Tags

Type your tag names separated by a space and hit enter

[Association of C1019T polymorphism in the connexin 37 gene and coronary artery disease in Chinese Han population].
Zhonghua Yi Xue Za Zhi. 2007 Jan 09; 87(2):100-4.ZY

Abstract

OBJECTIVE

To investigate the association between the connexin 37 (CX37) C1019T polymorphism and the susceptibility to coronary artery disease (CAD) in northern Han population of China.

METHODS

A total of 514 CAD patients and 400 healthy controls diagnosed by angiography were genotyped by using polymerase chain reaction-restriction fragment length polymorphism and polyacrylamide gel electrophoresis.

RESULTS

The genotype frequencies of CC, TC and TT in the CX37 C1019T polymorphism was 22.37%, 53.31% and 24.32% in CAD patients, 17.75%, 46.50% and 35.75% in the controls respectively (P = 0.0007). The frequency of the CX37 C allele in CAD patients was significantly higher than that of the control group (49.03% vs 41.00%, OR = 1.38, 95% CI = 1.15 - 1.66, P = 0.0006). The frequency of the C allele carriers (CC + TC) was 75.68% in the CAD group and 64.25% in the control group (P = 0.0002). Compared with the TT homozygote, the CAD risk was significantly increased in the carriers of C allele (CC + TC) (OR = 1.73, 95% CI = 1.30 - 2.30). Subsequent stratified analysis revealed that the frequency of C allele was significantly higher in the male CAD patients than in the male controls (49.37% vs 39.60%, OR = 1.49, 95% CI = 1.18 - 1.89, P = 0.0009). The CAD risk was nearly two-fold increased in the carriers of C allele (CC + TC) than in the TT homozygote (95% CI = 1.38 - 2.78). However in the female population, there was no difference in the CAD risk between the carriers of (CC + TC) type and the TT homozygote (P = 0.24).

CONCLUSION

The C allele in the CX37 gene might be associated with the susceptibility to CAD and potentially plays an important role in the manifestation of coronary atherosclerosis among Chinese.

Authors+Show Affiliations

Department of Cardiology, Shenyang General Hospital, Cardiovascular Research Institute of PLA, Shenyang 110016, China. hanyal@mail.sy.ln.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17418016

Citation

Han, Ya-Ling, et al. "[Association of C1019T Polymorphism in the Connexin 37 Gene and Coronary Artery Disease in Chinese Han Population]." Zhonghua Yi Xue Za Zhi, vol. 87, no. 2, 2007, pp. 100-4.
Han YL, Xi SY, Zhang XL, et al. [Association of C1019T polymorphism in the connexin 37 gene and coronary artery disease in Chinese Han population]. Zhonghua Yi Xue Za Zhi. 2007;87(2):100-4.
Han, Y. L., Xi, S. Y., Zhang, X. L., Yan, C. H., Yang, Y., & Kang, J. (2007). [Association of C1019T polymorphism in the connexin 37 gene and coronary artery disease in Chinese Han population]. Zhonghua Yi Xue Za Zhi, 87(2), 100-4.
Han YL, et al. [Association of C1019T Polymorphism in the Connexin 37 Gene and Coronary Artery Disease in Chinese Han Population]. Zhonghua Yi Xue Za Zhi. 2007 Jan 9;87(2):100-4. PubMed PMID: 17418016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of C1019T polymorphism in the connexin 37 gene and coronary artery disease in Chinese Han population]. AU - Han,Ya-Ling, AU - Xi,Su-Ya, AU - Zhang,Xiao-Lin, AU - Yan,Cheng-Hui, AU - Yang,Yong, AU - Kang,Jian, PY - 2007/4/10/pubmed PY - 2008/10/22/medline PY - 2007/4/10/entrez SP - 100 EP - 4 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 87 IS - 2 N2 - OBJECTIVE: To investigate the association between the connexin 37 (CX37) C1019T polymorphism and the susceptibility to coronary artery disease (CAD) in northern Han population of China. METHODS: A total of 514 CAD patients and 400 healthy controls diagnosed by angiography were genotyped by using polymerase chain reaction-restriction fragment length polymorphism and polyacrylamide gel electrophoresis. RESULTS: The genotype frequencies of CC, TC and TT in the CX37 C1019T polymorphism was 22.37%, 53.31% and 24.32% in CAD patients, 17.75%, 46.50% and 35.75% in the controls respectively (P = 0.0007). The frequency of the CX37 C allele in CAD patients was significantly higher than that of the control group (49.03% vs 41.00%, OR = 1.38, 95% CI = 1.15 - 1.66, P = 0.0006). The frequency of the C allele carriers (CC + TC) was 75.68% in the CAD group and 64.25% in the control group (P = 0.0002). Compared with the TT homozygote, the CAD risk was significantly increased in the carriers of C allele (CC + TC) (OR = 1.73, 95% CI = 1.30 - 2.30). Subsequent stratified analysis revealed that the frequency of C allele was significantly higher in the male CAD patients than in the male controls (49.37% vs 39.60%, OR = 1.49, 95% CI = 1.18 - 1.89, P = 0.0009). The CAD risk was nearly two-fold increased in the carriers of C allele (CC + TC) than in the TT homozygote (95% CI = 1.38 - 2.78). However in the female population, there was no difference in the CAD risk between the carriers of (CC + TC) type and the TT homozygote (P = 0.24). CONCLUSION: The C allele in the CX37 gene might be associated with the susceptibility to CAD and potentially plays an important role in the manifestation of coronary atherosclerosis among Chinese. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/17418016/[Association_of_C1019T_polymorphism_in_the_connexin_37_gene_and_coronary_artery_disease_in_Chinese_Han_population]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0376-2491&year=2007&vol=87&issue=2&fpage=100 DB - PRIME DP - Unbound Medicine ER -