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Magnetic resonance analysis of amygdalar volume in Alzheimer's disease.

Abstract

PURPOSE OF REVIEW

With the rising prevalence of Alzheimer's disease, there is an increasing need for better comprehension of its pathophysiology. The purpose of this article is to review recent studies investigating the association between amygdalar volume and clinical symptoms in Alzheimer's disease. The first part describes the technique of MRI segmentation of amygdala. The advantages and risks of various segmentation techniques are noted. In the second part, the role of amygdalar volume in the assessment of clinical diagnosis is discussed. The third part encounters the relationship between the amygdalar atrophy and its neuropsychological correlates.

RECENT FINDINGS

Numerous MRI studies showed the same degree of hippocampal and amygdalar volume loss. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease. Asymmetry in amygdalar atrophy is useful in separating Alzheimer's disease and frontotemporal lobar degeneration. There has been a lack of direct relationship between the atrophy of amygdala and neuropsychiatric symptoms in Alzheimer's disease.

SUMMARY

Although time-consuming, the manual tracing represents the golden standard in MRI volumetry of amygdala. The pathogenesis of neuropsychiatric symptoms in Alzheimer's disease is complex and their manifestation is therefore not attributable to the amygdalar atrophy only.

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  • Authors+Show Affiliations

    ,

    Institute of Pathological Physiology, Department of Neurology, 2nd School of Medicine, Czech Republic cDepartment of Neurosurgery, 1st School of Medicine, Charles University, Prague, Czech Republic. daniel.horinek@uvn.cz

    ,

    Source

    Current opinion in psychiatry 20:3 2007 May pg 273-7

    MeSH

    Aged
    Alzheimer Disease
    Amygdala
    Atrophy
    Dementia
    Diagnosis, Differential
    Emotions
    Hippocampus
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Memory
    Neuropsychological Tests
    Sensitivity and Specificity

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    17415082

    Citation

    Horínek, Daniel, et al. "Magnetic Resonance Analysis of Amygdalar Volume in Alzheimer's Disease." Current Opinion in Psychiatry, vol. 20, no. 3, 2007, pp. 273-7.
    Horínek D, Varjassyová A, Hort J. Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. Curr Opin Psychiatry. 2007;20(3):273-7.
    Horínek, D., Varjassyová, A., & Hort, J. (2007). Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. Current Opinion in Psychiatry, 20(3), pp. 273-7.
    Horínek D, Varjassyová A, Hort J. Magnetic Resonance Analysis of Amygdalar Volume in Alzheimer's Disease. Curr Opin Psychiatry. 2007;20(3):273-7. PubMed PMID: 17415082.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. AU - Horínek,Daniel, AU - Varjassyová,Alexandra, AU - Hort,Jakub, PY - 2007/4/7/pubmed PY - 2007/7/17/medline PY - 2007/4/7/entrez SP - 273 EP - 7 JF - Current opinion in psychiatry JO - Curr Opin Psychiatry VL - 20 IS - 3 N2 - PURPOSE OF REVIEW: With the rising prevalence of Alzheimer's disease, there is an increasing need for better comprehension of its pathophysiology. The purpose of this article is to review recent studies investigating the association between amygdalar volume and clinical symptoms in Alzheimer's disease. The first part describes the technique of MRI segmentation of amygdala. The advantages and risks of various segmentation techniques are noted. In the second part, the role of amygdalar volume in the assessment of clinical diagnosis is discussed. The third part encounters the relationship between the amygdalar atrophy and its neuropsychological correlates. RECENT FINDINGS: Numerous MRI studies showed the same degree of hippocampal and amygdalar volume loss. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease. Asymmetry in amygdalar atrophy is useful in separating Alzheimer's disease and frontotemporal lobar degeneration. There has been a lack of direct relationship between the atrophy of amygdala and neuropsychiatric symptoms in Alzheimer's disease. SUMMARY: Although time-consuming, the manual tracing represents the golden standard in MRI volumetry of amygdala. The pathogenesis of neuropsychiatric symptoms in Alzheimer's disease is complex and their manifestation is therefore not attributable to the amygdalar atrophy only. SN - 0951-7367 UR - https://www.unboundmedicine.com/medline/citation/17415082/Magnetic_resonance_analysis_of_amygdalar_volume_in_Alzheimer's_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=17415082 DB - PRIME DP - Unbound Medicine ER -