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Non-traditional markers of atherosclerosis potentiate the risk of coronary heart disease in patients with type 2 diabetes and metabolic syndrome.
Nutr Metab Cardiovasc Dis 2008; 18(1):31-8NM

Abstract

BACKGROUND AND AIMS

The aims of this study were to establish the prevalence of metabolic syndrome (MS), in type 2 diabetes mellitus (DM), according to National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and to assess the association of MS with other cardiovascular (CV) risk factors in these patients.

METHODS AND RESULTS

A cross-sectional study was conducted in 1610 patients with type 2 DM. Glycated hemoglobin A1c (HbA1c), total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), uric acid, fibrinogen, creatinine, and albumin/creatinine ratios were measured. The risk of coronary heart disease (CHD) was calculated using the UKPDS Risk Engine. Seventy percent of the diabetic population met the criteria for MS; central obesity and hypertension were the most common criteria. Subjects with MS had higher levels of HbA1c, LDL-C, non-HDL-C, uric acid, and fibrinogen compared to patients without MS. Similarly, microalbuminuria and a high triglyceride (Tg)/HDL-C ratio (a marker of small LDL-C) occurred more frequently in patients with MS. When patients with no history of CHD events were considered, mean CHD risk was greater in those with, than those without, MS.

CONCLUSIONS

MS is highly prevalent in type 2 DM and is commonly associated with non-traditional CV risk factors. The diagnosis of MS seems to confer additional CHD risk in patients with type 2 diabetes.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Disease, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56126 Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17420118

Citation

Bianchi, Cristina, et al. "Non-traditional Markers of Atherosclerosis Potentiate the Risk of Coronary Heart Disease in Patients With Type 2 Diabetes and Metabolic Syndrome." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 18, no. 1, 2008, pp. 31-8.
Bianchi C, Penno G, Malloggi L, et al. Non-traditional markers of atherosclerosis potentiate the risk of coronary heart disease in patients with type 2 diabetes and metabolic syndrome. Nutr Metab Cardiovasc Dis. 2008;18(1):31-8.
Bianchi, C., Penno, G., Malloggi, L., Barontini, R., Corfini, M., Giovannitti, M. G., ... Miccoli, R. (2008). Non-traditional markers of atherosclerosis potentiate the risk of coronary heart disease in patients with type 2 diabetes and metabolic syndrome. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 18(1), pp. 31-8.
Bianchi C, et al. Non-traditional Markers of Atherosclerosis Potentiate the Risk of Coronary Heart Disease in Patients With Type 2 Diabetes and Metabolic Syndrome. Nutr Metab Cardiovasc Dis. 2008;18(1):31-8. PubMed PMID: 17420118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-traditional markers of atherosclerosis potentiate the risk of coronary heart disease in patients with type 2 diabetes and metabolic syndrome. AU - Bianchi,Cristina, AU - Penno,Giuseppe, AU - Malloggi,Lucia, AU - Barontini,Rossana, AU - Corfini,Marisa, AU - Giovannitti,Maria G, AU - Di Cianni,Graziano, AU - Del Prato,Stefano, AU - Miccoli,Roberto, Y1 - 2007/04/08/ PY - 2006/04/26/received PY - 2006/07/03/revised PY - 2006/07/14/accepted PY - 2007/4/11/pubmed PY - 2008/1/25/medline PY - 2007/4/11/entrez SP - 31 EP - 8 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 18 IS - 1 N2 - BACKGROUND AND AIMS: The aims of this study were to establish the prevalence of metabolic syndrome (MS), in type 2 diabetes mellitus (DM), according to National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and to assess the association of MS with other cardiovascular (CV) risk factors in these patients. METHODS AND RESULTS: A cross-sectional study was conducted in 1610 patients with type 2 DM. Glycated hemoglobin A1c (HbA1c), total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), uric acid, fibrinogen, creatinine, and albumin/creatinine ratios were measured. The risk of coronary heart disease (CHD) was calculated using the UKPDS Risk Engine. Seventy percent of the diabetic population met the criteria for MS; central obesity and hypertension were the most common criteria. Subjects with MS had higher levels of HbA1c, LDL-C, non-HDL-C, uric acid, and fibrinogen compared to patients without MS. Similarly, microalbuminuria and a high triglyceride (Tg)/HDL-C ratio (a marker of small LDL-C) occurred more frequently in patients with MS. When patients with no history of CHD events were considered, mean CHD risk was greater in those with, than those without, MS. CONCLUSIONS: MS is highly prevalent in type 2 DM and is commonly associated with non-traditional CV risk factors. The diagnosis of MS seems to confer additional CHD risk in patients with type 2 diabetes. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/17420118/Non_traditional_markers_of_atherosclerosis_potentiate_the_risk_of_coronary_heart_disease_in_patients_with_type_2_diabetes_and_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(06)00151-7 DB - PRIME DP - Unbound Medicine ER -