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Zinc and other trace elements in liver cirrhosis.
Ital J Gastroenterol 1991 Jul-Aug; 23(6):386-91IJ

Abstract

Alterations in trace element concentrations may be observed in patients with chronic liver disease. Notably, selenium and zinc levels are reduced both in serum and in liver tissue of cirrhotic patients. Low selenium levels have been involved in the pathogenesis of liver damage as this element is important in controlling the levels of toxic oxygen radicals in the cells. Zinc deficiency has been involved in the pathogenesis of a number of clinical findings in chronic liver disease. These include the possible role of zinc deficiency in the pathogenesis of hepatic encephalopathy, by inducing alterations in urea metabolism. In CC14 cirrhotic rats oral zinc supplementation reduces ammonia levels and increases OCT activity in the liver. Oral zinc supplementation has been also proposed in the treatment of cirrhotic patients with chronic hepatic encephalopathy, the results however are not yet conclusive.

Authors+Show Affiliations

2. Gastroenterologia, Università La Sapienza, Roma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1742533

Citation

Capocaccia, L, et al. "Zinc and Other Trace Elements in Liver Cirrhosis." The Italian Journal of Gastroenterology, vol. 23, no. 6, 1991, pp. 386-91.
Capocaccia L, Merli M, Piat C, et al. Zinc and other trace elements in liver cirrhosis. Ital J Gastroenterol. 1991;23(6):386-91.
Capocaccia, L., Merli, M., Piat, C., Servi, R., Zullo, A., & Riggio, O. (1991). Zinc and other trace elements in liver cirrhosis. The Italian Journal of Gastroenterology, 23(6), pp. 386-91.
Capocaccia L, et al. Zinc and Other Trace Elements in Liver Cirrhosis. Ital J Gastroenterol. 1991;23(6):386-91. PubMed PMID: 1742533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc and other trace elements in liver cirrhosis. AU - Capocaccia,L, AU - Merli,M, AU - Piat,C, AU - Servi,R, AU - Zullo,A, AU - Riggio,O, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 386 EP - 91 JF - The Italian journal of gastroenterology JO - Ital J Gastroenterol VL - 23 IS - 6 N2 - Alterations in trace element concentrations may be observed in patients with chronic liver disease. Notably, selenium and zinc levels are reduced both in serum and in liver tissue of cirrhotic patients. Low selenium levels have been involved in the pathogenesis of liver damage as this element is important in controlling the levels of toxic oxygen radicals in the cells. Zinc deficiency has been involved in the pathogenesis of a number of clinical findings in chronic liver disease. These include the possible role of zinc deficiency in the pathogenesis of hepatic encephalopathy, by inducing alterations in urea metabolism. In CC14 cirrhotic rats oral zinc supplementation reduces ammonia levels and increases OCT activity in the liver. Oral zinc supplementation has been also proposed in the treatment of cirrhotic patients with chronic hepatic encephalopathy, the results however are not yet conclusive. SN - 0392-0623 UR - https://www.unboundmedicine.com/medline/citation/1742533/Zinc_and_other_trace_elements_in_liver_cirrhosis_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -