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Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease.

Abstract

BACKGROUND

The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing due to its prevalence in obesity, diabetes, and insulin-resistance syndrome. The best treatment protocol for NAFLD has not been determined. However, there is evidence that exercise and nutritional intervention can improve and prevent it. The aim of the present study was to evaluate the dietary and metabolic profiles of obese adolescents with NAFLD who participated in a multidisciplinary program.

PATIENTS AND METHODS

We studied 43 adolescents ages 15 to 19 years (17.18 +/- 1.66 years) with a body mass index (BMI) > or = 30, consisting of 30 patients without NAFLD (BMI = 35.80 +/- 3.44 kg/m2) and 13 with NAFLD (BMI = 33.47 +/- 2.34 kg/m2). The NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic aminotransferase levels, and lipid profiles. Insulin resistance was measured by homeostasis model assessment insulin-resistance index (HOMA-IR). The analyses of baseline and postintervention food intake were made by a 3-day inquiry.

RESULTS

At baseline conditions, the patients with NAFLD showed significant differences in body mass, BMI, and visceral and subcutaneous fat. Glucose and visceral and subcutaneous fat presented a significant reduction after treatment in patients with NAFLD. Analyzing the food intake, at baseline we observed a positive correlation between the visceral obesity and lipid consumption only in patients with NAFLD. We also observed significant decrease in energy and cholesterol consumption in patients with NAFLD after the multidisciplinary therapy.

CONCLUSIONS

The intervention promoted a decrease in the prevalence of NAFLD, a significant decrease in visceral obesity, and improved HOMA-IR, glycemia, and serum lipid levels that are risk factors for NAFLD. In summary, the multidisciplinary program is essential in the treatment and prevention of NAFLD.

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  • Authors+Show Affiliations

    ,

    Federal University of São Paulo, Escola Paulista de Medicina UNIFESP-EPM, São Paulo, Brazil.

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    Source

    MeSH

    Adolescent
    Adult
    Body Fat Distribution
    Dietary Fats
    Energy Intake
    Fatty Liver
    Female
    Humans
    Insulin Resistance
    Male
    Nutritional Status
    Obesity
    Risk Factors
    Ultrasonography

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17414142

    Citation

    de Piano, Aline, et al. "Metabolic and Nutritional Profile of Obese Adolescents With Nonalcoholic Fatty Liver Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 44, no. 4, 2007, pp. 446-52.
    de Piano A, Prado WL, Caranti DA, et al. Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2007;44(4):446-52.
    de Piano, A., Prado, W. L., Caranti, D. A., Siqueira, K. O., Stella, S. G., Lofrano, M., ... Dâmaso, A. R. (2007). Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease. Journal of Pediatric Gastroenterology and Nutrition, 44(4), pp. 446-52.
    de Piano A, et al. Metabolic and Nutritional Profile of Obese Adolescents With Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2007;44(4):446-52. PubMed PMID: 17414142.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease. AU - de Piano,Aline, AU - Prado,Wagner L, AU - Caranti,Danielle A, AU - Siqueira,Kãli O, AU - Stella,Sérgio G, AU - Lofrano,Mara, AU - Tock,Lian, AU - Cristofalo,Dejaldo M J, AU - Lederman,Henrique, AU - Tufik,Sérgio, AU - de Mello,Marco Túlio, AU - Dâmaso,Ana R, PY - 2007/4/7/pubmed PY - 2007/4/25/medline PY - 2007/4/7/entrez SP - 446 EP - 52 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 44 IS - 4 N2 - BACKGROUND: The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing due to its prevalence in obesity, diabetes, and insulin-resistance syndrome. The best treatment protocol for NAFLD has not been determined. However, there is evidence that exercise and nutritional intervention can improve and prevent it. The aim of the present study was to evaluate the dietary and metabolic profiles of obese adolescents with NAFLD who participated in a multidisciplinary program. PATIENTS AND METHODS: We studied 43 adolescents ages 15 to 19 years (17.18 +/- 1.66 years) with a body mass index (BMI) > or = 30, consisting of 30 patients without NAFLD (BMI = 35.80 +/- 3.44 kg/m2) and 13 with NAFLD (BMI = 33.47 +/- 2.34 kg/m2). The NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic aminotransferase levels, and lipid profiles. Insulin resistance was measured by homeostasis model assessment insulin-resistance index (HOMA-IR). The analyses of baseline and postintervention food intake were made by a 3-day inquiry. RESULTS: At baseline conditions, the patients with NAFLD showed significant differences in body mass, BMI, and visceral and subcutaneous fat. Glucose and visceral and subcutaneous fat presented a significant reduction after treatment in patients with NAFLD. Analyzing the food intake, at baseline we observed a positive correlation between the visceral obesity and lipid consumption only in patients with NAFLD. We also observed significant decrease in energy and cholesterol consumption in patients with NAFLD after the multidisciplinary therapy. CONCLUSIONS: The intervention promoted a decrease in the prevalence of NAFLD, a significant decrease in visceral obesity, and improved HOMA-IR, glycemia, and serum lipid levels that are risk factors for NAFLD. In summary, the multidisciplinary program is essential in the treatment and prevention of NAFLD. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/17414142/Metabolic_and_nutritional_profile_of_obese_adolescents_with_nonalcoholic_fatty_liver_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=17414142 DB - PRIME DP - Unbound Medicine ER -