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Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease.
Arch Neurol. 2007 Apr; 64(4):576-80.AN

Abstract

OBJECTIVE

To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen).

DESIGN

Family-based case-control study.

SETTING

Academic medical center clinic.

PARTICIPANTS

A total of 356 case subjects and 317 family controls who self-reported environmental exposures.

MAIN OUTCOME MEASURES

Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and non-aspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex.

RESULTS

Individuals with PD were significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trend P = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD.

CONCLUSIONS

Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.

Authors+Show Affiliations

Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, NC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17420321

Citation

Hancock, Dana B., et al. "Smoking, Caffeine, and Nonsteroidal Anti-inflammatory Drugs in Families With Parkinson Disease." Archives of Neurology, vol. 64, no. 4, 2007, pp. 576-80.
Hancock DB, Martin ER, Stajich JM, et al. Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. Arch Neurol. 2007;64(4):576-80.
Hancock, D. B., Martin, E. R., Stajich, J. M., Jewett, R., Stacy, M. A., Scott, B. L., Vance, J. M., & Scott, W. K. (2007). Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. Archives of Neurology, 64(4), 576-80.
Hancock DB, et al. Smoking, Caffeine, and Nonsteroidal Anti-inflammatory Drugs in Families With Parkinson Disease. Arch Neurol. 2007;64(4):576-80. PubMed PMID: 17420321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. AU - Hancock,Dana B, AU - Martin,Eden R, AU - Stajich,Jeffrey M, AU - Jewett,Rita, AU - Stacy,Mark A, AU - Scott,Burton L, AU - Vance,Jeffery M, AU - Scott,William K, PY - 2007/4/11/pubmed PY - 2007/5/22/medline PY - 2007/4/11/entrez SP - 576 EP - 80 JF - Archives of neurology JO - Arch Neurol VL - 64 IS - 4 N2 - OBJECTIVE: To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). DESIGN: Family-based case-control study. SETTING: Academic medical center clinic. PARTICIPANTS: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. MAIN OUTCOME MEASURES: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and non-aspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. RESULTS: Individuals with PD were significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trend P = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. CONCLUSIONS: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/17420321/Smoking_caffeine_and_nonsteroidal_anti_inflammatory_drugs_in_families_with_Parkinson_disease_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.64.4.576 DB - PRIME DP - Unbound Medicine ER -