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Nocturnal blood pressure changes in patients with restless legs syndrome.
Neurology. 2007 Apr 10; 68(15):1213-8.Neur

Abstract

OBJECTIVES

To assess heart rate (HR) and blood pressure (BP) changes associated with periodic leg movements during sleep (PLMS) with or without EEG signs of arousal in subjects with primary restless legs syndrome (RLS).

METHODS

Ten patients with RLS (4 women, aged 47.3 +/- 13.5 years) underwent one night of polysomnography along with noninvasive beat-to-beat BP monitoring. Ten PLMS with microarousals (PLMS-MA) and 10 PLMS without microarousals (PLMS-noMA) were analyzed in each subject. Systolic and diastolic BP (SBP, DBP) were measured within a 25-beat temporal window comprising 10 beats before and 15 beats after onset of each movement. PLMS-related BP changes were assessed by repeated measures one-way analysis of variance. BP changes associated with PLMS-MA and PLMS-noMA were compared by paired t-tests. Pearson correlation coefficients were used to assess the relationship between cardiovascular changes and clinical and polysomnographic variables.

RESULTS

BP increased significantly in association with all PLMS (on average, SBP 22 mm Hg, DBP 11 mm Hg). BP changes associated with PLMS-MA were greater vs those associated with PLMS-noMA (p < 0.05). SBP and DBP changes increased with age and the duration of illness.

CONCLUSIONS

Periodic leg movements-related repetitive nocturnal blood pressure fluctuations could contribute to the risk of cardiovascular diseases in patients with restless legs syndrome, especially in the elderly.

Authors+Show Affiliations

Sleep Disorders Center, Hôpital du Sacré-Coeur, University of Montréal, Montréal, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17420405

Citation

Pennestri, M H., et al. "Nocturnal Blood Pressure Changes in Patients With Restless Legs Syndrome." Neurology, vol. 68, no. 15, 2007, pp. 1213-8.
Pennestri MH, Montplaisir J, Colombo R, et al. Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology. 2007;68(15):1213-8.
Pennestri, M. H., Montplaisir, J., Colombo, R., Lavigne, G., & Lanfranchi, P. A. (2007). Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology, 68(15), 1213-8.
Pennestri MH, et al. Nocturnal Blood Pressure Changes in Patients With Restless Legs Syndrome. Neurology. 2007 Apr 10;68(15):1213-8. PubMed PMID: 17420405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nocturnal blood pressure changes in patients with restless legs syndrome. AU - Pennestri,M H, AU - Montplaisir,J, AU - Colombo,R, AU - Lavigne,G, AU - Lanfranchi,P A, PY - 2007/4/11/pubmed PY - 2007/5/2/medline PY - 2007/4/11/entrez SP - 1213 EP - 8 JF - Neurology JO - Neurology VL - 68 IS - 15 N2 - OBJECTIVES: To assess heart rate (HR) and blood pressure (BP) changes associated with periodic leg movements during sleep (PLMS) with or without EEG signs of arousal in subjects with primary restless legs syndrome (RLS). METHODS: Ten patients with RLS (4 women, aged 47.3 +/- 13.5 years) underwent one night of polysomnography along with noninvasive beat-to-beat BP monitoring. Ten PLMS with microarousals (PLMS-MA) and 10 PLMS without microarousals (PLMS-noMA) were analyzed in each subject. Systolic and diastolic BP (SBP, DBP) were measured within a 25-beat temporal window comprising 10 beats before and 15 beats after onset of each movement. PLMS-related BP changes were assessed by repeated measures one-way analysis of variance. BP changes associated with PLMS-MA and PLMS-noMA were compared by paired t-tests. Pearson correlation coefficients were used to assess the relationship between cardiovascular changes and clinical and polysomnographic variables. RESULTS: BP increased significantly in association with all PLMS (on average, SBP 22 mm Hg, DBP 11 mm Hg). BP changes associated with PLMS-MA were greater vs those associated with PLMS-noMA (p < 0.05). SBP and DBP changes increased with age and the duration of illness. CONCLUSIONS: Periodic leg movements-related repetitive nocturnal blood pressure fluctuations could contribute to the risk of cardiovascular diseases in patients with restless legs syndrome, especially in the elderly. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17420405/Nocturnal_blood_pressure_changes_in_patients_with_restless_legs_syndrome_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=17420405 DB - PRIME DP - Unbound Medicine ER -