with FG less than 90 mg/dL. We observed little effect of soy isoflavones on changes in serum lipids among the treatment groups.

CONCLUSIONS

One-year of soy isoflavone supplementation might have a favorable effect on FG in women, but has no significant effect on serum lipids.

Links

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  • Authors+Show Affiliations

    ,

    Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong SAR. suzanneho@cuhk.edu.hk

    , ,

    Source

    MeSH

    Blood Glucose
    China
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Double-Blind Method
    Female
    Humans
    Isoflavones
    Middle Aged
    Osteoporosis, Postmenopausal
    Postmenopause
    Soybean Proteins
    Surveys and Questionnaires
    Treatment Outcome
    Triglycerides
    Women's Health

    Pub Type(s)

    Controlled Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17413839

    Citation

    Ho, Suzanne C., et al. "Soy Isoflavone Supplementation and Fasting Serum Glucose and Lipid Profile Among Postmenopausal Chinese Women: a Double-blind, Randomized, Placebo-controlled Trial." Menopause (New York, N.Y.), vol. 14, no. 5, 2007, pp. 905-12.
    Ho SC, Chen YM, Ho SS, et al. Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial. Menopause. 2007;14(5):905-12.
    Ho, S. C., Chen, Y. M., Ho, S. S., & Woo, J. L. (2007). Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial. Menopause (New York, N.Y.), 14(5), pp. 905-12.
    Ho SC, et al. Soy Isoflavone Supplementation and Fasting Serum Glucose and Lipid Profile Among Postmenopausal Chinese Women: a Double-blind, Randomized, Placebo-controlled Trial. Menopause. 2007;14(5):905-12. PubMed PMID: 17413839.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial. AU - Ho,Suzanne C, AU - Chen,Yu-ming, AU - Ho,Susan S S, AU - Woo,Jean L F, PY - 2007/4/7/pubmed PY - 2007/12/19/medline PY - 2007/4/7/entrez SP - 905 EP - 12 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 5 N2 - OBJECTIVE: Long-term effects of soy-derived isoflavones on lipids remain uncertain, and few data are available on their effects on glycemic control. We examined the effects of isolated soy germ isoflavones on the changes in fasting glucose (FG) and lipids. DESIGN: A double-blind, randomized, placebo-controlled trial was conducted in 203 postmenopausal Chinese women aged 48 to 62 years. They were randomly assigned to receive daily doses of 500 mg calcium, and 0 mg isoflavones (placebo, n=67), 40 mg isoflavones (n=68), and 80 mg isoflavones (n=68). Serum FG, triglycerides, high-density lipoprotein, low-density lipoprotein, total cholesterol, and lipoprotein cholesterol were measured at baseline and 1 year after treatment. The primary data analysis was performed on the 203 randomized women according to the intent-to-treat principle. The last value carried forward was used for any missing data at follow-up. RESULTS: We observed moderate but significant favorable effects of soy isoflavones on the changes (P=0.012) and percentage of changes (P=0.031) in FG (analysis of variance). The 1-year mean (SD) differences of FG changes were -5.2 (-9.4 to -1.0) mg/dL (P=0.010) and -3.3 (-7.5 to 0.9) mg/dL (P=0.18) in the 40- and 80-mg isoflavone groups compared with the placebo group. We also noted a significant interaction between the treatment and baseline FG on the changes in FG (P=0.004). The isoflavone effects were much more significant in women with baseline FG 100 mg/dL or more than in those with FG less than 90 mg/dL. We observed little effect of soy isoflavones on changes in serum lipids among the treatment groups. CONCLUSIONS: One-year of soy isoflavone supplementation might have a favorable effect on FG in women, but has no significant effect on serum lipids. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17413839/Soy_isoflavone_supplementation_and_fasting_serum_glucose_and_lipid_profile_among_postmenopausal_Chinese_women:_a_double_blind_randomized_placebo_controlled_trial_ L2 - http://Insights.ovid.com/pubmed?pmid=17413839 DB - PRIME DP - Unbound Medicine ER -