Tags

Type your tag names separated by a space and hit enter

OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology.
Int Wound J 2007; 4(1):3-7IW

Abstract

Mixed arterial/venous (A/V) ulcers are difficult to treat and slow to heal likely as a result of deficiencies in molecular and cellular elements in the wound bed. Recently, biomaterials have been developed that replace extracellular matrix (ECM) molecules and growth factors critical to the normal healing process. In this study, the effects of OASIS and Hyaloskin were evaluated to compare the effectiveness of these two ECM-based products in their ability to achieve complete wound healing of mixed A/V ulcers. After 16 weeks of treatment, patients in each group were evaluated on four criteria: complete wound healing, time to dressing change, pain and comfort. Complete wound closure was achieved in 82.6% of OASIS-treated ulcers compared with 46.2% of Hyaloskin-treated ulcers (P < 0.001). Statistically significant differences favouring the OASIS treatment group were also reported for time to dressing change (P < 0.05), pain (P < 0.05) and patient comfort (P < 0.01). Overall, OASIS was superior to Hyaloskin for the treatment of patients with mixed A/V ulcers, a population in which standard treatment options largely consist of moist wound dressings and compression therapy is typically not an option. OASIS is a useful and well-tolerated treatment for mixed A/V ulcers that has the potential to improve quality of life and reduce costs associated with standard of care.

Authors+Show Affiliations

Wound Healing Research Unit, Department of Dermatology, University of Pisa, Pisa, Italy. m.romanelli@med.unipit.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17425543

Citation

Romanelli, Marco, et al. "OASIS Wound Matrix Versus Hyaloskin in the Treatment of Difficult-to-heal Wounds of Mixed Arterial/venous Aetiology." International Wound Journal, vol. 4, no. 1, 2007, pp. 3-7.
Romanelli M, Dini V, Bertone M, et al. OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology. Int Wound J. 2007;4(1):3-7.
Romanelli, M., Dini, V., Bertone, M., Barbanera, S., & Brilli, C. (2007). OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology. International Wound Journal, 4(1), pp. 3-7.
Romanelli M, et al. OASIS Wound Matrix Versus Hyaloskin in the Treatment of Difficult-to-heal Wounds of Mixed Arterial/venous Aetiology. Int Wound J. 2007;4(1):3-7. PubMed PMID: 17425543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology. AU - Romanelli,Marco, AU - Dini,Valentina, AU - Bertone,Mariastefania, AU - Barbanera,Sabrina, AU - Brilli,Cinzia, PY - 2007/4/12/pubmed PY - 2007/6/15/medline PY - 2007/4/12/entrez SP - 3 EP - 7 JF - International wound journal JO - Int Wound J VL - 4 IS - 1 N2 - Mixed arterial/venous (A/V) ulcers are difficult to treat and slow to heal likely as a result of deficiencies in molecular and cellular elements in the wound bed. Recently, biomaterials have been developed that replace extracellular matrix (ECM) molecules and growth factors critical to the normal healing process. In this study, the effects of OASIS and Hyaloskin were evaluated to compare the effectiveness of these two ECM-based products in their ability to achieve complete wound healing of mixed A/V ulcers. After 16 weeks of treatment, patients in each group were evaluated on four criteria: complete wound healing, time to dressing change, pain and comfort. Complete wound closure was achieved in 82.6% of OASIS-treated ulcers compared with 46.2% of Hyaloskin-treated ulcers (P < 0.001). Statistically significant differences favouring the OASIS treatment group were also reported for time to dressing change (P < 0.05), pain (P < 0.05) and patient comfort (P < 0.01). Overall, OASIS was superior to Hyaloskin for the treatment of patients with mixed A/V ulcers, a population in which standard treatment options largely consist of moist wound dressings and compression therapy is typically not an option. OASIS is a useful and well-tolerated treatment for mixed A/V ulcers that has the potential to improve quality of life and reduce costs associated with standard of care. SN - 1742-4801 UR - https://www.unboundmedicine.com/medline/citation/17425543/OASIS_wound_matrix_versus_Hyaloskin_in_the_treatment_of_difficult_to_heal_wounds_of_mixed_arterial/venous_aetiology_ L2 - https://doi.org/10.1111/j.1742-481X.2007.00300.x DB - PRIME DP - Unbound Medicine ER -