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Chronic hypergastrinemia: causes and consequences.
Dig Dis Sci. 2007 Oct; 52(10):2482-9.DD

Abstract

The hormone gastrin plays 2 important roles in gastrointestinal physiology--1 as a major factor in meal-stimulated gastric acid secretion and the other as a trophic hormone for epithelial and enterochromaffin cells. These roles are exaggerated to the point of pathology under conditions of chronic hypergastrinemia as exemplified by the Zollinger-Ellison syndrome and pernicious anemia. More recently, the concern about the potential risk of chronic hypergastrinemia has risen because of the widespread use of proton pump inhibitors for maintenance therapy in reflux esophagitis. For this reason, we present a concise overview of the origin, causes, and potential risks of chronic hypergastrinemia.

Authors+Show Affiliations

Duke University Center for Clinical Health Policy and Durham VA, Durham, North Carolina, USA. orlan002@mc.duke.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17415644

Citation

Orlando, Lori A., et al. "Chronic Hypergastrinemia: Causes and Consequences." Digestive Diseases and Sciences, vol. 52, no. 10, 2007, pp. 2482-9.
Orlando LA, Lenard L, Orlando RC. Chronic hypergastrinemia: causes and consequences. Dig Dis Sci. 2007;52(10):2482-9.
Orlando, L. A., Lenard, L., & Orlando, R. C. (2007). Chronic hypergastrinemia: causes and consequences. Digestive Diseases and Sciences, 52(10), 2482-9.
Orlando LA, Lenard L, Orlando RC. Chronic Hypergastrinemia: Causes and Consequences. Dig Dis Sci. 2007;52(10):2482-9. PubMed PMID: 17415644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic hypergastrinemia: causes and consequences. AU - Orlando,Lori A, AU - Lenard,Lane, AU - Orlando,Roy C, Y1 - 2007/04/06/ PY - 2006/04/24/received PY - 2006/04/30/accepted PY - 2007/4/7/pubmed PY - 2007/10/27/medline PY - 2007/4/7/entrez SP - 2482 EP - 9 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 52 IS - 10 N2 - The hormone gastrin plays 2 important roles in gastrointestinal physiology--1 as a major factor in meal-stimulated gastric acid secretion and the other as a trophic hormone for epithelial and enterochromaffin cells. These roles are exaggerated to the point of pathology under conditions of chronic hypergastrinemia as exemplified by the Zollinger-Ellison syndrome and pernicious anemia. More recently, the concern about the potential risk of chronic hypergastrinemia has risen because of the widespread use of proton pump inhibitors for maintenance therapy in reflux esophagitis. For this reason, we present a concise overview of the origin, causes, and potential risks of chronic hypergastrinemia. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/17415644/Chronic_hypergastrinemia:_causes_and_consequences_ L2 - https://doi.org/10.1007/s10620-006-9419-3 DB - PRIME DP - Unbound Medicine ER -