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Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease.
Pediatr Res. 2007 May; 61(5 Pt 1):607-13.PR

Abstract

Previous studies of children with sickle cell disease (SCD) reported poor growth and delayed maturation. However, the prevalence, magnitude, and correlates of suboptimal growth remain poorly understood. A prospective longitudinal study was undertaken to determine the effects of disease severity and nutritional status on growth, an indicator of childhood well-being. Children, birth to 18 y of age, with SCD-SS were evaluated annually for 4 y. Growth, nutritional status, skeletal and sexual maturation, disease severity, dietary intake, and maternal education were assessed. In this sample of 148 children (78 females), growth in height, weight, or body mass index declined in 84% of subjects; 38% fell below the 5th percentile in one or more measures. Puberty was delayed 1 to 2 y, and median age at menarche was 13.2 y. Skeletal age was delayed by 0.7 +/- 1.4 y overall and by 1.3 +/- 1.5 y in children 10 to 15 y old. Height status declined over time and was positively associated with advancing puberty and hematological measures in girls, and nutritional status in girls and boys. Growth failure and maturational delay remain significant chronic problems in children with SCD-SS and are related to potentially modifiable factors such as nutritional status.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. zemel@email.chop.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17413865

Citation

Zemel, Babette S., et al. "Effects of Delayed Pubertal Development, Nutritional Status, and Disease Severity On Longitudinal Patterns of Growth Failure in Children With Sickle Cell Disease." Pediatric Research, vol. 61, no. 5 Pt 1, 2007, pp. 607-13.
Zemel BS, Kawchak DA, Ohene-Frempong K, et al. Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease. Pediatr Res. 2007;61(5 Pt 1):607-13.
Zemel, B. S., Kawchak, D. A., Ohene-Frempong, K., Schall, J. I., & Stallings, V. A. (2007). Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease. Pediatric Research, 61(5 Pt 1), 607-13.
Zemel BS, et al. Effects of Delayed Pubertal Development, Nutritional Status, and Disease Severity On Longitudinal Patterns of Growth Failure in Children With Sickle Cell Disease. Pediatr Res. 2007;61(5 Pt 1):607-13. PubMed PMID: 17413865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease. AU - Zemel,Babette S, AU - Kawchak,Deborah A, AU - Ohene-Frempong,Kwaku, AU - Schall,Joan I, AU - Stallings,Virginia A, PY - 2007/4/7/pubmed PY - 2007/7/17/medline PY - 2007/4/7/entrez SP - 607 EP - 13 JF - Pediatric research JO - Pediatr Res VL - 61 IS - 5 Pt 1 N2 - Previous studies of children with sickle cell disease (SCD) reported poor growth and delayed maturation. However, the prevalence, magnitude, and correlates of suboptimal growth remain poorly understood. A prospective longitudinal study was undertaken to determine the effects of disease severity and nutritional status on growth, an indicator of childhood well-being. Children, birth to 18 y of age, with SCD-SS were evaluated annually for 4 y. Growth, nutritional status, skeletal and sexual maturation, disease severity, dietary intake, and maternal education were assessed. In this sample of 148 children (78 females), growth in height, weight, or body mass index declined in 84% of subjects; 38% fell below the 5th percentile in one or more measures. Puberty was delayed 1 to 2 y, and median age at menarche was 13.2 y. Skeletal age was delayed by 0.7 +/- 1.4 y overall and by 1.3 +/- 1.5 y in children 10 to 15 y old. Height status declined over time and was positively associated with advancing puberty and hematological measures in girls, and nutritional status in girls and boys. Growth failure and maturational delay remain significant chronic problems in children with SCD-SS and are related to potentially modifiable factors such as nutritional status. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/17413865/Effects_of_delayed_pubertal_development_nutritional_status_and_disease_severity_on_longitudinal_patterns_of_growth_failure_in_children_with_sickle_cell_disease_ L2 - https://doi.org/10.1203/pdr.0b013e318045bdca DB - PRIME DP - Unbound Medicine ER -