Tags

Type your tag names separated by a space and hit enter

Magnetic resonance analysis of amygdalar volume in Alzheimer's disease.
Curr Opin Psychiatry 2007; 20(3):273-7CO

Abstract

PURPOSE OF REVIEW

With the rising prevalence of Alzheimer's disease, there is an increasing need for better comprehension of its pathophysiology. The purpose of this article is to review recent studies investigating the association between amygdalar volume and clinical symptoms in Alzheimer's disease. The first part describes the technique of MRI segmentation of amygdala. The advantages and risks of various segmentation techniques are noted. In the second part, the role of amygdalar volume in the assessment of clinical diagnosis is discussed. The third part encounters the relationship between the amygdalar atrophy and its neuropsychological correlates.

RECENT FINDINGS

Numerous MRI studies showed the same degree of hippocampal and amygdalar volume loss. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease. Asymmetry in amygdalar atrophy is useful in separating Alzheimer's disease and frontotemporal lobar degeneration. There has been a lack of direct relationship between the atrophy of amygdala and neuropsychiatric symptoms in Alzheimer's disease.

SUMMARY

Although time-consuming, the manual tracing represents the golden standard in MRI volumetry of amygdala. The pathogenesis of neuropsychiatric symptoms in Alzheimer's disease is complex and their manifestation is therefore not attributable to the amygdalar atrophy only.

Authors+Show Affiliations

Institute of Pathological Physiology, Department of Neurology, 2nd School of Medicine, Czech Republic cDepartment of Neurosurgery, 1st School of Medicine, Charles University, Prague, Czech Republic. daniel.horinek@uvn.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17415082

Citation

Horínek, Daniel, et al. "Magnetic Resonance Analysis of Amygdalar Volume in Alzheimer's Disease." Current Opinion in Psychiatry, vol. 20, no. 3, 2007, pp. 273-7.
Horínek D, Varjassyová A, Hort J. Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. Curr Opin Psychiatry. 2007;20(3):273-7.
Horínek, D., Varjassyová, A., & Hort, J. (2007). Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. Current Opinion in Psychiatry, 20(3), pp. 273-7.
Horínek D, Varjassyová A, Hort J. Magnetic Resonance Analysis of Amygdalar Volume in Alzheimer's Disease. Curr Opin Psychiatry. 2007;20(3):273-7. PubMed PMID: 17415082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. AU - Horínek,Daniel, AU - Varjassyová,Alexandra, AU - Hort,Jakub, PY - 2007/4/7/pubmed PY - 2007/7/17/medline PY - 2007/4/7/entrez SP - 273 EP - 7 JF - Current opinion in psychiatry JO - Curr Opin Psychiatry VL - 20 IS - 3 N2 - PURPOSE OF REVIEW: With the rising prevalence of Alzheimer's disease, there is an increasing need for better comprehension of its pathophysiology. The purpose of this article is to review recent studies investigating the association between amygdalar volume and clinical symptoms in Alzheimer's disease. The first part describes the technique of MRI segmentation of amygdala. The advantages and risks of various segmentation techniques are noted. In the second part, the role of amygdalar volume in the assessment of clinical diagnosis is discussed. The third part encounters the relationship between the amygdalar atrophy and its neuropsychological correlates. RECENT FINDINGS: Numerous MRI studies showed the same degree of hippocampal and amygdalar volume loss. MRI volumetry of the amygdala may be relevant as a marker of dementia severity in Alzheimer's disease. Asymmetry in amygdalar atrophy is useful in separating Alzheimer's disease and frontotemporal lobar degeneration. There has been a lack of direct relationship between the atrophy of amygdala and neuropsychiatric symptoms in Alzheimer's disease. SUMMARY: Although time-consuming, the manual tracing represents the golden standard in MRI volumetry of amygdala. The pathogenesis of neuropsychiatric symptoms in Alzheimer's disease is complex and their manifestation is therefore not attributable to the amygdalar atrophy only. SN - 0951-7367 UR - https://www.unboundmedicine.com/medline/citation/17415082/Magnetic_resonance_analysis_of_amygdalar_volume_in_Alzheimer's_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=17415082 DB - PRIME DP - Unbound Medicine ER -