Tags

Type your tag names separated by a space and hit enter

Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health study.

Abstract

Obesity and menopausal estrogen therapy are established risk factors for endometrial cancer. However, the joint effects of obesity and menopausal hormone therapy on endometrial cancer risk are incompletely understood. We addressed this issue in a cohort of 103,882 women ages 50 to 71 years at baseline in 1995 to 1996. During a median of 4.6 years, which contributed to a total of 455,304 person-years of follow-up through 2000, 677 cases of endometrial cancer were ascertained. Both baseline body mass index (BMI) and adult weight gain were associated with increased endometrial cancer risk. The multivariate relative risk (RR) comparing obese with normal weight women (BMI >30 versus <25 kg/m(2)) was 3.03 [95% confidence interval (95% CI), 2.50-3.68]. Compared with women with stable weight (gained or lost <5 kg) between age 18 and baseline, women who gained >or=20 kg had a RR of 2.75 (95% CI, 1.96-3.86). Menopausal hormone therapy significantly modified the relations of BMI (P(interaction) < 0.001) and adult weight gain (P(interaction) = 0.004) to endometrial cancer risk. Compared with normal weight, the RRs for obesity were 5.41 (95% CI, 4.01-7.29) among women who never used menopausal hormone therapy, 2.53 (95% CI, 1.21-5.30) among former menopausal hormone therapy users, and 1.44 (95% CI, 1.00-2.05) among current users. Compared with a stable weight between age 18 and baseline, the RRs for weight gain of >or=20 kg among never users and ever users of menopausal hormone therapy were 5.35 (95% CI, 3.01-9.52) and 1.43 (95% CI, 0.96-2.15), respectively. We conclude that both current adiposity and adult weight gain are associated with substantial increases in the risk of endometrial cancer, with relations particularly evident among never users of menopausal hormone therapy.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 320, Executive Plaza South, MSC7232, Bethesda, MD 20892-7232, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17416763

Citation

Chang, Shih-Chen, et al. "Lifetime Weight History and Endometrial Cancer Risk By Type of Menopausal Hormone Use in the NIH-AARP Diet and Health Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 16, no. 4, 2007, pp. 723-30.
Chang SC, Lacey JV, Brinton LA, et al. Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health study. Cancer Epidemiol Biomarkers Prev. 2007;16(4):723-30.
Chang, S. C., Lacey, J. V., Brinton, L. A., Hartge, P., Adams, K., Mouw, T., ... Leitzmann, M. F. (2007). Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 16(4), pp. 723-30.
Chang SC, et al. Lifetime Weight History and Endometrial Cancer Risk By Type of Menopausal Hormone Use in the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev. 2007;16(4):723-30. PubMed PMID: 17416763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health study. AU - Chang,Shih-Chen, AU - Lacey,James V,Jr AU - Brinton,Louise A, AU - Hartge,Patricia, AU - Adams,Kenneth, AU - Mouw,Traci, AU - Carroll,Leslie, AU - Hollenbeck,Albert, AU - Schatzkin,Arthur, AU - Leitzmann,Michael F, PY - 2007/4/10/pubmed PY - 2007/6/6/medline PY - 2007/4/10/entrez SP - 723 EP - 30 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 16 IS - 4 N2 - Obesity and menopausal estrogen therapy are established risk factors for endometrial cancer. However, the joint effects of obesity and menopausal hormone therapy on endometrial cancer risk are incompletely understood. We addressed this issue in a cohort of 103,882 women ages 50 to 71 years at baseline in 1995 to 1996. During a median of 4.6 years, which contributed to a total of 455,304 person-years of follow-up through 2000, 677 cases of endometrial cancer were ascertained. Both baseline body mass index (BMI) and adult weight gain were associated with increased endometrial cancer risk. The multivariate relative risk (RR) comparing obese with normal weight women (BMI >30 versus <25 kg/m(2)) was 3.03 [95% confidence interval (95% CI), 2.50-3.68]. Compared with women with stable weight (gained or lost <5 kg) between age 18 and baseline, women who gained >or=20 kg had a RR of 2.75 (95% CI, 1.96-3.86). Menopausal hormone therapy significantly modified the relations of BMI (P(interaction) < 0.001) and adult weight gain (P(interaction) = 0.004) to endometrial cancer risk. Compared with normal weight, the RRs for obesity were 5.41 (95% CI, 4.01-7.29) among women who never used menopausal hormone therapy, 2.53 (95% CI, 1.21-5.30) among former menopausal hormone therapy users, and 1.44 (95% CI, 1.00-2.05) among current users. Compared with a stable weight between age 18 and baseline, the RRs for weight gain of >or=20 kg among never users and ever users of menopausal hormone therapy were 5.35 (95% CI, 3.01-9.52) and 1.43 (95% CI, 0.96-2.15), respectively. We conclude that both current adiposity and adult weight gain are associated with substantial increases in the risk of endometrial cancer, with relations particularly evident among never users of menopausal hormone therapy. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17416763/Lifetime_weight_history_and_endometrial_cancer_risk_by_type_of_menopausal_hormone_use_in_the_NIH_AARP_diet_and_health_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=17416763 DB - PRIME DP - Unbound Medicine ER -