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Comparison of initial intraocular pressure response with topical beta-adrenergic antagonists and prostaglandin analogues in African American and white individuals in the Ocular Hypertension Treatment Study.
Arch Ophthalmol 2007; 125(4):454-9AO

Abstract

OBJECTIVE

To compare the intraocular pressure (IOP) responses of self-identified African American and white participants in the Ocular Hypertension Treatment Study to therapeutic trials of topical, nonselective beta-adrenergic antagonists or prostaglandin analogues.

METHODS

Multivariate models that adjusted for baseline IOP and corneal thickness were used to estimate IOP response by race. Participants included 536 who were prescribed topical beta-adrenergic antagonists and 191 who were prescribed prostaglandin analogues, 25% of whom were African American.

MAIN OUTCOME MEASURE

Intraocular pressure response in the ipsilateral eye after 4 to 6 weeks of a therapeutic trial.

RESULTS

Intraocular pressure response to nonselective beta-adrenergic antagonists did not differ between African American and white participants. Intraocular pressure response to prostaglandin analogues was slightly greater in African American participants, but this difference was not statistically significant. With both classes of medication, greater IOP reduction was associated with higher baseline IOP and thinner central corneal measurement.

CONCLUSIONS

We found no statistically significant differences in IOP response to topical, nonselective beta-adrenergic antagonists or prostaglandin analogues between self-identified African American and white individuals. Application to Clinical Practice Studies of IOP response to medication should statistically adjust for baseline IOP and central corneal thickness. Clinicians should consider factors other than ethnicity when choosing an ocular hypotensive medication for a patient.

TRIAL REGISTRATION

clinicaltrials.gov Identifier: NCT00000125.

Authors+Show Affiliations

Devers Eye Institute/Discoveries in Sight, Legacy Health System, Portland, Ore, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17420364

Citation

Mansberger, Steven L., et al. "Comparison of Initial Intraocular Pressure Response With Topical Beta-adrenergic Antagonists and Prostaglandin Analogues in African American and White Individuals in the Ocular Hypertension Treatment Study." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 125, no. 4, 2007, pp. 454-9.
Mansberger SL, Hughes BA, Gordon MO, et al. Comparison of initial intraocular pressure response with topical beta-adrenergic antagonists and prostaglandin analogues in African American and white individuals in the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2007;125(4):454-9.
Mansberger, S. L., Hughes, B. A., Gordon, M. O., Spaner, S. D., Beiser, J. A., Cioffi, G. A., & Kass, M. A. (2007). Comparison of initial intraocular pressure response with topical beta-adrenergic antagonists and prostaglandin analogues in African American and white individuals in the Ocular Hypertension Treatment Study. Archives of Ophthalmology (Chicago, Ill. : 1960), 125(4), pp. 454-9.
Mansberger SL, et al. Comparison of Initial Intraocular Pressure Response With Topical Beta-adrenergic Antagonists and Prostaglandin Analogues in African American and White Individuals in the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2007;125(4):454-9. PubMed PMID: 17420364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of initial intraocular pressure response with topical beta-adrenergic antagonists and prostaglandin analogues in African American and white individuals in the Ocular Hypertension Treatment Study. AU - Mansberger,Steven L, AU - Hughes,Bret A, AU - Gordon,Mae O, AU - Spaner,Steven D, AU - Beiser,Julia A, AU - Cioffi,George A, AU - Kass,Michael A, AU - ,, PY - 2007/4/11/pubmed PY - 2007/5/4/medline PY - 2007/4/11/entrez SP - 454 EP - 9 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 125 IS - 4 N2 - OBJECTIVE: To compare the intraocular pressure (IOP) responses of self-identified African American and white participants in the Ocular Hypertension Treatment Study to therapeutic trials of topical, nonselective beta-adrenergic antagonists or prostaglandin analogues. METHODS: Multivariate models that adjusted for baseline IOP and corneal thickness were used to estimate IOP response by race. Participants included 536 who were prescribed topical beta-adrenergic antagonists and 191 who were prescribed prostaglandin analogues, 25% of whom were African American. MAIN OUTCOME MEASURE: Intraocular pressure response in the ipsilateral eye after 4 to 6 weeks of a therapeutic trial. RESULTS: Intraocular pressure response to nonselective beta-adrenergic antagonists did not differ between African American and white participants. Intraocular pressure response to prostaglandin analogues was slightly greater in African American participants, but this difference was not statistically significant. With both classes of medication, greater IOP reduction was associated with higher baseline IOP and thinner central corneal measurement. CONCLUSIONS: We found no statistically significant differences in IOP response to topical, nonselective beta-adrenergic antagonists or prostaglandin analogues between self-identified African American and white individuals. Application to Clinical Practice Studies of IOP response to medication should statistically adjust for baseline IOP and central corneal thickness. Clinicians should consider factors other than ethnicity when choosing an ocular hypotensive medication for a patient. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00000125. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/17420364/Comparison_of_initial_intraocular_pressure_response_with_topical_beta_adrenergic_antagonists_and_prostaglandin_analogues_in_African_American_and_white_individuals_in_the_Ocular_Hypertension_Treatment_Study_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.125.4.454 DB - PRIME DP - Unbound Medicine ER -