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Role of branched-chain amino acids in liver disease: the evidence for and against.
Curr Opin Clin Nutr Metab Care 2007; 10(3):297-303CO

Abstract

PURPOSE OF REVIEW

There is ample evidence that patients with liver disease have an ongoing energy and protein catabolism. Nutritional management in these patients must receive high priority. The administration of branched-chain amino acids to patients with liver disease has been a controversial subject. This review is an update on the data available from various studies involving branched-chain amino acids supplementation in patients with chronic liver disease and associated complications.

RECENT FINDINGS

This review summarizes the results of nutritional interventions involving branched-chain amino acids supplementation carried out in different centres around the world. It is interesting to note that no toxic effects of branched-chain amino acids supplementation have been reported in any of these trials.

SUMMARY

Administration of branched-chain amino acids stimulates hepatic protein synthesis in patients with chronic liver disease and this could contribute significantly to improving their nutritional status, and result in a better quality of life. The beneficial role of branched-chain amino acids supplementation in patients with chronic hepatic encephalopathy has been clearly documented in some studies but the exact mechanism of action is still not clear.

Authors+Show Affiliations

Pushpawati Singhania Research Institute for Liver, Renal and Digestive Diseases, Press Enclave Road, New Delhi 110017, India. khannasudeep@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17414498

Citation

Khanna, Sudeep, and Sarath Gopalan. "Role of Branched-chain Amino Acids in Liver Disease: the Evidence for and Against." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 10, no. 3, 2007, pp. 297-303.
Khanna S, Gopalan S. Role of branched-chain amino acids in liver disease: the evidence for and against. Curr Opin Clin Nutr Metab Care. 2007;10(3):297-303.
Khanna, S., & Gopalan, S. (2007). Role of branched-chain amino acids in liver disease: the evidence for and against. Current Opinion in Clinical Nutrition and Metabolic Care, 10(3), pp. 297-303.
Khanna S, Gopalan S. Role of Branched-chain Amino Acids in Liver Disease: the Evidence for and Against. Curr Opin Clin Nutr Metab Care. 2007;10(3):297-303. PubMed PMID: 17414498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of branched-chain amino acids in liver disease: the evidence for and against. AU - Khanna,Sudeep, AU - Gopalan,Sarath, PY - 2007/4/7/pubmed PY - 2007/6/26/medline PY - 2007/4/7/entrez SP - 297 EP - 303 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 10 IS - 3 N2 - PURPOSE OF REVIEW: There is ample evidence that patients with liver disease have an ongoing energy and protein catabolism. Nutritional management in these patients must receive high priority. The administration of branched-chain amino acids to patients with liver disease has been a controversial subject. This review is an update on the data available from various studies involving branched-chain amino acids supplementation in patients with chronic liver disease and associated complications. RECENT FINDINGS: This review summarizes the results of nutritional interventions involving branched-chain amino acids supplementation carried out in different centres around the world. It is interesting to note that no toxic effects of branched-chain amino acids supplementation have been reported in any of these trials. SUMMARY: Administration of branched-chain amino acids stimulates hepatic protein synthesis in patients with chronic liver disease and this could contribute significantly to improving their nutritional status, and result in a better quality of life. The beneficial role of branched-chain amino acids supplementation in patients with chronic hepatic encephalopathy has been clearly documented in some studies but the exact mechanism of action is still not clear. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/17414498/Role_of_branched_chain_amino_acids_in_liver_disease:_the_evidence_for_and_against_ L2 - http://Insights.ovid.com/pubmed?pmid=17414498 DB - PRIME DP - Unbound Medicine ER -