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Factors affecting reproductive hormones in HIV-infected, substance-using middle-aged women.
Menopause. 2007 Sep-Oct; 14(5):859-65.M

Abstract

OBJECTIVE

To determine whether reproductive hormone levels are affected by human immunodeficiency virus (HIV) and drug use.

DESIGN

HIV-infected and uninfected women (N=429), median age 45, were interviewed on menstrual frequency, demographic and psychosocial characteristics, and drug use behaviors. Serum was obtained on cycle days 1 to 5 in women reporting regular menses. Premenopausal-, early menopausal, and late menopausal transition and postmenopausal stages were assigned based on menstrual history. Serum was assayed for follicle-stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH), prolactin, thyroid-stimulating hormone, and inhibin B. Body mass index, HIV serostatus, and CD4+ counts were measured. Factors associated with hormone concentrations were assessed using uni- and multivariable analyses. Hormone concentrations were compared within menstrual status categories using nonparametric comparisons of means.

RESULTS

In this cross-sectional analysis, LH and FSH increased, and E2 and inhibin B were significantly lower in women of older age and more advanced menopausal status. Increased body mass index was strongly associated with decreased LH. Opiate use was significantly associated with lower inhibin B and E2 and increased prolactin. Poorer self-rated health was statistically significantly associated with lower LH and FSH, but increased education was associated with higher LH and FSH. Among HIV-seropositive women, opiate users had detectably lower FSH and LH than nonusers, and use of highly active antiretroviral therapy was significantly related to higher LH, FSH, and E2, whereas cocaine use was associated with lower E2.

CONCLUSIONS

Age and menopausal status are strongly related to reproductive hormones. Body mass index and use of opiates, cocaine, and highly active antiretroviral therapy as well as educational attainment and perceived health can significantly modify reproductive hormones during the menopausal transition and need to be considered when interpreting hormone levels in middle-aged women.

Authors+Show Affiliations

Department of Obstetrics, Gynecology, and Women's Health, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA. glicktoro@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17415019

Citation

Santoro, Nanette, et al. "Factors Affecting Reproductive Hormones in HIV-infected, Substance-using Middle-aged Women." Menopause (New York, N.Y.), vol. 14, no. 5, 2007, pp. 859-65.
Santoro N, Lo Y, Moskaleva G, et al. Factors affecting reproductive hormones in HIV-infected, substance-using middle-aged women. Menopause. 2007;14(5):859-65.
Santoro, N., Lo, Y., Moskaleva, G., Arnsten, J. H., Floris-Moore, M., Howard, A. A., Adel, G., Zeitlian, G., & Schoenbaum, E. E. (2007). Factors affecting reproductive hormones in HIV-infected, substance-using middle-aged women. Menopause (New York, N.Y.), 14(5), 859-65.
Santoro N, et al. Factors Affecting Reproductive Hormones in HIV-infected, Substance-using Middle-aged Women. Menopause. 2007 Sep-Oct;14(5):859-65. PubMed PMID: 17415019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors affecting reproductive hormones in HIV-infected, substance-using middle-aged women. AU - Santoro,Nanette, AU - Lo,Yungtai, AU - Moskaleva,Galina, AU - Arnsten,Julia H, AU - Floris-Moore,Michelle, AU - Howard,Andrea A, AU - Adel,Goli, AU - Zeitlian,Gohar, AU - Schoenbaum,Ellie E, PY - 2007/4/7/pubmed PY - 2007/12/19/medline PY - 2007/4/7/entrez SP - 859 EP - 65 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 5 N2 - OBJECTIVE: To determine whether reproductive hormone levels are affected by human immunodeficiency virus (HIV) and drug use. DESIGN: HIV-infected and uninfected women (N=429), median age 45, were interviewed on menstrual frequency, demographic and psychosocial characteristics, and drug use behaviors. Serum was obtained on cycle days 1 to 5 in women reporting regular menses. Premenopausal-, early menopausal, and late menopausal transition and postmenopausal stages were assigned based on menstrual history. Serum was assayed for follicle-stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH), prolactin, thyroid-stimulating hormone, and inhibin B. Body mass index, HIV serostatus, and CD4+ counts were measured. Factors associated with hormone concentrations were assessed using uni- and multivariable analyses. Hormone concentrations were compared within menstrual status categories using nonparametric comparisons of means. RESULTS: In this cross-sectional analysis, LH and FSH increased, and E2 and inhibin B were significantly lower in women of older age and more advanced menopausal status. Increased body mass index was strongly associated with decreased LH. Opiate use was significantly associated with lower inhibin B and E2 and increased prolactin. Poorer self-rated health was statistically significantly associated with lower LH and FSH, but increased education was associated with higher LH and FSH. Among HIV-seropositive women, opiate users had detectably lower FSH and LH than nonusers, and use of highly active antiretroviral therapy was significantly related to higher LH, FSH, and E2, whereas cocaine use was associated with lower E2. CONCLUSIONS: Age and menopausal status are strongly related to reproductive hormones. Body mass index and use of opiates, cocaine, and highly active antiretroviral therapy as well as educational attainment and perceived health can significantly modify reproductive hormones during the menopausal transition and need to be considered when interpreting hormone levels in middle-aged women. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17415019/Factors_affecting_reproductive_hormones_in_HIV_infected_substance_using_middle_aged_women_ L2 - https://doi.org/10.1097/GME.0b013e31802f7369 DB - PRIME DP - Unbound Medicine ER -