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Zinc and the liver: an active interaction.
Dig Dis Sci 2007; 52(7):1595-612DD

Abstract

Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver function. Decreased zinc levels have been implicated in both acute and chronic liver disease states, and zinc deficiency has been implicated in the pathogenesis of liver diseases. Zinc supplementation offers protection in experimental animal models of acute and chronic liver injury, but these hepatoprotective properties have not been fully elucidated. In the present review, data on zinc homeostasis, its implication in the pathogenesis of liver diseases, and its effect on acute and chronic liver diseases are presented. It is concluded that zinc could protect against liver diseases, although up to now the underlying pathophysiology of zinc and liver interactions have not been defined.

Authors+Show Affiliations

Department of Forensic Medicine and Toxicology, University of Athens, Medical School, Goudi, Athens, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17415640

Citation

Stamoulis, Ioannis, et al. "Zinc and the Liver: an Active Interaction." Digestive Diseases and Sciences, vol. 52, no. 7, 2007, pp. 1595-612.
Stamoulis I, Kouraklis G, Theocharis S. Zinc and the liver: an active interaction. Dig Dis Sci. 2007;52(7):1595-612.
Stamoulis, I., Kouraklis, G., & Theocharis, S. (2007). Zinc and the liver: an active interaction. Digestive Diseases and Sciences, 52(7), pp. 1595-612.
Stamoulis I, Kouraklis G, Theocharis S. Zinc and the Liver: an Active Interaction. Dig Dis Sci. 2007;52(7):1595-612. PubMed PMID: 17415640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc and the liver: an active interaction. AU - Stamoulis,Ioannis, AU - Kouraklis,Grigorios, AU - Theocharis,Stamatios, Y1 - 2007/04/06/ PY - 2006/04/10/received PY - 2006/05/19/accepted PY - 2007/4/7/pubmed PY - 2007/9/7/medline PY - 2007/4/7/entrez SP - 1595 EP - 612 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 52 IS - 7 N2 - Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver function. Decreased zinc levels have been implicated in both acute and chronic liver disease states, and zinc deficiency has been implicated in the pathogenesis of liver diseases. Zinc supplementation offers protection in experimental animal models of acute and chronic liver injury, but these hepatoprotective properties have not been fully elucidated. In the present review, data on zinc homeostasis, its implication in the pathogenesis of liver diseases, and its effect on acute and chronic liver diseases are presented. It is concluded that zinc could protect against liver diseases, although up to now the underlying pathophysiology of zinc and liver interactions have not been defined. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/17415640/Zinc_and_the_liver:_an_active_interaction_ L2 - https://doi.org/10.1007/s10620-006-9462-0 DB - PRIME DP - Unbound Medicine ER -