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Effects of aerobic exercise training on estrogen metabolism in premenopausal women: a randomized controlled trial.

Abstract

BACKGROUND

Regular physical activity may alter estrogen metabolism, a proposed biomarker of breast cancer risk, by shifting metabolism to favor production of 2-hydroxyestrone (2-OHE1). Few studies, however, have examined this question using a randomized controlled trial.

PURPOSE

To examine the effects of 12 weeks of aerobic exercise training on 2-OHE1 and 16alpha-hydroxyestrone (16alpha-OHE1) in premenopausal women.

METHODS

Participants were healthy, regularly menstruating, Caucasian women, 20 to 35 years, body mass index of 18 to 29.9, not using pharmacologic contraceptives, with average or below average fitness [maximal oxygen consumption (VO(2max)), <40 mL/kg/min]. Following a baseline menstrual cycle, participants (N = 32) were randomly assigned to a 12-week aerobic exercise training intervention (n = 17) or usual lifestyle (n = 15). Height, body mass, body composition by dual-energy X-ray absorptiometry, and VO(2max) were measured at baseline and following the intervention. Urine samples were collected in the luteal phase of four consecutive menstrual cycles.

RESULTS

The exercise group increased VO(2max) by 14% and had significant, although modest, improvements in fat and lean body mass. No significant between-group differences were observed, however, for the changes in 2-OHE1 (P = 0.944), 16alpha-OHE1 (P = 0.411), or the ratio of 2-OHE1 to 16alpha-OHE1 (P = 0.317). At baseline, there was an inverse association between body fat and 2-OHE1 to 16alpha-OHE1 ratio (r = -0.40; P = 0.044); however, it was the change in lean body mass over the intervention that was positively associated with a change in 2-OHE1 to 16alpha-OHE1 ratio (r = 0.43; P = 0.015).

CONCLUSIONS

A 12-week aerobic exercise training intervention significantly improved aerobic fitness and body composition but did not alter estrogen metabolism in premenopausal women. Interestingly, an increase in lean body mass was associated with a favorable change in 2-OHE1 to 16alpha-OHE1 ratio.

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  • Authors+Show Affiliations

    ,

    E-488 Van Vliet Centre, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada T6G 2H9.

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    Source

    MeSH

    Absorptiometry, Photon
    Adult
    Alberta
    Analysis of Variance
    Body Composition
    Body Height
    Body Mass Index
    Diet
    Enzyme-Linked Immunosorbent Assay
    Exercise
    Female
    Humans
    Hydroxyestrones
    Oxygen Consumption
    Premenopause

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17416764

    Citation

    Campbell, Kristin L., et al. "Effects of Aerobic Exercise Training On Estrogen Metabolism in Premenopausal Women: a Randomized Controlled Trial." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 16, no. 4, 2007, pp. 731-9.
    Campbell KL, Westerlind KC, Harber VJ, et al. Effects of aerobic exercise training on estrogen metabolism in premenopausal women: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev. 2007;16(4):731-9.
    Campbell, K. L., Westerlind, K. C., Harber, V. J., Bell, G. J., Mackey, J. R., & Courneya, K. S. (2007). Effects of aerobic exercise training on estrogen metabolism in premenopausal women: a randomized controlled trial. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 16(4), pp. 731-9.
    Campbell KL, et al. Effects of Aerobic Exercise Training On Estrogen Metabolism in Premenopausal Women: a Randomized Controlled Trial. Cancer Epidemiol Biomarkers Prev. 2007;16(4):731-9. PubMed PMID: 17416764.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of aerobic exercise training on estrogen metabolism in premenopausal women: a randomized controlled trial. AU - Campbell,Kristin L, AU - Westerlind,Kim C, AU - Harber,Vicki J, AU - Bell,Gordon J, AU - Mackey,John R, AU - Courneya,Kerry S, PY - 2007/4/10/pubmed PY - 2007/6/6/medline PY - 2007/4/10/entrez SP - 731 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 16 IS - 4 N2 - BACKGROUND: Regular physical activity may alter estrogen metabolism, a proposed biomarker of breast cancer risk, by shifting metabolism to favor production of 2-hydroxyestrone (2-OHE1). Few studies, however, have examined this question using a randomized controlled trial. PURPOSE: To examine the effects of 12 weeks of aerobic exercise training on 2-OHE1 and 16alpha-hydroxyestrone (16alpha-OHE1) in premenopausal women. METHODS: Participants were healthy, regularly menstruating, Caucasian women, 20 to 35 years, body mass index of 18 to 29.9, not using pharmacologic contraceptives, with average or below average fitness [maximal oxygen consumption (VO(2max)), <40 mL/kg/min]. Following a baseline menstrual cycle, participants (N = 32) were randomly assigned to a 12-week aerobic exercise training intervention (n = 17) or usual lifestyle (n = 15). Height, body mass, body composition by dual-energy X-ray absorptiometry, and VO(2max) were measured at baseline and following the intervention. Urine samples were collected in the luteal phase of four consecutive menstrual cycles. RESULTS: The exercise group increased VO(2max) by 14% and had significant, although modest, improvements in fat and lean body mass. No significant between-group differences were observed, however, for the changes in 2-OHE1 (P = 0.944), 16alpha-OHE1 (P = 0.411), or the ratio of 2-OHE1 to 16alpha-OHE1 (P = 0.317). At baseline, there was an inverse association between body fat and 2-OHE1 to 16alpha-OHE1 ratio (r = -0.40; P = 0.044); however, it was the change in lean body mass over the intervention that was positively associated with a change in 2-OHE1 to 16alpha-OHE1 ratio (r = 0.43; P = 0.015). CONCLUSIONS: A 12-week aerobic exercise training intervention significantly improved aerobic fitness and body composition but did not alter estrogen metabolism in premenopausal women. Interestingly, an increase in lean body mass was associated with a favorable change in 2-OHE1 to 16alpha-OHE1 ratio. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17416764/Effects_of_aerobic_exercise_training_on_estrogen_metabolism_in_premenopausal_women:_a_randomized_controlled_trial_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=17416764 DB - PRIME DP - Unbound Medicine ER -