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Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study.
Cancer Sci 2007; 98(4):590-7CS

Abstract

High intake of red meat has been associated with increased risk of colorectal cancer in Western countries. There has been much interest in the role of n-3 polyunsaturated fatty acids (PUFA) in colorectal cancer prevention, but epidemiological findings are limited and inconsistent. The objective of our study was to examine associations of meat, fish and fat intake with risk of colorectal cancer, paying particular attention to the subsite within the colorectum. Data were from the Fukuoka Colorectal Cancer Study, a population-based case-control study, covering 782 cases and 793 controls. Diet was assessed by interview, using newly developed personal-computer software for registering semiquantitative food frequencies. The intake of beef/pork, processed meat, total fat, saturated fat or n-6 PUFA showed no clear association with the overall or subsite-specific risk of colorectal cancer. There was an almost significant inverse association between n-3 PUFA and the risk of colorectal cancer; the covariate-adjusted odds ratio for the highest (median 3.94 g/day) versus lowest (median 1.99 g/day) quintile of energy-adjusted intake was 0.74 (95% confidence interval 0.52-1.06, trend P=0.050). The consumption of fish and fish products was similarly inversely related to the risk although the association was not statistically significant. These associations were more evident for distal colon cancer; adjusted odds ratio for the highest versus lowest quintile of n-3 PUFA intake was 0.56 (95% confidence interval 0.34-0.92, trend P=0.02). Our findings do not support the hypothesis that consumption of red meat increases colorectal cancer risk but do suggest that high intake of fish may decrease the risk, particularly of distal colon cancer.

Authors+Show Affiliations

Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ykimura@phealth.med.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17425596

Citation

Kimura, Yasumi, et al. "Meat, Fish and Fat Intake in Relation to Subsite-specific Risk of Colorectal Cancer: the Fukuoka Colorectal Cancer Study." Cancer Science, vol. 98, no. 4, 2007, pp. 590-7.
Kimura Y, Kono S, Toyomura K, et al. Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Sci. 2007;98(4):590-7.
Kimura, Y., Kono, S., Toyomura, K., Nagano, J., Mizoue, T., Moore, M. A., ... Imaizumi, N. (2007). Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Science, 98(4), pp. 590-7.
Kimura Y, et al. Meat, Fish and Fat Intake in Relation to Subsite-specific Risk of Colorectal Cancer: the Fukuoka Colorectal Cancer Study. Cancer Sci. 2007;98(4):590-7. PubMed PMID: 17425596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study. AU - Kimura,Yasumi, AU - Kono,Suminori, AU - Toyomura,Kengo, AU - Nagano,Jun, AU - Mizoue,Tetsuya, AU - Moore,Malcolm A, AU - Mibu,Ryuichi, AU - Tanaka,Masao, AU - Kakeji,Yoshihiro, AU - Maehara,Yoshihiko, AU - Okamura,Takeshi, AU - Ikejiri,Koji, AU - Futami,Kitaroh, AU - Yasunami,Yohichi, AU - Maekawa,Takafumi, AU - Takenaka,Kenji, AU - Ichimiya,Hitoshi, AU - Imaizumi,Nobutoshi, PY - 2007/4/12/pubmed PY - 2007/5/3/medline PY - 2007/4/12/entrez SP - 590 EP - 7 JF - Cancer science JO - Cancer Sci. VL - 98 IS - 4 N2 - High intake of red meat has been associated with increased risk of colorectal cancer in Western countries. There has been much interest in the role of n-3 polyunsaturated fatty acids (PUFA) in colorectal cancer prevention, but epidemiological findings are limited and inconsistent. The objective of our study was to examine associations of meat, fish and fat intake with risk of colorectal cancer, paying particular attention to the subsite within the colorectum. Data were from the Fukuoka Colorectal Cancer Study, a population-based case-control study, covering 782 cases and 793 controls. Diet was assessed by interview, using newly developed personal-computer software for registering semiquantitative food frequencies. The intake of beef/pork, processed meat, total fat, saturated fat or n-6 PUFA showed no clear association with the overall or subsite-specific risk of colorectal cancer. There was an almost significant inverse association between n-3 PUFA and the risk of colorectal cancer; the covariate-adjusted odds ratio for the highest (median 3.94 g/day) versus lowest (median 1.99 g/day) quintile of energy-adjusted intake was 0.74 (95% confidence interval 0.52-1.06, trend P=0.050). The consumption of fish and fish products was similarly inversely related to the risk although the association was not statistically significant. These associations were more evident for distal colon cancer; adjusted odds ratio for the highest versus lowest quintile of n-3 PUFA intake was 0.56 (95% confidence interval 0.34-0.92, trend P=0.02). Our findings do not support the hypothesis that consumption of red meat increases colorectal cancer risk but do suggest that high intake of fish may decrease the risk, particularly of distal colon cancer. SN - 1347-9032 UR - https://www.unboundmedicine.com/medline/citation/17425596/Meat_fish_and_fat_intake_in_relation_to_subsite_specific_risk_of_colorectal_cancer:_The_Fukuoka_Colorectal_Cancer_Study_ L2 - https://doi.org/10.1111/j.1349-7006.2007.00425.x DB - PRIME DP - Unbound Medicine ER -